DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Spec and sptb

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	XP_002936942.2	Gene:	sptb / 100489265	XenbaseID:	XB-GENE-492725	Length:	2342	Species:	Xenopus tropicalis

Alignment Length:	1900	Identity:	487/1900 - (25%)
Similarity:	832/1900 - (43%)	Gaps:	371/1900 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-RDPTNL 81
            |::|.:.:...|.:......|:|..|:.||....|..|.:|:..||.||.|..:...: :|.|::
Frog   606 IKDRVQHLELCYQELVSLAAQRRHNLQQSRCLWKFFGDIEEVARWIREKEQIYTSMDFGKDLTSI 670

  Fly    82 QAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLW------------ 134
            ....:||:|||.|:......:......|::||..:|:||..|:.:::.:...|
Frog   671 SILQRKHRAFEDELKGLETNLQHTLKDGEQMIANKHYASPKIKEQIENIKVQWAQLKDLAAFRLK 735

  Fly   135 -----------------------------------------------------ELLLSRLAEKGL 146
                                                                 :::::|...:||
Frog   736 ILCDTENFFQFQVDADDLAARMQDTYRMMQSDDVGHDEYSTKILVKKQKDLLDDIMINRKVLEGL 800

  Fly   147 ----------------------------------------KLQQALVLVQFLRQCEEVMFWIKDK 171
                                                    |||.||.....|...:....|:.:|
Frog   801 SEVVQRFPEEFKTSPEIDSRLQKLRALFSDLASLADLRSQKLQDALSFYTVLGDIDACEMWMNEK 865

  Fly   172 ETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEEL 236
            |.::...|..:.||.:.|:|.:|:...::|.:...::.:||..|:.|::.|||.|..:.:..:.:
Frog   866 EKWLEKMEIPESLEDMGVVQHRFNTLDQEMGALGSQIQDVNTAANALIESGHPSRKKVKEDLDHM 930

  Fly   237 NEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEK-DVVLSSDDYGRDLASVQALQRKH 300
            |..|...:::...::..:..|..:..:..:.|||..||.|| .||.|..|.|.|||||.::|||.
Frog   931 NSRWTVFQEMVSQKRRAVDSALGLHNYGVECDETKNWIIEKIKVVESIQDLGSDLASVMSIQRKL 995

  Fly   301 EGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYY 365
            .|:||||||:|.|:..|..:||:|.:.|.|.:..|.|:..:|...|:.|....:.:::.|.||..
Frog   996 YGIERDLAAIEAKLINLQGDAQKLANDHPDQAQNILDRLIDINKKWEELQKALQNQEESLGESSK 1060

  Fly   366 LHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKL 430
            :.:||.|..|..:|:...:...:::::...:..||.|...|...|.:|:..|..|....::|.|:
Frog  1061 VQKFLVDLFDFETWLYRAQQATASEDIPTSLPEAEKLYANHLSLKDDIERHEPDFCDVVDTGNKV 1125

  Fly   431 LERE---HYAAAEIQEKLAALEND----KSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAK 488
            ...:   .|      |:|....||    .:.|..:|::|.....||::.|.|.:|.:|::..::.
Frog  1126 TSGQTDPQY------EQLDQRGNDIKEGWNDLHKMWDNREKSLSQCLEFQKFLKDAKQSEAILSN 1184

  Fly   489 QEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQM 553
            ||...|:.::..:|.:.:..:||||||..::...:|||........||.:.::..||....:...
Frog  1185 QEYTFAHIEVPTTLQASQTRLKKHEDFLATMENNDEKIVGTINHGKKLDEDKNVFADKALGKISF 1249

  Fly   554 LLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQ 618
            :..|.|....|:.:...||:|:...|.|..:|:|...||:||:..|.|.||....||:.|..|||
Frog  1250 IEERYAKNLNKAKEVSILLKDNCDLQNFLENCEELNIWINEKMLTAQDTSYDGARNLHSKWLKHQ 1314

  Fly   619 NFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQ 683
            .|:.||::||.|:|::...|.:|.:::...|..|:.::.|:..||:.|...:.:|...|.:|.:.
Frog  1315 AFKAELDSNKERLENLDKEGKQLAQEKEQFAPIISEKLSELHRLWDELETTTLQKEQSLFDAHRT 1379

  Fly   684 QQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFI 748
            :.:.:...|:..|:.::|.|:.|:|.|.|||||..|..||..:|       |:|:...:..::.:
Frog  1380 ELYEQRYADLNKWIKDMEQQVKSDDCGTDLTSVNILLNKHKRIE-------DQIQQKTIEMDQVL 1437

  Fly   749 ESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAAST 813
            ............||..::.|:..|...|.|||:.||.|.||.||.||||||..||:|:.|:|.|.
Frog  1438 PQASALGKEPDEKEPEINVRFLQLEPLMQERKRKLLSSKQVHQLHRDLEDEILWIQERLPLAESQ 1502

  Fly   814 NRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTL 878
            :.|.:|..||.|:||:|.:..||..|..|:.:|:...:::..|.......|.::.::|:|.|:.|
Frog  1503 DYGNNLQTVQMLMKKNQTLQKEIAGHSPRIEDVLMRAKHIEHDADIDDQPIEKKRKSLEESWDNL 1567

  Fly   879 KEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLE 943
            :::.::|::.|..:|:||.|:.||.|||:|:.|::....|.:..|||:|..|:||||..|...:|
Frog  1568 QKQIAEREKHLLQALEAHHYYMDAGEAEAWIDEQQLYLIGDEQPKDEESVVAMLKKHLNLQHAVE 1632

  Fly   944 AFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWW 1008
            .:|..|:.|.:||:.....|.|
Frog  1633 HYGKNIKDLADQAQKLLALEHP------------------------------------------- 1654

  Fly  1009 KVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETV 1073
                                           |:..|.:.|..|..||..|..:|.|::.||:...
Frog  1655 -------------------------------DSERITRHQGNIEKQYAALRDMADEKRQKLDNIY 1688

  Fly  1074 KAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKA-NEVRLANMNEIA 1137
            ..:.|.||..||.|||.:::..|. :..:|:||:.|.:|:.||.||..:... .:.|:.|:|.:.
Frog  1689 HMFQLRREVEDLEQWIAERDVKAS-SQEMGQDLDHVSILRDKFRDFARETGVIGQERIDNVNILI 1752

  Fly  1138 VQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKAN 1202
            .||...|..:||: |.....:|||.|.:|..|...:...|.:::|:.:|..|..|....|.||..
Frog  1753 EQLIDAGHADAAM-IAEWKDNLNESWADLLELIDTRVQLLSASYELHKFFYDGTEILSMIEEKHK 1816

  Fly  1203 ALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDT-AEQTYAKQKEIN 1266
            .| .:|||.|:.:.|:|.|.|...|||:..:..:::...:||.||..::..| |.....|::|:.
Frog  1817 EL-PEDLGGDVHTAQSLHRVHTAFERDIHFIGSQVQHFQDTAARLYAAYAGTQAVDIQKKEQEVV 1880

  Fly  1267 EMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQA 1331
            |.|..::.....|:.:|:.:.:..||.|..|||:.|:.:|:..:.:.|...|::..|.||:.||
Frog  1881 EAWKGLLDACDGRRTELISAAEKFRFFSMVRDLMLWMENMIRQIETQEKPRDISSVEYLIKYHQ- 1944

  Fly  1332 RRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEI 1396
                                           |.:.||:||..|:.|....||.||..||.||.||
Frog  1945 -------------------------------ELKAEIEARNVTYTACVDLGNTLLARNHPASEEI 1978

  Fly  1397 KEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVE 1461
            |||:..|.:.||::.:.|.:|...|...|::..:.||..:||||:.::|.:|.:....|:..:||
Frog  1979 KEKLVQLEERREEMMEKWHKRWDWLSILLEVCQFARDASMAESWLISKEPYLYSTYVGNSVDDVE 2043

  Fly  1462 ALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSR 1526
            .||::||.|:|                          |.|..|:|...|||...|:  |:|.|.
Frog  2044 KLIRRHESFEK--------------------------STLTWEERFSALERLTTLE--LLEVRK- 2079

  Fly  1527 LGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLA 1591
                  .|:..|          .::.:|.|...|:.|..:.:.|.|:..|.|:.|
Frog  2080 ------YQEAKR----------HEMLMAAESEMKETAQKEQQFQTHEEKEHEVKA---------- 2118

  Fly  1592 MGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWL-- 1654
                :|.....|...:.::.||..|.:    :|.:|.||. :.|...::.|:..:::..::.:
Frog  2119 ----IIHAAPDSPVLEELKPRLPSITE----VTEETKEKE-EEKITQEEYTHTESMEQTEYSILD 2174

  Fly  1655 ---GEVESLLTTEDSGKDLASVQN---LMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTA 1713
               .::|:.....|||.. :|:|:   |.:||.|        :..:|...|
Frog  2175 PETRQIEATTLPTDSGSS-SSIQHQGYLNRKHDL--------DGTLKKAAN-------------- 2216

  Fly  1714 GIQEKRQSINERYERICNLAAH-----RQAR---LNEA------LTL---------------HQF 1749
                  :|.|..|   |.|..|     :.|:   ||||      |.|               |.|
Frog  2217 ------RSWNNVY---CVLKNHDLYFYKDAKCFALNEAFQGEGPLPLRNASCEIVADYKKKKHVF 2272

  Fly  1750 FRDIADEESWIKEKK 1764
            ...:.|...|:.:.|
Frog  2273 RLRLGDGNEWLFQAK 2287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742	0/51 (0%)
		SPEC	1074..1287	CDD:238103	65/214 (30%)
		SPEC	1182..1425	CDD:238103	72/243 (30%)
		SPEC	1426..1638	CDD:238103	49/211 (23%)
		SPEC	1533..1744	CDD:238103	45/232 (19%)
		SPEC	1646..1850	CDD:238103	29/155 (19%)
		SPEC	1852..2062	CDD:238103
		SPEC	1958..2176	CDD:238103
		SPEC	2072..2296	CDD:238103
		EFh	2311..2379	CDD:238008
		EFhand_Ca_insen	2386..2456	CDD:400872
		SPEC	48..258	CDD:238103	53/315 (17%)
		SPEC	154..364	CDD:238103	64/210 (30%)
		SPEC	261..470	CDD:238103	67/216 (31%)
		SPEC	471..680	CDD:238103	62/208 (30%)
		SPEC	682..893	CDD:238103	66/210 (31%)
		Spectrin	893..>961	CDD:395348	28/67 (42%)
sptb	XP_002936942.2	SAC6	47..>394	CDD:227401
		SPEC	421..635	CDD:238103	6/28 (21%)
		SPEC	639..846	CDD:238103	30/206 (15%)
		SPEC	743..952	CDD:238103	29/208 (14%)
		SPEC	954..1166	CDD:238103	67/217 (31%)
		SPEC	1169..1269	CDD:197544	25/99 (25%)
		SPEC	1273..1475	CDD:238103	64/208 (31%)
		SPEC	1477..1688	CDD:238103	78/284 (27%)
		SPEC	1583..1795	CDD:238103	74/287 (26%)
		SPEC	1796..2018	CDD:238103	75/254 (30%)
		SPEC	2011..>2065	CDD:197544	21/79 (27%)
		PH_beta_spectrin	2197..2296	CDD:269975	23/121 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010