DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and actn3

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001135513.1 Gene:actn3 / 100216053 XenbaseID:XB-GENE-920242 Length:896 Species:Xenopus tropicalis


Alignment Length:1088 Identity:250/1088 - (22%)
Similarity:444/1088 - (40%) Gaps:296/1088 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1464 IKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLV-----DEKRKQVLERW--RHLKEGLI 1521
            |:.|..:..:.|         .|..|.::.:..:..:|:     ::::::....|  .||:    
 Frog     4 IETHIQYSNSYN---------MTEEDYMVQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLR---- 55

  Fly  1522 EKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRI 1586
                :.|     .|.....::..|.:...|.|......:.|...:.|.:.|:      .||.::.
 Frog    56 ----KAG-----TQIENIEEDFRNGLKLMLLLEVISGERLPKPDKGKMRFHK------IANVNKA 105

  Fly  1587 QSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQ-WEYL---------THKTT----------EKS 1631
            ...:|..|   .|....|:|:.|...|...... |..:         ..:|:          .|:
 Frog   106 LDFIASKG---VKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT 167

  Fly  1632 LKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQ--LVEADIVAHEDRI 1694
            ...:..|.|..:|:       |              ||..::..|:.:|:  |::...:..:|.|
 Frog   168 APYRNVNVQNFHIS-------W--------------KDGLALCALIHRHRPDLIDYSKLRKDDPI 211

  Fly  1695 KDMNN---------------QADSLVESGQFDT--------------AGIQEKRQSINERYERIC 1730
            .::|.               .|:.:|.:.:.|.              ||.::...:.|    |||
 Frog   212 GNLNTAFDVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAAN----RIC 272

  Fly  1731 NLAAHRQARLNEALTLHQFFRDIADEESWIK------------------EKKLLVGSDDYGRDLT 1777
            .:.|..|.  ||.| :.::.:..::...||:                  :|||    :|: ||..
 Frog   273 KVLAVNQE--NEKL-MEEYEKLASELLEWIRRTIPWLENRTPEKNMGAMQKKL----EDF-RDYR 329

  Fly  1778 GVQNLKKKHKRLEAELG----------SHEPAIQAVQEAGEKLMDVSNL--GVPEIEQRLKALNQ 1830
            .|....:..::.:.|:.          |:.||.  :...|:.:.|::|.  |:.::|:..    :
 Frog   330 RVHKPPRVQEKCQLEINFNTLQTKLRLSNRPAF--MPSEGKMVSDIANAWKGLEQVEKGY----E 388

  Fly  1831 AWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDY-GDSMAAVQGLLKKHDA 1894
            .|..|:.....|.:.|.|     :|..:....|:|...|::||:..|| ..|:..::.|::||:|
 Frog   389 EWLLLEIRRLERLEHLAE-----KFKQKASLHESWTRGKEELLTQRDYESASLMEIRALVRKHEA 448

  Fly  1895 FETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYL 1959
            ||:|..||:||...|.....||.|...|...|:..|||.:..:.|||..|..:|:.||       
 Frog   449 FESDLAAHQDRVEQIAAIAQELNELDYHDAASVNSRCQAICDQWDNLGTLTQKRRDAL------- 506

  Fly  1960 QFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLI 2024
                                                                             
 Frog   507 ----------------------------------------------------------------- 506

  Fly  2025 NASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFEN 2089
                                         .|.::||      ..|::|||.|||:|:.||:|.:.
 Frog   507 -----------------------------ERVEKLL------ETIDQLYLEFAKRAAPFNNWMDG 536

  Fly  2090 AEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALD---QKI-KSFNV---GPNPY 2147
            |.|||.|....:|||||::|..||.||:|:|..|:.:..::..:.   ||| :::.:   |.|||
 Frog   537 AVEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADKEKMSILGIQAEIQKIAQTYGIKLSGINPY 601

  Fly  2148 TWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYN 2212
            |..|...:...|..:::::..||..|.:|..||:.|::||::||..||:...|:...      ..
 Frog   602 TNLTHLDISNKWETVKQLVPHRDQTLQEELARQQANERLRRQFAAQANVIGPWIQSK------ME 660

  Fly  2213 RQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQ 2277
            ..|...::.|.|||.|:..|:.....:.:.:.::.|:|....|::|.||.||::|.:|...:...
 Frog   661 EIGRISVDISASLEDQMNHLKQYEQNIISYKSNIDKLEGDHQLIQESLIFDNKHTNYSMEHIRVG 725

  Fly  2278 WDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYD 2342
            |:||.....|..:.:|.||..|:..|:|::.:.||...|.|||:.::|.::..:|::||.::|||
 Frog   726 WEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKRNGMMDPDDFRACLISMGYD 790

  Fly  2343 LPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEEIENAFRAITAADRPY 2407
            |..|       ||..|:.:||||..|.|:.|.:|.|| ::||....:.|::..:|: |.|:|:.|
 Frog   791 LGEV-------EFARIMTLVDPNNTGVVTFQAFIDFM-TRETAETDTAEQVMASFK-ILASDKSY 846

  Fly  2408 VTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYIDFTRTLF 2455
            :|.|||...|..:.|:||:.||..::   ....|..||||:.|:..|:
 Frog   847 ITIEELRRELPPEQAEYCITRMTKYT---GADAISGALDYMSFSSALY 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742
SPEC 1074..1287 CDD:238103
SPEC 1182..1425 CDD:238103
SPEC 1426..1638 CDD:238103 29/200 (15%)
SPEC 1533..1744 CDD:238103 44/261 (17%)
SPEC 1646..1850 CDD:238103 46/264 (17%)
SPEC 1852..2062 CDD:238103 39/210 (19%)
SPEC 1958..2176 CDD:238103 45/224 (20%)
SPEC 2072..2296 CDD:238103 74/230 (32%)
EFh 2311..2379 CDD:238008 26/67 (39%)
EFhand_Ca_insen 2386..2456 CDD:400872 23/70 (33%)
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103
Spectrin 893..>961 CDD:395348
actn3NP_001135513.1 SAC6 38..>378 CDD:227401 65/396 (16%)
SPEC 404..631 CDD:238103 83/338 (25%)
Spectrin 639..741 CDD:334073 28/107 (26%)
FRQ1 752..862 CDD:227455 42/118 (36%)
EFhand_Ca_insen 826..892 CDD:312305 23/70 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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