DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sma-1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_741632.2 Gene:sma-1 / 179629 WormBaseID:WBGene00004855 Length:4166 Species:Caenorhabditis elegans


Alignment Length:2693 Identity:674/2693 - (25%)
Similarity:1177/2693 - (43%) Gaps:460/2693 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 ETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESYR 76
            ::.||||.|..|:..|:...::........|.::|..|.:.:||:|.||||.||:. ..|::..|
 Worm   806 QSKEDIQRRLTQMNHRWERLRVAVDALGNWLSEARHAQQYFQDANEAESWIREKMPLVKSDDLGR 870

  Fly    77 DPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQ-HFA--SESIQ-------------- 124
            |....::.:|:|...|.|:.|:.:.|..|:....::.|.. |.|  |:|:|              
 Worm   871 DEGAAESLLQRHARLEEEIRAYKSDISRLEEMQSQLANSAFHTATTSQSVQETEEVNVPQVEMSY 935

  Fly   125 ----------------------------------------------------------------- 124
                                                                             
 Worm   936 NYEGNGMRVSKGEVLALLEKSTPEWWRALKRDGTEGYVPANYCKIVPGETVTVTQTTQKTTTTLE 1000

  Fly   125 -------VRLDELHKLWE--LLLSRLAE-KGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADE 179
                   |..|..||:..  ..|.|||: :...|...:.|::|.|:|:|...|.|:.|..: |||
 Worm  1001 GNETKSSVVADRQHKISNDYRELKRLADVRRRLLSDNIKLLRFYRECDEFERWAKEIEVSL-ADE 1064

  Fly   180 FGQDLEHVEVLQRKFDEFQKDMASQ-EYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRL 243
              ...|||...:||||:.:.||.:. ..::..:|.:|:.|:.:||.:...|..|:.::|..|..|
 Worm  1065 --PSPEHVAAFRRKFDKLEADMKTNGGTQLKHINDIANDLISEGHGQSRKIEVRQHKINAMWDNL 1127

  Fly   244 KQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLA 308
            ::|...|..:|.....:..|:...:....|:..|     .:...|:...|::||    .:||||.
 Worm  1128 ERLRKQRGVRLEATERVADFDTTCESAREWMLSK-----FEQLDRNPNDVKSLQ----NLERDLK 1183

  Fly   309 ALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADF 373
            .||||::.|...|..:...|.:.:..|..|.||:......|..:|:|:....:::.....|.:..
 Worm  1184 PLEDKIAALEKLAAAVKKDHPEEAAAIERKIAELRALHADLLRRAQEKMLLAEQTQGKEMFESAL 1248

  Fly   374 RDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAA 438
            ||::.||...:.::..|....|||.||.||::|.|...:|..::...:...|.|::|||| :...
 Worm  1249 RDMIGWIEKTRKVMMEDVHPVDVAEAEELLKKHYELGEQIKDKKYEVEYCQELGRRLLER-NPRM 1312

  Fly   439 AEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLD 503
            ::::|:|..|.::.:||..|:..|..:.:|.:|||||.|::|:.|......||||..::||||::
 Worm  1313 SKVEEQLQNLVSEMASLRDLYRRRDTILKQQLDLQLFNRESERIDAATKGHEAFLEFDNLGDSVE 1377

  Fly   504 SVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKR 568
            |||.|:|:|.|.|..|.|||.:::|....|..:|..||..:..:.|||:.:||||.|::..:::|
 Worm  1378 SVENLLKRHRDLEAKLDAQEARLEAFSRTADDMIKAQHADSAYIEQRRRDVLARREAVRRAAAQR 1442

  Fly   569 RQLLEDSNRYQQFERDCDETKGWISEKLK--FATDDSYLDPTNLNGKMQKHQNFEHELNANKSRI 631
            ::.||.|..||:..|:.||..||:.||.|  .:.|||.|.|:.:..::.||:.||.|:.||:.||
 Worm  1443 KKQLEASLEYQEMRREADEVVGWMYEKAKLVMSGDDSALAPSAIPHRLLKHEAFEAEIIANEPRI 1507

  Fly   632 EDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELW 696
            :.|.:.|..|:.|:||.:..:...::::...|..|.:....||.:|.:|..|:..:|.:||....
 Worm  1508 QQINSEGDGLVSKKHYESPNVEKIVRQVNAQWGDLKKQVWNKGLRLRQAADQKGLDRILEDAHAK 1572

  Fly   697 LSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNK 761
            |.|::..|.|:|.|.||.||::|.:|||:||.::..:.:::..|:....|....||:|||.|.:.
 Worm  1573 LDEMQTALNSKDQGLDLRSVKDLLQKHAVLEQEMGLYGNKLSDIENRGKKMAVDGHYDADRIHST 1637

  Fly   762 EGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLI 826
            .|.|..||||:..|...||..|.:|....||..|::.|..||.||:|||:|.:.||.|....|::
 Worm  1638 VGQLLQRYAAMKGPAQRRKGDLDESRLWHQLVFDVDCELQWIAEKKPIASSQDCGRTLTEALNMV 1702

  Fly   827 KKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDD 891
            ||.:.:.||:|.|..::..|:.....::|....||..|:.:...|:..|:.||:....|:..:|.
 Worm  1703 KKQEQLEAEVNQHGGQIDKVLLQAGELIKRHHSASSQIKAKSSELETAWSELKKLLRLRRAVVDW 1767

  Fly   892 SLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQA 956
            .::..||..||.|.||||.||.......|||.|||::..||.||.||..|:..:...::.|:   
 Worm  1768 GVKEQQYLFDAAEVESWMNEKRNALASEDYGNDEDAARKLLSKHRALCEDMTTYRQWLEKLE--- 1829

  Fly   957 KNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPA 1021
                           .:||                      .|:.||.                 
 Worm  1830 ---------------VKCV----------------------ELVESNR----------------- 1840

  Fly  1022 AYIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLA 1086
            .::::..                 |||:::..::|.|..||.:|:|.|.:.|..|..:||:|||.
 Worm  1841 PHVERFQ-----------------KRQDELVREFDALSKLAEDRRNALEDAVCLYEYMRESADLG 1888

  Fly  1087 QWIRDKEN-HAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAAL 1150
            |.|  :|| ...:::...||.|.::.||.|||:|...:|....|..:. |.|...........|.
 Worm  1889 QSI--EENLRVAMSEEFAEDYEHLKELQSKFDEFKQKVKNGSERFTSC-ETAANAILRRNPPFAR 1950

  Fly  1151 KIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEK-ANALNNDDLGKDLR 1214
            .:..:.:.|...||.|......:.|:|..|.|:.|||||:||.:.|:|:| ||...  |||:|::
 Worm  1951 DVVKKQEALRTAWNTLCEYIEARDSKLAVAEELHRFHRDVDEFEQWMADKMANMPR--DLGRDVK 2013

  Fly  1215 SVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTA 1278
            .|.:|.:.||.:::::...:.::.:|.|.|.||.:::| ..|||...:|:.:.:.|:::...:..
 Worm  2014 HVHSLWQHHEALDKEIHNSQPRLAKLVEEAERLKKTYPGGNAEQIGGRQQTLEQEWEELKNATDD 2078

  Fly  1279 RKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGIS 1343
            ||:.|..::||..|....||||||.:..:|.:.||...||:..||.|...|...           
 Worm  2079 RKDMLRAAFDLHTFNGKVRDLLAWTDLTISDIQSDLHINDLQQAEWLQTEHSRL----------- 2132

  Fly  1344 SAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKARE 1408
                               .|  |:|||...|......|.:::.|.||||.|||.|...|..|.|
 Worm  2133 -------------------SH--EMDAREPEFARLVNDGEKMITAQHYASEEIKNKTHLLKSALE 2176

  Fly  1409 DLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKA 1473
            .|...|..|...|.|.:....:.|:.:...:.:.::...|.:.....:..:||:..|:.:.|:||
 Worm  2177 RLRSEWALRNGFLSQAVQWHAFQREAKQIIASIGSKRTTLRSLAVGGSVADVESQTKRLDTFEKA 2241

  Fly  1474 INGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSR 1538
            ::..:::.|.|...|::|:...|..|..:...:..|.|..:.|::.:..:.:.|.|...|..|..
 Worm  2242 LSTLDERTATLDHTANELMKARHMESKNISMWQSNVHEELKLLRQDIEARHAMLKDAFALASFDS 2306

  Fly  1539 DADEIENWIAEKL-------QLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNL 1596
            |..:||.||.||.       .|::|....|..  ..:.|.|||.|||:.||...:..:|..|..|
 Worm  2307 DVAQIEAWIDEKTNGVRKAQDLSSESISIDEK--MKRLQTHQALEAEVTANKPVVDQILQRGNQL 2369

  Fly  1597 IDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLL 1661
            .:..:    ...:..|..:::.:|..|:....::||.|:||.....:...|:::..|:.|.|.|:
 Worm  2370 KNLHR----NPKIANRCDELSYKWNQLSGACADQSLALEEARDLLRFKQLVENVLAWINEKEVLV 2430

  Fly  1662 TTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERY 1726
            :|.|.|||:...:.|:::.....:|.:..|..:.::|...:.||:.|:.....:|:::|.:||::
 Worm  2431 STADMGKDMEHCRLLLERLDGTRSDSIVDEQTLDEINRLGEKLVKQGRSSRDQVQKEQQHLNEKW 2495

  Fly  1727 ERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEA 1791
            ..:....||.:..|..|:.:|.|.||:.|.:..|.||...:.|||||:|...|:.|.:|...||.
 Worm  2496 RLLLGQLAHYRTELLAAMEVHTFNRDVEDTDERIHEKVAAMKSDDYGKDFASVELLVRKQSALER 2560

  Fly  1792 ELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQ----RLKALNQAWAELKNLAATRGQKLDESLTY 1852
            ::.:....:.|..:..:|:::..    |.:.:    .||.|.::|.:|...|..|.:||:.|...
 Worm  2561 DMSAIHQKLIAHDKDAQKILEKR----PPLRETVLDSLKKLEESWEQLSKAAELRNEKLNRSFKL 2621

  Fly  1853 QQFLAQVEEEEAWITE-KQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSEL 1916
            .::|..|::.|.|..: :.::.|.:...||..| :.:|::|...:.:.....:...|:.::|..|
 Worm  2622 YKYLDDVKKVEQWANQVRNKMTSHQTPKDSNGA-RKILEQHHERKAEIDGRSEELRLLHEEGQAL 2685

  Fly  1917 VEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFM-WKADVV--ESWIDDKENY 1978
            .:.:..|...:.:..::::.....|.......||.|   ...|::| |..:.|  |.|:.|||..
 Worm  2686 NQEQPEHKAEVQRAHKRVQNSEHQLRQTWESEKGTL---QKLLEWMLWCDEAVQCEQWLSDKETQ 2747

  Fly  1979 VRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQ------EGIHNITALKDQLINASHAQSPAILKR 2037
            |...|.|.....|:.|:       .|.:|||:      |.|..:|...|.|::..:.....|:.|
 Worm  2748 VARGELGDTTDAVEMLI-------KGHSAFEETVRKQSEKIDALTKNADALVSGGNNYRADIVTR 2805

  Fly  2038 HGDVIARWQKLRDASNTRKDRL---LAMQEQFRQIEELYLTFA---------------------K 2078
            ..:|.||...|..:...|...|   ....|..||..||.:...                     :
 Worm  2806 SEEVTARHALLLKSMEKRGHMLEDSKKYHEFIRQCGELIIWITAKLQLAYDESFLDHTNLRSKLQ 2870

  Fly  2079 KASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAH---AQFQASLSSAEADFKAL----AALDQK 2136
            |..||:|.....|:.|:...|    :..:.:.|.|   .|.:|.|....:.:..|    |...|:
 Worm  2871 KHMAFDSELVENEKRLSTVER----QGEQLVTDNHFMSEQVKAQLVELRSGWDELRTKSALKTQR 2931

  Fly  2137 IKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELA--------------------------- 2174
            ::..         |.:.:|:....:::|.:::.:|||:                           
 Worm  2932 LREA---------FELHSLQRKVEDIEKWLDKVEGELSSDDHGRDILSTELLIKKLDTLQTEIAG 2987

  Fly  2175 ---------------------------KEAKRQE-------ENDKLRKEFAKHANLFHQWL---- 2201
                                       |:|::.|       |..::|:|....|..|.||:    
 Worm  2988 RSDAVVEMMKKARELRVQGSAAADDCLKQAEQVEARYSGLDEPVQIRRENLVDAQAFFQWVKAAE 3052

  Fly  2202 -----TETRYYMLGYNRQGTSMMEG------SGSLEQQLEALRVKATEVRARRVDL--------- 2246
                 ...|..:......|.|:...      ..:||::|:..:....:...|..|:         
 Worm  3053 EDLEWLSDRMMLASSGESGDSLQSALSLQKKHATLEKELDTRQSAMNDTEQRGKDMIRQRHFAST 3117

  Fly  2247 ---KKIEELGA--------------LLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQ 2294
               |.::.|.:              ||:|.:.....|||.:.   |:||.: :|:.:.|     .
 Worm  3118 HIQKILDRLSSAMLTLKESCGLRRDLLQEAIDAHEYYTEETE---AEQWLR-EQMPLAM-----S 3173

  Fly  2295 QIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAIL 2359
            |...|:.:| :|..|:..:::      ||..:|                           |:..:
 Worm  3174 QEMGRDQAG-AESHLRRLTVL------DKEVEL---------------------------FKNEI 3204

  Fly  2360 DVVDPNRDGYVSLQEYIAFMISKETENVQS-YEEI--ENAFRAITAADRPYVTKEELYCNLTKDM 2421
            |.:....||.::.:.:.|..|:.:...::: :.::  |.|.|.....|   .:|...:.....|:
 Worm  3205 DRLKKRADGLLAREHHDAMSIAAKQRKLEALFGDLCRECARRRTQIVD---ASKYHKFVRQADDL 3266

  Fly  2422 ADYCVQRMKPFSEPRSGQPIKDALDYID 2449
            :|:..::.:..|....||.::|....|:
 Worm  3267 SDWLREKERSASAEDYGQDLEDCQQIIE 3294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 5/51 (10%)
SPEC 1074..1287 CDD:238103 66/215 (31%)
SPEC 1182..1425 CDD:238103 77/244 (32%)
SPEC 1426..1638 CDD:238103 50/218 (23%)
SPEC 1533..1744 CDD:238103 56/217 (26%)
SPEC 1646..1850 CDD:238103 56/207 (27%)
SPEC 1852..2062 CDD:238103 49/222 (22%)
SPEC 1958..2176 CDD:238103 57/311 (18%)
SPEC 2072..2296 CDD:238103 53/353 (15%)
EFh 2311..2379 CDD:238008 8/67 (12%)
EFhand_Ca_insen 2386..2456 CDD:400872 12/67 (18%)
SPEC 48..258 CDD:238103 68/303 (22%)
SPEC 154..364 CDD:238103 58/210 (28%)
SPEC 261..470 CDD:238103 55/208 (26%)
SPEC 471..680 CDD:238103 80/210 (38%)
SPEC 682..893 CDD:238103 72/210 (34%)
Spectrin 893..>961 CDD:395348 25/67 (37%)
sma-1NP_741632.2 CH 155..258 CDD:237981
CH 276..379 CDD:237981
SPEC 524..735 CDD:238103
SPEC 737..916 CDD:238103 32/109 (29%)
SH3 928..979 CDD:214620 0/50 (0%)
SPEC 1039..1237 CDD:238103 58/209 (28%)
SPEC 1242..1450 CDD:238103 74/208 (36%)
SPEC 1453..1553 CDD:197544 33/99 (33%)
SPEC 1562..1762 CDD:238103 69/199 (35%)
SPEC 1664..1874 CDD:238103 73/283 (26%)
SPEC 1770..1980 CDD:238103 71/286 (25%)
SCP-1 1967..2724 CDD:114219 206/804 (26%)
SPEC 1982..2192 CDD:238103 76/243 (31%)
SPEC 2194..2407 CDD:238103 50/218 (23%)
SPEC 2408..2618 CDD:238103 56/213 (26%)
SPEC 2620..2830 CDD:238103 49/220 (22%)
SPEC 2832..3041 CDD:238103 32/221 (14%)
SPEC 3044..3253 CDD:238103 42/254 (17%)
SPEC 3255..3466 CDD:238103 8/40 (20%)
SPEC 3361..3574 CDD:238103
SPEC 3472..3689 CDD:238103
PH_beta_spectrin 3780..3883 CDD:269975
PH 3780..3881 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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