DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and sptbn1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001362280.1 Gene:sptbn1 / 100145120 XenbaseID:XB-GENE-989148 Length:2358 Species:Xenopus tropicalis


Alignment Length:1877 Identity:507/1877 - (27%)
Similarity:875/1877 - (46%) Gaps:309/1877 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ENFTPKEVKILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEK 66
            |.:.|.:.::      |::|...:...|.:......::|.:||:|||...|..:..|.|.||.||
 Frog   597 EGYKPCDPQV------IRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREK 655

  Fly    67 LQAASEESY-RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDEL 130
            .|..|.:.| :|.|::.....||:|||.|:|..|..::.....|:|||.:.||.||.|:.|:.::
 Frog   656 EQILSSDDYGKDLTSVVRLYCKHKAFEDEMSGRSGHLLQTIKEGEEMIAEDHFGSEKIRERIKDI 720

  Fly   131 HKLWELL--LSRLAEKGLK---------------------------------------------- 147
            .:.|..|  ||.:.:|.|:                                              
 Frog   721 QEQWANLEHLSAIRKKRLEDTTSSYQFQADADDVDAWMLDILRIVSSSDVGHDEYSTQSLVKKHK 785

  Fly   148 ---------------------------------------------------------LQQALVLV 155
                                                                     ||.||.|.
 Frog   786 DVAEEIANYRSTIDALHEQAAALPEERFNSTDVQNRLSGIEERYKELAELARLRKQALQDALTLY 850

  Fly   156 QFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQ 220
            :...:.:....||.:||.::...:..:.||.:||:|.:|:..:.:|.:|..||..|||:|.:|:.
 Frog   851 KMFSEADACELWIVEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLIH 915

  Fly   221 DGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEK-DVVLSSD 284
            .|||....|..::::||..|.:.::|....::.|..|..||.::.:.:||.:||.|| .|:.|:.
 Frog   916 SGHPSEKEIKAQQDKLNTRWSQFRELVDKTKDALSSALSIQNYHLECNETKSWIREKTKVIESTQ 980

  Fly   285 DYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSL 349
            :.|.|||.|.|||||..|:||||||:|.|::.|..||::|.:.|.|.:..|.|:.|||.|.|:.:
 Frog   981 ELGNDLAGVMALQRKLTGMERDLAAIEAKLTDLQKEAEKLEAEHPDQAQAIMDRLAEINNVWEEM 1045

  Fly   350 TTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEID 414
            .|..:.|::.|.|:..|.:||.|..|..||::..:..|:::::...:|.||.||.:|:..|.||:
 Frog  1046 KTTLKNREESLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLAEAEKLLTQHENIKNEIN 1110

  Fly   415 AREDSFKLTTESGQKLLEREHYAA-AEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRD 478
            ..|:.::...:.|:.:.:.:..|. ..::::|.||:...:.|..:||:|:.|..|....|||.||
 Frog  1111 NYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQSLLSQSHAYQLFLRD 1175

  Fly   479 TEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYA 543
            |:||:.::..||..||:.:|.::|::.||.||..|||..::.|.||||.|:.....:|::.::..
 Frog  1176 TKQAEAFLNNQEYVLAHTELPNNLEAAEAAIKTQEDFMTTMDASEEKINAVVDTGRRLVNDENIN 1240

  Fly   544 ADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPT 608
            :|.:.::...:.:|....:..::.....|:|:...|:|.:||.|...||:||:..|.|.||.:..
 Frog  1241 SDKIEEKVDSIDSRHKKNRAGANDLLMRLKDNREMQKFLQDCQELSLWINEKMLTARDMSYDEAR 1305

  Fly   609 NLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKK 673
            ||:.|..|||.|..||.:||..::.|...|.:||.::......:..:|..:..:||.|...:..|
 Frog  1306 NLHSKWLKHQAFMAELASNKEWLDKIEKEGNQLIAEKPETEAIVKEKMSALHAMWEELESTTQTK 1370

  Fly   674 GTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIE 738
            ..:|.:|.:.:.|.::..|::.||..:|.|:.|:|:|||||||..|.||..:||..:...:..:|
 Frog  1371 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMDVRKKEVE 1435

  Fly   739 SIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWI 803
            .::..|....:.|. ..|.:..:...:..|:..|.||:.|||::||.|.::.|..||:|||..|:
 Frog  1436 ELRSQAQALSQEGK-STDEVDGQRQVVEVRFIELLAPLNERKKYLLASKEIHQFNRDVEDEILWV 1499

  Fly   804 REKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRL 868
            .|:.|:|.||:.|.:|..||.|:||:|.:..||..|:.|..::....:.:|.|....::.|.|||
 Frog  1500 EERMPLATSTDHGHNLQTVQLLMKKNQTLQKEIQGHQHRNDDIFERSKMILDDSSLNAEAITQRL 1564

  Fly   869 EALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLK 933
            ..||..|:.|.|::.:|.:.|::|.:|.||:.|..|||:||.|:|......:..|||.|:.::||
 Frog  1565 ADLQALWSLLIEETEKRHRRLEESHRAQQYYFDGAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1629

  Fly   934 KHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLT 998
            ||:.|...:|.:..|:..|.:.::                .:||     |..|            
 Frog  1630 KHQILEQAVEDYAETVHQLSKTSR----------------ALVA-----EGHP------------ 1661

  Fly   999 LLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALAR 1063
                                                     ::..|:.||:|::..|..|..|:.
 Frog  1662 -----------------------------------------ESERISMRQSQVDKLYAGLKDLSE 1685

  Fly  1064 ERQNKLNETVKAYVLVREAADLAQWIRDKE----NHAQIADVVGEDLEEVEVLQKKFDDF-NDDL 1123
            ||:.||:|..:.:.|.||..||.|||.::|    :|.     :|:|.|.|.:||::|.:| .|..
 Frog  1686 ERRGKLDERQRLFQLNREVDDLEQWIAEREVVAGSHE-----LGQDYEHVTMLQERFREFARDTG 1745

  Fly  1124 KANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHR 1188
            ...:.|:.::|.:|..|.:.|.::|| .|......|||.|.:|..|...:...|.::.|:.:|:.
 Frog  1746 HIGQERVDSVNHMADDLINSGHSDAA-TIAEWKDGLNEAWADLLELIDTRTQILAASFELHKFYH 1809

  Fly  1189 DIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHP- 1252
            |..|....|.:|...| .::||:|..:|:||||.|...|.|:.||..::|||.|.|.||..::. 
 Frog  1810 DAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAG 1873

  Fly  1253 DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELAN 1317
            |.|:....::.|:.|.|..::.....|:.:|:|:.|..||.|..|||:.|:..::..:.:.|...
 Frog  1874 DKADDIQKRESEVLEAWKALLDACDGRRLRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPR 1938

  Fly  1318 DVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFG 1382
            ||:..|.|:..||..:|                                |||||..:|....:.|
 Frog  1939 DVSSVELLMNNHQGIKA--------------------------------EIDARNDSFTTCIELG 1971

  Fly  1383 NELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAF 1447
            ..||...||||.|||||:..|.:.|:::...|.:|...|...|::..:.||..:||:|:..:|.:
 Frog  1972 KSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLFGQEPY 2036

  Fly  1448 LNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVL-- 1510
            |::.:...:...||.|||:||.|:|:....:::.:||:.:....:.:........:.|||...  
 Frog  2037 LSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRLQEEEERKRKPPTPE 2101

  Fly  1511 -----------ERWRHLKEGLIEKRSRLGDEQTLQQFSRDAD--EIENWIAEKLQLATEES---- 1558
                       ::|...|||....::.|..:|...:.:.:||  |:.|...|:...:.|.|    
 Frog  2102 LSPKLSEDGSPQQWDGTKEGEQISQNGLPSDQESPRMAENADTNELVNGSTEQRSSSKESSPIPS 2166

  Fly  1559 ----YKDPANIQSK---------------------HQKHQAFEAELAANADR----IQSVL---A 1591
                .|..:.:|.:                     |:||: :|......:.|    :..|:   .
 Frog  2167 PTADRKSKSGMQPQTAATLPAKTQEMPSAQFEGFLHRKHE-WEGHNKKASSRSWHNVYCVINNQE 2230

  Fly  1592 MGGNLIDKKQCSG------SEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKD- 1649
            ||.....|...||      ....:::.:.::|..::...|..   .|||.:.|:   |:...|| 
 Frog  2231 MGFYKDSKNAASGIAYHNEIPANLKEAVCEVATDYKKKKHVF---KLKLNDGNE---YLFQAKDD 2289

  Fly  1650 --LDFWLGEVESLLTTEDSGKDLAS--------VQNLMKKHQLVEADIVAHEDRIKD 1696
              ::.|:..:.:.:|::.:...|::        .|.|.....:.::.....:|:.||
 Frog  2290 EEMNTWIQAITNAITSDKTEVSLSTQSTPASSRAQTLPASVTVTDSPGKREKDKEKD 2346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 4/51 (8%)
SPEC 1074..1287 CDD:238103 69/218 (32%)
SPEC 1182..1425 CDD:238103 74/243 (30%)
SPEC 1426..1638 CDD:238103 52/268 (19%)
SPEC 1533..1744 CDD:238103 37/219 (17%)
SPEC 1646..1850 CDD:238103 10/62 (16%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 70/315 (22%)
SPEC 154..364 CDD:238103 76/210 (36%)
SPEC 261..470 CDD:238103 74/210 (35%)
SPEC 471..680 CDD:238103 66/208 (32%)
SPEC 682..893 CDD:238103 71/210 (34%)
Spectrin 893..>961 CDD:395348 23/67 (34%)
sptbn1NP_001362280.1 SAC6 46..>452 CDD:227401
Spectrin 420..523 CDD:334073
SPEC 528..740 CDD:238103 47/148 (32%)
SPEC 640..847 CDD:238103 38/206 (18%)
SPEC 745..953 CDD:238103 33/207 (16%)
SPEC 956..1167 CDD:238103 74/210 (35%)
SPEC 1169..1378 CDD:238103 66/208 (32%)
SPEC 1379..1589 CDD:238103 71/210 (34%)
SPEC 1590..1801 CDD:238103 73/290 (25%)
SPEC 1803..2024 CDD:238103 77/253 (30%)
SPEC 2017..>2072 CDD:197544 16/54 (30%)
PH_beta_spectrin 2197..2302 CDD:269975 21/111 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

Return to query results.
Submit another query.