Protein Alignment alpha-Spec and Actn2

DIOPT Version :9

• Sequence 1: NP_001261286.1
• Gene: alpha-Spec / 38231
• FlyBaseID: FBgn0250789
• Length: 2457
• Species: Drosophila melanogaster
• Sequence 2: NP_150371.4
• Gene: Actn2 / 11472
• MGIID: 109192
• Length: 894
• Species: Mus musculus
• Alignment Length: 953
• Identity: 236/953 - (24%)
• Similarity: 403/953 - (42%)
• Gaps: 289/953 - (30%)

  Fly  1633 KLKEANKQRTYIAA--VK------------DLDFWLG---------EVESLLTTEDSGKD----- 1669
            |:...||...|||:  ||            ::...||         .::.:...|.|.|:
Mouse    96 KIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLW 160

  Fly  1670 ---------LASVQN-------------LMKKHQ--LVEADIVAHEDRIKDMN------------ 1698
                     ..::||             |:.:|:  |::...:..:|.|.::|
Mouse   161 CQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDI 225

  Fly  1699 ---NQADSLVESGQFDT--------------AGIQEKRQSINERYERICNLAAHRQARLNEALTL 1746
               ..|:.:|.:.:.|.              ||.::...:.|    |||.:.|..|.  ||.| :
Mouse   226 PKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAAN----RICKVLAVNQE--NERL-M 283

  Fly  1747 HQFFRDIADEESWIK------------------EKKLLVGSDDYGRDLTGVQNLKKKHK------ 1787
            .::.|..::...||:                  :|||    :|:       ::.::|||
Mouse   284 EEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKL----EDF-------RDYRRKHKPPKVQE 337

  Fly  1788 --RLEAELG--------SHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATR 1842
              :||....        |:.||.  :...|:.:.|::...     |||:...:.:.|.......|
Mouse   338 KCQLEINFNTLQTKLRISNRPAF--MPSEGKMVSDIAGAW-----QRLEQAEKGYEEWLLNEIRR 395

  Fly  1843 GQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDY-GDSMAAVQGLLKKHDAFETDFTAHKDRC 1906
            .::|:.  ..::|..:....|.|...|:|:|..:|| ..|:..|:.||:||:|||:|..||:||.
Mouse   396 LERLEH--LAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRV 458

  Fly  1907 SLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESW 1971
            ..|.....||.|...|...::..|||::..:.|.|..|..:|:.||
Mouse   459 EQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL------------------- 504

  Fly  1972 IDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILK 2036
                                                                             
Mouse   505 ----------------------------------------------------------------- 504

  Fly  2037 RHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCN 2101
                             .|.::||      ..|::|:|.|||:|:.||:|.|.|.|||.|....:
Mouse   505 -----------------ERTEKLL------ETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVH 546

  Fly  2102 SIEEIRALRDAHAQFQASLSSAEADFKALAAL----DQKIKSFNV---GPNPYTWFTMEALEETW 2159
            |||||::|..||.||:|:|..|:.:.:::.|:    ::.|:|:::   ..|||:..||:.|...|
Mouse   547 SIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKW 611

  Fly  2160 RNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQ---GTSMMEG 2221
            ..:::::..||..|.:|..||..|::||::||..||....|:         .|:.   ..|.::.
Mouse   612 DKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWI---------QNKMEEIARSSIQI 667

  Fly  2222 SGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDNRYT----EHSTVGLAQQWDQLD 2282
            :|:||.|:..|:.....:...:.::.|:|....|::|.|:.||::|    ||..||    |:.|.
Mouse   668 TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVG----WELLL 728

  Fly  2283 QLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVE 2347
            ....|..:.:|.||..|:..|::::.:.||...|.|||:.|:|.::|::|::||.::||||
Mouse   729 TTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL---- 789

  Fly  2348 EGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEE 2412
               .:.||..|:.:||||..|.|:.|.:|.|| ::||.:..:.|::..:|| |.|:|:||:..||
Mouse   790 ---GEAEFARIMTLVDPNGQGTVTFQSFIDFM-TRETADTDTAEQVIASFR-ILASDKPYILAEE 849

  Fly  2413 LYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYIDFTRTLF 2455
            |...|..|.|.||::||.|:|.|.|   :..||||..|:..|:
Mouse   850 LRRELPPDQAQYCIKRMPPYSGPGS---VPGALDYTAFSSALY 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742
		SPEC	1074..1287	CDD:238103
		SPEC	1182..1425	CDD:238103
		SPEC	1426..1638	CDD:238103	1/4 (25%)
		SPEC	1533..1744	CDD:238103	34/191 (18%)
		SPEC	1646..1850	CDD:238103	52/318 (16%)
		SPEC	1852..2062	CDD:238103	39/210 (19%)
		SPEC	1958..2176	CDD:238103	45/224 (20%)
		SPEC	2072..2296	CDD:238103	75/237 (32%)
		EFh	2311..2379	CDD:238008	27/67 (40%)
		EFhand_Ca_insen	2386..2456	CDD:400872	28/70 (40%)
		SPEC	48..258	CDD:238103
		SPEC	154..364	CDD:238103
		SPEC	261..470	CDD:238103
		SPEC	471..680	CDD:238103
		SPEC	682..893	CDD:238103
		Spectrin	893..>961	CDD:395348
Actn2	NP_150371.4	Actin-binding	1..254		24/157 (15%)
		CH_ACTN_rpt1	35..139	CDD:409063	10/42 (24%)
		CH_ACTN_rpt2	143..257	CDD:409065	14/113 (12%)
		Spectrin 1	281..391		22/128 (17%)
		Spectrin	281..391	CDD:395348	22/128 (17%)
		Spectrin 2	401..506		36/207 (17%)
		SPEC	402..629	CDD:238103	81/333 (24%)
		Spectrin 3	516..627		41/110 (37%)
		Spectrin 4	637..740		29/115 (25%)
		Spectrin	637..739	CDD:395348	29/114 (25%)
		PTZ00184	747..>851	CDD:185504	42/112 (38%)
		EFhand_Ca_insen	824..890	CDD:400872	28/70 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920