DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sptbn2

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_012817859.1 Gene:sptbn2 / 100486199 XenbaseID:XB-GENE-1008690 Length:2437 Species:Xenopus tropicalis


Alignment Length:1754 Identity:485/1754 - (27%)
Similarity:845/1754 - (48%) Gaps:233/1754 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAAS-EESYRDPTN 80
            :|:||.::|..::.:.:.....:..:|.::..:..|:.||::.|:||.:.|:..| .|...|..:
 Frog   753 EIEERIKEVKGQWTEMEALAEDRERRLREAYSYYQFQADANDAEAWILDTLRLVSTSEVGHDEYS 817

  Fly    81 LQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKG 145
            .|..::||:..|.|:.:|..||.:|....:. :...:..|..:..||..|.:.:|.|::..|.:.
 Frog   818 TQTLVKKHKEIEEEILSHRPAIDALHEQARG-LPPAYSHSPEVDGRLPALEQRYEELVALAAHRK 881

  Fly   146 LKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTE 210
            ..||.:|.|.:...:.:..:.||.:||.::...|..:.||.:||:|::|:..:.:|.:...|:..
 Frog   882 QALQDSLALHKMFSEADACLLWIDEKEQWLNVTEIPEKLEDLEVVQQRFETLEAEMNNLASRIAS 946

  Fly   211 VNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIA 275
            ||::|.:|:.......::|...:::||..|...::|...::..|..|.:||.::.:.:|||.|:.
 Frog   947 VNEVAGQLLTTDQRNENSIRDMQDQLNSRWNEFRKLVDQKKGALDSALDIQNYHLECNETVCWMR 1011

  Fly   276 EK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQ 339
            || .|:.|:...|.|||.|.|||||..|:||||.|::.||..|.:||::|...|...:..|..:.
 Frog  1012 EKTKVIESTQSLGNDLAGVTALQRKLTGMERDLKAIQGKVGDLRSEAEKLADGHPQKAPAIIGRL 1076

  Fly   340 AEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLE 404
            ::|...|..|....:.|::.|.|:..|..||.|..|..||::..:..::::::..|:|.||.||.
 Frog  1077 SDIDETWGELKDTMKRREETLGEASKLQGFLRDLDDFQSWLSRAQTAVASEDVPADLAEAERLLA 1141

  Fly   405 RHQEHKGEIDAREDSFKLTTESGQKLLEREHYAA-AEIQEKLAALENDKSSLLSLWEDRRILYEQ 468
            :|:..|.|||.....:....:.|:::...:..|. ..:|::|.||:...:.|..:||:|..|..|
 Frog  1142 QHEGIKNEIDHYGADYHRVRDVGEEVTRGQTDAQYMFLQQRLKALDTGWNELGQMWENRHQLLSQ 1206

  Fly   469 CMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFA 533
            ....|.|.:||:|.:.::..||..|::.::..:|.:.||.||:||||..::.|.||||:.|....
 Frog  1207 GHSFQQFLKDTKQVEGFLNNQEYVLSHTEMPSTLQAAEAAIKRHEDFLTTMDANEEKIQGLVESG 1271

  Fly   534 TKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKF 598
            .|||:.|:..::.:.::...:..|....|:.:|:....|:|:...|.|.:||.|...||:||:..
 Frog  1272 RKLIEEQNVNSEKIQEKVTSIDERHKKNQKTASEVLTRLKDNRDLQHFLQDCQELTLWINEKMLT 1336

  Fly   599 ATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLW 663
            |.|.||.:..||:.|.||||.|..||.:||..::.|...|.:|:.::......:..::..:..||
 Frog  1337 AQDVSYDEARNLHSKWQKHQAFMAELASNKDWLDKIDKEGQQLMSEKPELEPVVREKLDTLHKLW 1401

  Fly   664 ETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEA 728
            ..|...:..|...|.:|.:.:.|.::...:|.||..:|.||.|:.:|||||||..|..|..:||.
 Frog  1402 NDLESTTQSKAQCLFDANRAELFTQSCSALESWLQNLESQLQSDHYGKDLTSVNILLNKQQMLEN 1466

  Fly   729 DVMAHQDRIESIKVAANKFIESGHFDAD--NIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQ 791
            .:...:..:|:|:..|...   |..||:  .:.:|..:::.:::.|.||:.:|::.||.|.:..|
 Frog  1467 QMEVREKELEAIQSQAQAL---GQEDANIVEVDSKHKDVADKFSKLRAPLNKRRKLLLASKEGHQ 1528

  Fly   792 LFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKD 856
            ..||||||..|::||.|:|.||:.|:||..||.||||:|.:..||..|:.|:.:::..|::|::|
 Frog  1529 FNRDLEDEILWVKEKMPMAISTDHGKDLPTVQLLIKKNQTLQKEILGHQPRIDDILERGKSMIQD 1593

  Fly   857 QPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDY 921
            ......:|.:||..|:..|..|..:..:|...|::||.|.|::|||.|||:||.|:|......:.
 Frog  1594 SSLDPQEIEERLGLLKSTWEELAAEGGKRHARLEESLAAQQFYADAAEAEAWMGEQELHMMSEEK 1658

  Fly   922 GKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSP 986
            .|||..::|:||||  ||.:        |||.:.|.|..|                         
 Frog  1659 AKDEIGAQAMLKKH--LVME--------QALDDYADNIHQ------------------------- 1688

  Fly   987 REVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLV-----DNHSIAK 1046
                                                        |:.|.:::|     ::..|..
 Frog  1689 --------------------------------------------LANSSRDMVSRGHPESDRITL 1709

  Fly  1047 RQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEV 1111
            ||.|::..|.:|..||.|||.||.|..:...|.|:..||..||.::|..| .:..:|:|.|.|.:
 Frog  1710 RQGQVDKLYASLKDLAEERQGKLQEHHRLCQLKRDVEDLEHWISEREVVA-ASHELGQDYEHVTM 1773

  Fly  1112 LQKKFDDFN-DDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKAS 1175
            |:.||.:|: |.....:.|:..:|.:|..|.|.|.:|.| .:......|||.|.:|..:...::.
 Frog  1774 LRDKFREFSRDTSNIGQERVDAVNLMADDLISSGHSENA-TVADWKDQLNEAWADLLEMIDTRSQ 1837

  Fly  1176 QLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQL 1240
            .|.:::|:.||::|..||...|.:|...: .::.|:||.:.:.:||.|...|.|:.||..:::|:
 Frog  1838 MLAASYELHRFYQDAKETLGQIQDKQKQI-PEETGRDLNTAEAMQRMHTAFEHDIQALSAQVKQV 1901

  Fly  1241 DETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWIN 1304
            .|.|:||.:::. :.|...:..::.::|.|.::...|.||::.|||:.:..||....|||:.|::
 Frog  1902 QEDASRLQKAYAGEKAADIHRHEQAVSEAWGELQNASGARRQLLLDTVEKFRFFRMVRDLMLWMD 1966

  Fly  1305 SMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEID 1369
            .:..|:.:.|...||:.|:.:|:.|          |||                      :.|:|
 Frog  1967 DINLLIDAQEKPRDVSSADLVIQNH----------LGI----------------------KAEVD 1999

  Fly  1370 ARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDC 1434
            |||.:|......||.||:.|||||.:|.||:|.|.:.|::.|..|.::...|....::.::.||.
 Frog  2000 ARADSFTTCIDLGNSLLEKNHYASDKISEKLEQLQERRQETENKWKDKMAWLRVVHEVLMFGRDA 2064

  Fly  1435 ELAESWMSAREAFLNADDDANAGGN---VEALIKKHEDFDKAINGHEQKIAALQ--TVADQLIAQ 1494
            .:||:|::::|..:.:.:   .|||   ||:|||:||.|.||::..:::...|:  |..:::..:
 Frog  2065 SVAEAWLASQEPIVRSSE---LGGNVDEVESLIKRHEAFQKAVSTWDERFVLLEKLTTLEEIEMR 2126

  Fly  1495 NHYASN-----------LVDEKRKQVL-------------------ERWRHLKEGLIEKRSRLG- 1528
            ......           .|:|.|::|:                   ||...::....|:.|..| 
 Frog  2127 RKREEEERKKRPPTPPLPVEEPREEVVKTQVSQTIEGQTDPANILQERINGMQNSFQEQVSVNGL 2191

  Fly  1529 -DEQTLQQFSRDADEIENWIAEKL--------------------------QLATEESYKDPANIQ 1566
             .|....|.|.|...:|:.|:|..                          ||....:: .|.|:|
 Frog  2192 CTESDSPQPSSDTQRLEDSISENQGPEQSDVTNGARTEVITKDGSPTPSPQLVARPTF-SPINLQ 2255

  Fly  1567 SK-------------------HQKHQA-FEAELAANA--DRIQSVLAMG--GNLIDKKQCSG--- 1604
            ..                   |:|.:. ...:.|||.  ..:...|..|  |...|.|..:.   
 Frog  2256 YSTLPSSPTEPLASEQMEGMLHRKQEMDSHNKKAANRSWQNVYCALKRGSLGFYKDAKSAASGVS 2320

  Fly  1605 --SEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKD---LDFWLGEVESLLTT 1663
              ||.:||....|.:...:|...|...| |.|.:.   :.|:...||   :..|:..:.:.||:
 Frog  2321 YHSEPSVQLNGAQCSVAHDYKKRKNVFK-LSLLDG---KEYLFQAKDEAEMSSWMRVINASLTS 2380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 63/214 (29%)
SPEC 1182..1425 CDD:238103 72/243 (30%)
SPEC 1426..1638 CDD:238103 62/303 (20%)
SPEC 1533..1744 CDD:238103 37/189 (20%)
SPEC 1646..1850 CDD:238103 5/21 (24%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 53/210 (25%)
SPEC 154..364 CDD:238103 65/210 (31%)
SPEC 261..470 CDD:238103 69/210 (33%)
SPEC 471..680 CDD:238103 65/208 (31%)
SPEC 682..893 CDD:238103 72/212 (34%)
Spectrin 893..>961 CDD:395348 28/67 (42%)
sptbn2XP_012817859.1 CH 94..197 CDD:237981
CH 213..316 CDD:237981
Spectrin 341..451 CDD:278843
SPEC 465..563 CDD:197544
SPEC 568..783 CDD:238103 5/29 (17%)
SPEC 681..888 CDD:238103 33/135 (24%)
SPEC 785..994 CDD:238103 53/209 (25%)
SPEC 997..1206 CDD:238103 68/208 (33%)
SPEC 1210..1419 CDD:238103 65/208 (31%)
SPEC 1420..1630 CDD:238103 72/212 (34%)
SPEC 1527..1734 CDD:238103 85/285 (30%)
SPEC 1632..1843 CDD:238103 76/291 (26%)
SPEC 1844..2051 CDD:238103 71/239 (30%)
SPEC 2060..>2117 CDD:197544 20/59 (34%)
PH 2272..2378 CDD:278594 24/109 (22%)
PH_beta_spectrin 2272..2377 CDD:269975 24/108 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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