DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and sptbn4

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_002938861.2 Gene:sptbn4 / 100488521 XenbaseID:XB-GENE-1013360 Length:2545 Species:Xenopus tropicalis


Alignment Length:1986 Identity:495/1986 - (24%)
Similarity:853/1986 - (42%) Gaps:336/1986 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-RDPTNL 81
            :::|.|||..::.:.:......::||:::..|..|..|..||..|:.:..:..|.:.: .|..:.
 Frog   715 LRQRMEQVRLKWENLQKACDNHQQKLQEASSFYQFSADTMELAGWLQDTYRLVSSDDFGHDEYST 779

  Fly    82 QAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGL 146
            |:.::||:|...|:..|..|::.|.....| :..::.....:|:.:.|:.:|:..::...|.:..
 Frog   780 QSLVKKHRAETVEIEKHKVAVLGLRQQLSE-LGAEYRDQVDVQITIVEVEQLYGEVVEVSALRSQ 843

  Fly   147 KLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEV 211
            .||.||.:.:...:......||.:||.::...|..|.||.|||:|.:|:...::|.|...||.:|
 Frog   844 WLQDALDVYKMFGEVNSCEVWIDEKEQWLMKMEIPQRLEEVEVVQHRFESLDQEMNSLMGRVLDV 908

  Fly   212 NQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAE 276
            ||:..:|::.|||....:...::.||..|.|:.:|...|:|:|.....:|.:..:.:|..:.|.|
 Frog   909 NQIVQQLLEGGHPSSSEVRACQDHLNSRWNRIVELVEQRKEQLSSVLRLQNYFLECNEVKSQIRE 973

  Fly   277 KDVVLSSDDYGR-DLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQA 340
            |...:.:...|. :|..|.:||||...:|..|.|||.|:..|..:|:.|.:.|...:.::.....
 Frog   974 KRRTMETPQCGSGELGGVLSLQRKLSSMEAALLALEPKLVQLQQDAEILATSHPSQAMEVLVHFE 1038

  Fly   341 EIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLER 405
            ||:..|.:|....:..:..|..:..|.:|:.|..:.::|:...:..::|:||..::|.||.||..
 Frog  1039 EISGEWDALKRTLQGCEDSLTVANKLQQFIQDLDNFLTWLVKTQTAVAAEELPSNLAEAERLLGL 1103

  Fly   406 HQEHKGEIDAREDSF-KLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRILYEQC 469
            |...|.||...|:.: |:...:....||........:|:.|..||...:.||.:||:||.:..|.
 Frog  1104 HGSLKEEISRYEEEYNKIQAVNDLLSLEEADLPYLSLQQWLQKLEVGWNKLLQMWENRREVLVQA 1168

  Fly   470 MDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFAT 534
            ....||.||.:||:..:..||:.||:.:|.::::.|||.||||:||..::....:|:........
 Frog  1169 HIFHLFLRDFKQAEACLNTQESTLAHVELPNTVEGVEAAIKKHKDFVTTMELNVQKVSVAVEAGE 1233

  Fly   535 KLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFA 599
            .||...:..||.|.:|...:..|.......:.|..|.|.|..:.|.|.::|:|...|:.||...|
 Frog  1234 SLIRLGNVFADHVQERISAIQKRSQRNTALAQKWLQRLRDHLQLQHFLQNCNELDAWVHEKTLMA 1298

  Fly   600 TDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWE 664
            .|.|.......:.|..|||.|..||:.||..:|.|...|.:||:::...|..:..:::||...|.
 Frog  1299 RDSSRDLSQKPHKKWLKHQAFMAELSQNKGWLEKIEKEGQQLIQEKPELAGVVKKKLEEIRQCWV 1363

  Fly   665 TLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEA- 728
            .|..::..|..:|.:|.:..|..:...::...|..::.||...|...|::||....|:...:|: 
 Frog  1364 ELESSTQAKAQQLFQATKADQVVQNYSELGKRLYHLKEQLQPVDPVPDVSSVNTQLKRLETMESQ 1428

  Fly   729 ------DVMAHQDRIES--IKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLD 785
                  :|...|.:|.|  ::||:.|.:|          .|:..:......|..|:.||::.||.
 Frog  1429 MEEWYKEVGELQAQIASLPLEVASQKALE----------EKQNEVGTTIVRLIEPLKERRRILLA 1483

  Fly   786 SLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSG 850
            |.:|.|:.||||||..|::|:.|:|.|...|.:|..||.||||:|.:..||..|..|:.:::...
 Frog  1484 SKEVHQVTRDLEDEIFWVQERLPLATSKEHGSNLQIVQQLIKKNQNLRREIQVHSPRVDDILERA 1548

  Fly   851 ENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPI 915
            ..:...:...::.:|...|:|.|.||.|::::.:|:|.||.:.|..||:.|..|.|:|:.|:|.:
 Frog  1549 GAIASIRTPEAEGVRLGYESLGEMWNMLRDETERRQQLLDITYQVQQYYFDVGEVETWLSEQELL 1613

  Fly   916 ATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYD 980
            ....:.||||.|:..|||||..|...:|.:..||..|..|   ||                    
 Frog  1614 MMNDEKGKDEQSTLQLLKKHLMLEQTIENYEETIAQLSRQ---CR-------------------- 1655

  Fly   981 YTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIA 1045
                             |||                           |.|...|:|       |:
 Frog  1656 -----------------TLL---------------------------DLGHPDSEQ-------IS 1669

  Fly  1046 KRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVE 1110
            |||:||:..|.:|..|..||:.:|.:....:.|.||..:|.|||.:||..|...: :|:|.|.|.
 Frog  1670 KRQSQIDRLYVSLKDLVDERKGRLEQQYWLFQLSREVDELEQWIAEKEVVAGSPE-LGQDYEHVT 1733

  Fly  1111 VLQKKFDDFNDDL-KANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKA 1174
            :||:||.:|..:. ...:.|::.:|::..:|...|.::||: |......:||.|.:|..|...::
 Frog  1734 LLQEKFTEFATETGSVGQERISAVNQMVDELIDFGHSDAAI-IAEWKDGVNEAWADLLELMETRS 1797

  Fly  1175 SQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQ 1239
            ..|.::||:.:|..|..|....:.||...|......:...|..:|||.....|.|:..|..::||
 Frog  1798 QMLAASHELYKFFNDCKEVLSQVEEKKQRLPEVKAQEAKLSAGSLQRILSSFEHDIQVLVTQVRQ 1862

  Fly  1240 LDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWI 1303
            |.|.|.:|...:. :.|......::|:...|.:::|.....:.::..:.|..:||:..|||::|:
 Frog  1863 LQENAAQLRTVYAGENAAAIVTSEQEVMRAWKELLTSCEDCRLQITSTTDRIKFLNLVRDLISWM 1927

  Fly  1304 NSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEI 1368
            .|:...:.::|...||:..|.|:..||          |:.|                      ||
 Frog  1928 ESITCQIGAEEKPRDVSSVEVLMSYHQ----------GLKS----------------------EI 1960

  Fly  1369 DARAGTFGAFEQFGNELLQANHYASPEIKEKIEDL-AKAREDLEKAWTERRLQLEQNLDLQLYMR 1432
            ::|........:.|..|:.....:|.|||:.::.| ||.:|.||| |.:....|:|.|::..:.:
 Frog  1961 ESRNKRIADCVELGKTLVLNKRPSSDEIKQSLDRLMAKKKEMLEK-WNKHWEWLQQMLEVHQFAQ 2024

  Fly  1433 DCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQ--TVADQLIAQ- 1494
            :..:|::|::|:|..:.:.:..|:...||.||::||.|.|.....|::.::|:  |..::|.|: 
 Frog  2025 EAGVADAWLTAQEPIVKSPELGNSVDEVEQLIRRHEAFRKTAAVWEERFSSLRRLTTLEKLKAEQ 2089

  Fly  1495 -NHYASNLVDEK----------------RKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADE 1542
             ...|:.|:..|                |:.|.|          ...::|..::.|........|
 Frog  2090 SKQPATPLLGRKVFPDTTDYSARPSPLSRQTVYE----------NSETKLDQKEALSIPDGGQQE 2144

  Fly  1543 IENWIAEKLQLATEESYKD--PANIQSK--HQKHQAFEAELAA----NADRIQSVLAMG-GNL-I 1597
            |....|||.:.......:|  |..:|.|  |.:.:..:..|||    .|::.:...|.| .|| :
 Frog  2145 IRRARAEKGETRVGYVRQDIKPERLQPKMDHVETKVADKPLAAQEVERAEKTEIKFAQGMANLTV 2209

  Fly  1598 DKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLT 1662
            :|.:..||....:||             ...|:.|:.:|:::|.|                    
 Frog  2210 EKPEIKGSRHTERKR-------------DRHERRLERQESSEQET-------------------- 2241

  Fly  1663 TEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYE 1727
                           .|.:..|.....||.|::   .|..|..|:.:      ||:.:...:|:|
 Frog  2242 ---------------PKQEPPERRRDRHEKRLE---RQGSSEQETPK------QEQSERRRDRHE 2282

  Fly  1728 RICNLAAHRQARLNE------------ALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQ 1780
            |    ...||..:.:            ..||......:.::|::.....   |.|...|...||.
 Frog  2283 R----RTERQDTIEQDKPRTEPEKQAGKATLADIVEQLQEKEAFQNSSG---GQDSPARVPNGVD 2340

  Fly  1781 NLKKKHKRL-------------------------EAELGSHEPA----------IQAVQEAGEKL 1810
            .|.::..|.                         ||......||          ...:|:.| .|
 Frog  2341 KLPERTTRPDRPRARDRPKPRRRPRPKDPNQPPGEARRSRSAPAQSSAPPPPPPTHTIQQEG-YL 2404

  Fly  1811 MDVSNLGVPEIEQRLKALNQAW-----------------AELKNLAATRGQ-------------- 1844
            .....|..|.    .||.|::|                 |:.::..||.|.              
 Frog  2405 FRKHELDGPS----KKASNRSWINLYCVLNKGDLGVYKDAKSQSSGATHGGEPLLNLLGASCEVA 2465

  Fly  1845 ----------KLDESLTYQQFLAQVEEEEA---WIT 1867
                      || .|...::||.|.::||.   |||
 Frog  2466 SEYKKKKFVFKL-RSTDGREFLFQAKDEEEMKNWIT 2500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 3/51 (6%)
SPEC 1074..1287 CDD:238103 57/214 (27%)
SPEC 1182..1425 CDD:238103 60/244 (25%)
SPEC 1426..1638 CDD:238103 52/241 (22%)
SPEC 1533..1744 CDD:238103 44/232 (19%)
SPEC 1646..1850 CDD:238103 44/291 (15%)
SPEC 1852..2062 CDD:238103 8/19 (42%)
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 57/210 (27%)
SPEC 154..364 CDD:238103 59/210 (28%)
SPEC 261..470 CDD:238103 58/210 (28%)
SPEC 471..680 CDD:238103 63/208 (30%)
SPEC 682..893 CDD:238103 63/219 (29%)
Spectrin 893..>961 CDD:395348 26/67 (39%)
sptbn4XP_002938861.2 SAC6 48..>454 CDD:227401
SPEC 425..637 CDD:238103
SPEC 642..849 CDD:238103 29/134 (22%)
SPEC 746..955 CDD:238103 57/209 (27%)
SPEC 956..1169 CDD:238103 58/212 (27%)
SPEC 1171..1379 CDD:238103 63/207 (30%)
SPEC 1276..1484 CDD:238103 57/217 (26%)
SPEC 1488..1588 CDD:197544 34/99 (34%)
SPEC 1592..1804 CDD:238103 78/287 (27%)
SPEC 1804..1906 CDD:351773 25/101 (25%)
SPEC 1915..>2079 CDD:238103 51/196 (26%)
PTZ00121 <1985..2345 CDD:173412 93/434 (21%)
PH_beta_spectrin 2401..2505 CDD:269975 23/106 (22%)
DUF5069 <2473..2540 CDD:374811 11/29 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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