DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and C50C3.2

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_498787.3 Gene:C50C3.2 / 176154 WormBaseID:WBGene00016800 Length:2236 Species:Caenorhabditis elegans


Alignment Length:2611 Identity:530/2611 - (20%)
Similarity:1055/2611 - (40%) Gaps:555/2611 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAA--------S 71
            |.:|:.:|.|||.::.||:::...||..:..||:.|.:.|.|.|.:..|...::::        |
 Worm    11 VREIEGQRVQVLQKFADFELKAINKRSSIIQSRQLQVYLRSAAEFKQVIESLIESSEAVVTSQCS 75

  Fly    72 EESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWEL 136
            |.|.|.    |..|.:   .:.|.....|.:..|:|....::.:.|:||:.||...:.:...||.
 Worm    76 ESSIRG----QKVIGR---LQQEADGKHNNLPMLENEAARLLKEGHYASDEIQKTFNNVLSRWEY 133

  Fly   137 LLSRLAEKGLKLQQALVLVQFLRQCEEVMFWI-KDKETFVTADEFGQDLEHVEVLQRKFDEFQK- 199
            ||..||.|..:|::.:..::|..:|:.::.|| |.||    :||.|:::         |||.:| 
 Worm   134 LLKLLALKWRQLEKEIESIEFKNKCDSIVDWILKIKE----SDESGKEI---------FDEIRKC 185

  Fly   200 DMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFN 264
            .|...|...| ..|:.|....|        |...|:::|.|...::......:||......|:|.
 Worm   186 SMVWNEISAT-FQQMLDPTATD--------TSNYEKVHETWSNFQEYIDSLHKKLSENERFQKFV 241

  Fly   265 RDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTL-----GAEAQRL 324
            .:|::.:.|:.:|:..: .:.|.:  ...:.:.:..:.||.::.::|.::..|     |.|...|
 Worm   242 DNAEDLIKWMDDKEKEI-CEKYSK--MDFEVMMKYRKTVEIEMKSVEQRIKDLKEQFVGMENDNL 303

  Fly   325 CSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSW----INGMKA 385
            .:| .|..:.:.|    :...::|.....::.|..::.|....:.:.:..::..|    |..:|.
 Worm   304 RNI-PDPKNHVID----VEQRFESFQAFVQKWKTDIENSADADKLMKEAENICCWSSEKIEDLKI 363

  Fly   386 IISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREH--YAAAEIQEKLAAL 448
            :.::     |....:.::...:.:..:.::.::.......|.|:||.:::  ....|::......
 Worm   364 MATS-----DTPDCDEIIMWIETNNFDFNSWDNVVVQFLASSQELLNKQNNGNVKQEVERTTELY 423

  Fly   449 ENDKSSLLS---LWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLAN----------EDLGD 500
            |..|.::.:   ..|||    .|.::::.....|.|....:|   :||.|          ||:..
 Worm   424 ELAKRTMKTCNEFLEDR----IQTINMEKLIFQTHQKAVILA---SFLQNHEESPEDMNAEDIEK 481

  Fly   501 SLDSVE-------ALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLL--- 555
            .:..::       :::::.|:.|..|..:.|::..|.::|:|.:       :|:.:.:::|.   
 Worm   482 EIRVIDGITVRCTSVVEQIENIEDELRQKPEQLNQLSVYASKQV-------NDLNEMKEVLKTTV 539

  Fly   556 -ARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQN 619
             :|:|.||       :||:    ...|..:|.||:.        .||....:..:...|::..|.
 Worm   540 NSRKAILQ-------RLLD----VTYFLDNCCETRK--------HTDTMLSNVKSSRVKLEIVQP 585

  Fly   620 FEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQ 684
            .:.:|::.|..:.|:      :::.|     |.|...:|:...:|.|.:...:.|.:.::...::
 Worm   586 IKDQLDSLKVEMVDM------MLDDQ-----QKNMANEELRKTYENLKKIEMEVGRQASQKEARK 639

  Fly   685 QFNRT---IEDIELWLSEIEGQLLSEDHGKDLTS-VQNLQKKHALLEADVMAHQDRIESIKVAAN 745
            ..:||   :..::.|   |:...:.:|  .|:.| ..||::        ...|...:.||..:..
 Worm   640 AADRTEAFVGRVQNW---IDNNQIQDD--TDIVSETVNLRR--------TTTHYQHLLSICASYK 691

  Fly   746 KFIES-----GHFDADN--------IRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLE 797
            |.|:|     .:...||        |:|...|...:       :.::.......|.:.:...:|.
 Worm   692 KSIDSKLEELANVYTDNDPRCLLEGIQNSVENFEVK-------IHQKVDDTKKLLHITENMNELN 749

  Fly   798 DEAAWIREK------EPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKD 856
            .:..|||.|      ||:..|      |:..|.:.::|.....||.|...::..||..... .||
 Worm   750 SQNEWIRAKIKSLSAEPLWDS------LLIAQKMRRRHDNDFEEIANRRKQITEVIQKSAT-TKD 807

  Fly   857 QPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDY 921
            ||.        |..:::.|:.:|:...:|...|:..::.::|..:::....|:|||...|...:.
 Worm   808 QPI--------LLEIEQNWDRMKDLFDERGGVLERIIKLYEYDEESSTTSEWLREKMICADTIEP 864

  Fly   922 GKDEDSSEALLKKHEALVSDLEAFGNTI---QALQEQAKNCRQQETPVVDITGKECVVALYDYTE 983
            .:||..:|.::||.|||..::|.:...|   .||.|.|                           
 Worm   865 KEDESFNEVMVKKLEALTEEVENYKPRIVETHALLEDA--------------------------- 902

  Fly   984 KSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIAKRQ 1048
                           |:..|.||                         |.|||.:.....:|::|
 Worm   903 ---------------LVTPNTKD-------------------------STSQQTMKLKAVLARKQ 927

  Fly  1049 NQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQ 1113
            .:|.|.|..|..|...:...|...::...:..:.||:.|||..::|  |:...:..|.:|   |.
 Worm   928 GEIESDYKALKKLVERKLKTLKAILQDADISHQIADIEQWIEVEQN--QLNRYLASDSDE---LP 987

  Fly  1114 KKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLG 1178
            .|.||...:::.   |.:|:.:|...:..          |.|||.:::.:..|...:.|......
 Worm   988 TKLDDVMTNIQR---RRSNLTDIKCNVVG----------QVQMQKIDDAFGMLDVFSFEVHRIRQ 1039

  Fly  1179 SAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSV---QTLQRKHE-------GVERDLAAL 1233
            .|..::.|.:...:|:|.|         |.:...|..:   |:..||.:       .:..||..|
 Worm  1040 KACRLEIFKKLESQTEDVI---------DAIQMKLEEINVSQSTSRKRQVAGDDLSNLAGDLETL 1095

  Fly  1234 RDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRD 1298
            |.::.:..:.:..:..::.|.|.|.|..::.:.:.|.. ::|:....:|.::..   :.||    
 Worm  1096 RRRVVEALDRSKEVRAANADLAPQVYDTEERLEKQWTD-VSKAYENHKKRMERC---KILS---- 1152

  Fly  1299 LLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLG-ISSAPGAAASTSSIASPSGDE 1362
                           ||.|::...|..|:..   ..|:...:| |....|......||.:...:.
 Worm  1153 ---------------ELDNEMINMEQWIDTF---NEEVTVVIGSIHDGLGVQVGLESIDTWREEL 1199

  Fly  1363 EHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNL-- 1425
            .||  :|...|...:....||.:.:                    :|....|.||...:|.||  
 Worm  1200 SHR--VDQLGGVKNSLSSVGNAITE--------------------QDKMDPWLERVSNIENNLVK 1242

  Fly  1426 ----------------DLQLYMRDCELAESWMSAREAFLNADD---DANAGGNVEALIKKHEDFD 1471
                            |:....||||...||.|.:...|..:.   ||      :.|:::..:.:
 Worm  1243 ARETIDTKQDDLCRFADILGAERDCERLYSWASGKRHQLETEATMCDA------KTLVRRMNEVE 1301

  Fly  1472 KAINGHEQKIAALQTVADQLIA---QNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTL 1533
            |.:.....::..|:...|.|.|   .:.:.:..::.|.:.:...|.||:|.|..:...|.|..:.
 Worm  1302 KMMMSRIGEVDQLRDFLDNLKASKTSDTFQTTELENKFELLDVEWNHLEEELRRREVDLNDSMSQ 1366

  Fly  1534 QQFSRDADEIENWIAEK---LQLATEESYK-DPANIQSKHQKHQAFEAELAANADRIQSVLAMGG 1594
            .......|.|..||.|:   |:...|.|.| .|.:|:...::|.    |||::.:...::..   
 Worm  1367 ILIDEQFDTIRQWIKERTEALEADVEVSNKTKPDDIERMQKRHD----ELASDINDYHTIYE--- 1424

  Fly  1595 NLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTT--EKSLKLKEANKQRTYIAAVKDLDFWLGEV 1657
            :.::..|.  .|:.||    .|...|..|...:|  :||| .:|..|.|.: ..:..:..||.:.
 Worm  1425 DFLNNGQV--EEEKVQ----VIRHLWSSLIESSTTRQKSL-AQECQKSRLF-ELLDGMSIWLIDA 1481

  Fly  1658 ESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQA---DSLVESGQFDTAGIQEKR 1719
            |:         |:.|..|.:..:..|:|:..:.  .:..:..||   |.::...|.|        
 Worm  1482 ET---------DVHSTTNFIGLYNSVDAEKASR--LLVSLGEQAGEKDDILIRIQCD-------- 1527

  Fly  1720 QSINERYERICNLAAHRQARL---NEAL----TLHQFFRDIADEESWIKEKKLLVGSDDYGRDLT 1777
            :|::...|::.|..:..|..:   ||.|    ::.:....|.||..|.||..::..|.:.|.|::
 Worm  1528 ESVDVIVEKLRNGISQLQMLIKANNEDLDVWKSMQKVVTAIDDEICWFKEINVIFSSTNVGNDVS 1592

  Fly  1778 GVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAEL------- 1835
            ....||:||:||:.|....|..:..|.....:|  ||:...|.:|.:...:::..|||       
 Worm  1593 SNDVLKRKHQRLQLETQRREQKVAKVVYLTTEL--VSSHRRPSLEYKFVEIDEKVAELTELLESN 1655

  Fly  1836 KNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFT 1900
            :.:|..|..:|::...|...:.::.|:|..:   .|:|.::. |.....:..:.:|....|| ..
 Worm  1656 RQIAEIRTNRLEKWTEYFVTMNEIREKEQLL---DQILDLKT-GLPETVLADVERKLQVLET-VG 1715

  Fly  1901 AHKDRCSLICDQGS--ELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMW 1963
            .|.|..::..:|.|  |::..|     .......|||.|...::....:....:.::..:.:|:.
 Worm  1716 DHMDTLTIKAEQMSDDEVIRTK-----VAVTAIDQLRKKWLKMNEELKKMHQKIKESIEFTKFVS 1775

  Fly  1964 KADVVESWIDDKE----NYVRSDEFGRDL--STVQTLLTKQETFDAGLNAFEQ-----EGIHNIT 2017
            ..|.....|.::|    |.||..:...:.  :...:.:|..||:..  :.||:     ..:.|.|
 Worm  1776 TCDTGIQCIREQEEKIGNLVRHQKPASNFENTAYHSTMTFVETYTK--DTFEKLKVVCRKLQNST 1838

  Fly  2018 ------ALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFR-QIEELYLT 2075
                  :|..:.:||        ||:..|::|              ..:|:.::|: :::.:...
 Worm  1839 DAEKKLSLVSERLNA--------LKKQLDLLA--------------EKIAVDDKFKLKVQNIQDE 1881

  Fly  2076 FAKKASAFNSWFENAEEDLTDPV-----------RCNSIEEIRALRDAHAQFQASLSSAEADFKA 2129
            :::.|....:|.|.||||::|.|           |...:|.:..||:..:.....|...|.:   
 Worm  1882 YSRTACELGNWLEQAEEDVSDVVWFQTKDSSEDCRETLLEILGTLRNEKSDLLGELELLEVE--- 1943

  Fly  2130 LAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQKIIEER----DGELAKEAKRQEENDKLRKEF 2190
            ||.|.:.:|:|       ||.:.:.|......|.:.|.:|    |||::    |..:|:|:.::.
 Worm  1944 LAELKEDVKTF-------TWHSFKTLATRMERLDQTISDRIRIADGEIS----RHSDNEKICEQA 1997

  Fly  2191 AKHANLFHQWLTETR-----YYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIE 2250
            |.....:|..:.:.:     .|.|              .||.|.::|.....:|:.|.: ::.:|
 Worm  1998 ACTLKTYHNVIVDVKKELEILYSL--------------KLEDQKKSLINLIDKVQKRGM-IQDLE 2047

  Fly  2251 ELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMM 2315
            :..:|:|...|.:|:::..:..|:..:..|..:|...|..::||.|..|||:||:|..|.||.:.
 Worm  2048 KWRSLMESRYIFNNKFSSATPHGVLVEMCQCLELMSSMLRSVEQSIADRNHNGVTEKQLHEFELA 2112

  Fly  2316 FKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMI 2380
            |.:||::::|.|:::.|:.||::.||:.      ..:...:..:.::||:..|::...:|:.:|:
 Worm  2113 FDYFDRERNGWLDYKHFELCLKSQGYNF------SAENTLKETMTLLDPSTTGHIQKHDYVRYMV 2171

  Fly  2381 SKETENV-QSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDA 2444
            ..||.|: ..:..||:|.:.:.|        .::..::.:..|::.:.::...:|..|.|..   
 Worm  2172 KHETTNILDDHSAIEDALKNLDA--------RKISDSMPRKEAEFFMSKIAKHAETSSDQVY--- 2225

  Fly  2445 LDYIDFTRTLF 2455
            |:|.||..:.:
 Worm  2226 LEYKDFVNSFY 2236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 4/51 (8%)
SPEC 1074..1287 CDD:238103 43/222 (19%)
SPEC 1182..1425 CDD:238103 44/253 (17%)
SPEC 1426..1638 CDD:238103 52/223 (23%)
SPEC 1533..1744 CDD:238103 48/222 (22%)
SPEC 1646..1850 CDD:238103 49/220 (22%)
SPEC 1852..2062 CDD:238103 40/228 (18%)
SPEC 1958..2176 CDD:238103 52/250 (21%)
SPEC 2072..2296 CDD:238103 53/243 (22%)
EFh 2311..2379 CDD:238008 16/67 (24%)
EFhand_Ca_insen 2386..2456 CDD:400872 13/71 (18%)
SPEC 48..258 CDD:238103 54/219 (25%)
SPEC 154..364 CDD:238103 44/216 (20%)
SPEC 261..470 CDD:238103 34/222 (15%)
SPEC 471..680 CDD:238103 41/229 (18%)
SPEC 682..893 CDD:238103 46/233 (20%)
Spectrin 893..>961 CDD:395348 20/70 (29%)
C50C3.2NP_498787.3 SPEC 44..>165 CDD:295325 30/127 (24%)
SPEC 238..335 CDD:197544 18/104 (17%)
SbcC 529..1170 CDD:223496 157/825 (19%)
SPEC 837..1069 CDD:238103 65/325 (20%)
SPEC 1265..1461 CDD:238103 50/215 (23%)
SPEC 1562..1768 CDD:238103 48/217 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0040
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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