DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and unc-70

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001256073.1 Gene:unc-70 / 179077 WormBaseID:WBGene00006803 Length:2326 Species:Caenorhabditis elegans


Alignment Length:1703 Identity:479/1703 - (28%)
Similarity:812/1703 - (47%) Gaps:244/1703 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 EDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQA-ASEESYRDPT 79
            ::|..|..::....|..|..:..::|:|.....:..|..|||:::.::::.|:. :||:..:|..
 Worm   772 DNIPPRLAEIRDYINKLKELSASRKERLAGGVEYYQFFTDADDVDRYLYDTLRVMSSEDVGKDEG 836

  Fly    80 NLQAKIQKH-------QAFEAEVSA-HSNAIVSLDNTGQEMINQQHFASESIQVRLD-------E 129
            .:|..::||       |.|:..:.. |:.|         |.:.|:......|:.|||       |
 Worm   837 TVQLLLKKHDDVHDELQNFDQHIKVLHAKA---------ESLPQEAREHPDIRQRLDTTLKQKAE 892

  Fly   130 LHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKF 194
            |..|.:|...||.:       ||.|.:.....:.|..||.:|...:.....|:|:|.||:::.:|
 Worm   893 LENLSQLRKQRLID-------ALSLYKLYSDADSVESWIDEKGKLLATLVPGRDIEEVEIMKHRF 950

  Fly   195 DEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHE 259
            |..::||.:||.:||.||.||.:|:...||..|.|..|:.:||..|.:|:.:...::.:|..||.
 Worm   951 DTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQNKLNARWAQLRDMVDQKRNELERAHR 1015

  Fly   260 IQRFNRDADETVAWIAEKDVVL-SSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQR 323
            ::.|..|..|||.||.:|..|| .||....||:.|..|||:...:||||.|::.|:.:|..||..
 Worm  1016 LETFRIDCQETVTWIEDKTRVLEDSDALTNDLSGVMKLQRRLSMMERDLGAIQAKLDSLHKEADD 1080

  Fly   324 LCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIIS 388
            :.......:..||:....|...|..|..|.||.:.||||:..|.|||.|.....:|:...:..::
 Worm  1081 IERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLDEAGDLQRFLRDLDHFQAWLTATQRQVA 1145

  Fly   389 ADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLERE---HYAAAEIQEKLAALEN 450
            ::|..:.:|.||.||.:|...:.|||...:.:|.....|.::.:.:   .|..  ::::||.|:.
 Worm  1146 SEEEPQSLAEAEQLLNQHAAIREEIDGYAEDYKKMRAMGDRVTQDQTDPQYMF--LRQRLAGLQE 1208

  Fly   451 DKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDF 515
            ....|..:|::|:.|..|.::||:|.||.:||:..:::||.:||.:|:..||:..|..:|:|:||
 Worm  1209 GWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVMLSQQENYLAKDDIPQSLEQAENQLKRHQDF 1273

  Fly   516 EKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQ 580
            ..::.|.:|||:|:.:|..:|....|||||.:.::.:.:..||.|.:||:.:..:.|:|:...||
 Worm  1274 ITTMDANDEKIRAVGMFGDQLCQDGHYAADKIHKKARNIDERRGANREKAQEVLKKLKDALSLQQ 1338

  Fly   581 FERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQ 645
            |..||||.:.||.||:..|.|::|.|...:..|..:||.|:.||.|||.|::.:.:....|.:.:
 Worm  1339 FLSDCDELREWIEEKMIRAQDETYRDAKTITSKFVRHQAFQSELAANKERLDQLKHAAINLGDDK 1403

  Fly   646 HYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHG 710
            ......|:.:::|:...|:.|.:.:::||.||.:|.:||.:.::|.|::.|.:::|.::..||..
 Worm  1404 PEYHGTIDPQIEELATQWDELEKTTEEKGQKLFDANRQQLYVQSIADMKEWATQLENEMTREDQP 1468

  Fly   711 KDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAP 775
            .|||:|....:|..|:|.:::.....|:.:.....:..|....:.:||:.....:..:...|.||
 Worm  1469 GDLTTVNVAMQKQHLIETEMIKKAQHIDQLMEMEPQLEELHPDELENIKAHRLAVQEQLQRLQAP 1533

  Fly   776 MGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHE 840
            :.:|::.|.......|..||::||..||.|:..:|.:.|.|..|.....|.|..|.:..||:|||
 Worm  1534 LDDRRKALERKKAAFQFGRDVDDEKLWISERLVLAKAQNLGESLPDCHRLQKNLQLLSNEIDNHE 1598

  Fly   841 ARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEA 905
            ..:..:.::|:.::.:.........::::.|:..|..|||....||.||.:|.:|||:..|..||
 Worm  1599 PWINQICNNGQELIDEGHANGPAFEKKIQELRSAWQELKEAVKDRKGDLGESEKAHQFLYDCGEA 1663

  Fly   906 ESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDIT 970
            |:||.|:|......:.||||.|::..:||||.|.||::.|.:||:||..:|....::::|:.:  
 Worm  1664 EAWMSEQELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADTIRALATKAHKFVEEKSPLTE-- 1726

  Fly   971 GKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQ 1035
                                                                             
 Worm  1727 ----------------------------------------------------------------- 1726

  Fly  1036 QNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIAD 1100
                   .|..||.||...|..|..|::||:.:|.||::.|.|.||..||.|||.|||       
 Worm  1727 -------QIQVRQAQIEKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQWIADKE------- 1777

  Fly  1101 VV------GEDLEEVEVLQKKFDDF-NDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQD 1158
            ||      |:|.|.|::||::|..| .|.......|:||.|:....|...|.|:|. .|......
 Worm  1778 VVAGSQENGQDYEHVQMLQERFQQFARDTENIGSERVANANDGCDTLIGHGHTDAP-TIALWKDS 1841

  Fly  1159 LNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKH 1223
            |||.|.||..|...:|..|.::..:.:|:.|..:....|.||.:|: .||||:|..||..|.|||
 Worm  1842 LNEAWENLLELMDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAM-PDDLGRDSSSVGALSRKH 1905

  Fly  1224 EGVERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSY 1287
            :...:|:||:.:::.|::..|..|...:. |.|....:::.|:.:.|..:.....||..:|:|:.
 Worm  1906 QNYLKDIAAIGEQVAQIERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDARTSRLMDTS 1970

  Fly  1288 DLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAAST 1352
            ||.:|::..||||.|::.:...:.|.|...||:|.|.|:..||:.:|                  
 Worm  1971 DLFKFMNMVRDLLLWMDEVKREMNSQERPKDVSGVELLMNNHQSLKA------------------ 2017

  Fly  1353 SSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTER 1417
                          |||||...|.|....|.:||...||||.||::|:..|...|.::.:.|.:|
 Worm  2018 --------------EIDAREENFNACISLGRDLLNRKHYASSEIEKKLIKLTTERAEMMRRWEDR 2068

  Fly  1418 RLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVE---ALIKKHEDFDKAINGHEQ 1479
            ...|:..|::..:.||..:||||:.|:|.:|.:.:   .|.|:|   .||||||.|:|:....|:
 Worm  2069 WEYLQLILEVYQFARDAAVAESWLFAQEPYLISKE---YGRNLEETIKLIKKHEAFEKSAFAQEE 2130

  Fly  1480 KIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHL---------------------KEG---- 1519
            :..||:.:....:.:..:......::|...     |:                     |:|    
 Worm  2131 RFLALEKLTTFELKETQHREEETAKRRGPA-----HIGSPSRSTPAAETSFGAQDDGAKQGEAFE 2190

  Fly  1520 --LIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEES----YKDPANIQSKHQKHQAF--- 1575
              ||.|       .|.:...|.|.. .:|  |||.....::    ||||     ||:.....   
 Worm  2191 GTLIRK-------HTYESLDRKAAN-RSW--EKLYAVLRQNELSFYKDP-----KHRDESVHGEP 2240

  Fly  1576 -------EAELAANADRIQSVLAM----GGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTE 1629
                   ...:|::..:.::||::    |...:  .|| |||:.:|:.||::         :...
 Worm  2241 PMALPGCSVNVASDYQKKKNVLSLRLPIGAEYL--FQC-GSEEDMQRWLTEL---------QVAT 2293

  Fly  1630 KSLKLKEANKQRT 1642
            ...:|:||::.:|
 Worm  2294 GQAQLEEASRSQT 2306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 72/220 (33%)
SPEC 1182..1425 CDD:238103 71/243 (29%)
SPEC 1426..1638 CDD:238103 57/259 (22%)
SPEC 1533..1744 CDD:238103 28/128 (22%)
SPEC 1646..1850 CDD:238103
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 62/225 (28%)
SPEC 154..364 CDD:238103 74/210 (35%)
SPEC 261..470 CDD:238103 66/212 (31%)
SPEC 471..680 CDD:238103 72/208 (35%)
SPEC 682..893 CDD:238103 54/210 (26%)
Spectrin 893..>961 CDD:395348 29/67 (43%)
unc-70NP_001256073.1 CH 110..208 CDD:278723
CH 229..333 CDD:237981
SPEC 368..580 CDD:238103
SPEC 481..695 CDD:238103
SPEC 698..908 CDD:238103 33/151 (22%)
SPEC 804..1014 CDD:238103 62/225 (28%)
SPEC 910..1120 CDD:238103 73/209 (35%)
SPEC 1122..1334 CDD:238103 65/213 (31%)
SPEC 1230..1439 CDD:238103 72/208 (35%)
SPEC 1440..1650 CDD:238103 54/209 (26%)
SPEC 1652..1864 CDD:238103 84/293 (29%)
SPEC 1865..2073 CDD:238103 70/240 (29%)
SPEC 2079..>2157 CDD:197544 23/80 (29%)
PH_beta_spectrin 2189..2290 CDD:269975 28/127 (22%)
PH 2190..2290 CDD:278594 28/126 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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