DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sptbn4a

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_001342754.3 Gene:sptbn4a / 100003123 ZFINID:ZDB-GENE-060531-133 Length:1409 Species:Danio rerio


Alignment Length:1508 Identity:313/1508 - (20%)
Similarity:568/1508 - (37%) Gaps:417/1508 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   599 ATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLW 663
            |.|.:..:...|:.|..|||.|..||..||..:..|...|.|||::|......:..:::||...|
Zfish     4 ARDGARDEAQKLHRKWMKHQAFMAELARNKEWLAKIEQEGEELIQEQPELRSVVEMKLKEIRECW 68

  Fly   664 ETLVQASDKKGTKLNEACQQQQFNRT-------IEDIELWLSEIEGQ--LLSEDHGKDLTSV--- 716
            ..|...:..|..:|.|.    |.:||       :.|::..|:.|:.|  .|...|....|.:   
Zfish    69 SHLENTTKVKARQLFE
T----QNHRTTDLPTNNLSDLDQHLNIIQEQPPTLGSTHTTQPTLLQPR 129

  Fly   717 ----QNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGN-----LSARYAAL 772
                |.||:        :.:.:|:::.....:.....:.|      |..||.     ...|...|
Zfish   130 PTFSQQLQR--------IQSWEDQMQLFHGVSEVMAGAEH------RRPEGEEQGGVPETRIVRL 180

  Fly   773 AAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEIN 837
            ..|:.||::.||.|.::.|:.:|||||..||:|:..:|:|...|.:|..||||:|.|:|:..|:.
Zfish   181 IEPLKERRRILLASKELHQVTQDLEDEIIWIQERLHLASSIEYGTNLQSVQNLMKNHEALQMEMQ 245

  Fly   838 NHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADA 902
            ..:.||..|:...|.:...:....:.:|:....:::.|..|:.:..:|...||...||.||::.|
Zfish   246 VRKGRLEEVLERAEAVAALRTPEVELVREGAGHVRQLWEVLQVEMERRTVMLDAVNQAQQYYSQA 310

  Fly   903 NEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVV 967
            .:.|||:..::......:.|.||.|:..|||:..||...:|.:..|:.:|.:|   ||       
Zfish   311 AKTESWLSGQKLQVLNEEKGNDEASTLRLLKEQLALEQTVENYAETVGSLSQQ---CR------- 365

  Fly   968 DITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLS 1032
                                                                     :.::.|..
Zfish   366 ---------------------------------------------------------RMLELGHP 373

  Fly  1033 ASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQ 1097
            .|:|       |.|:|..|:..|.:|..|..:|:.||.:....|.|.||...|.:||.::|..|.
Zfish   374 DSEQ-------ITKQQAHIDRLYVSLKDLVEQRKTKLEQQYWLYQLKREVEALEKWISEREAVAS 431

  Fly  1098 IADVVGEDLEEVEVLQKKFDDFNDDLKA-NEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNE 1161
            ..: :|:|||.|.|||..|..|:.:.:| .:.::.::|::..::.....::|| .|......|||
Zfish   432 STE-LGQDLEHVTVLQSSFTQFSSETRAVGQKQMDSVNKMVNEMIDCSHSDAA-TIAEWKDGLNE 494

  Fly  1162 KWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQ-------TL 1219
            .|.:|..|...:|..|.:::::.:|..|..|....|..|...|      .::||.|       ||
Zfish   495 SWADLLELMETRAQMLAASYQLHKFFTDCQEVLVQIEGKMRQL------PEVRSCQVSSANPGTL 553

  Fly  1220 QRKHEGVERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKL 1283
            ||.....|..|..|..::|||.|.|.:|...:. :.|:...::::|:.:.|.:::......:.::
Zfish   554 QRLLHSFEHSLQLLVSQVRQLQENAVQLRAIYAGEKADAILSREQEVMQAWKELLVACEGSRVQV 618

  Fly  1284 LDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGA 1348
            ....|..:|.:..|:|..|::.:|..:..::.|.|::..|.::.:||                  
Zfish   619 TTVTDKIQFFAVVRELSMWMDGIMGQIGPNDDARDLSVLEGMMSQHQ------------------ 665

  Fly  1349 AASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKA 1413
                          ..:::::.::..|....:.|..||.|.:.|:.|:|||:|.:...::::.:.
Zfish   666 --------------NLKSKMENKSKNFVHCVEMGKMLLAARNPAAEEVKEKLEYVMAKQKEMNER 716

  Fly  1414 WT---ERRLQLEQNL-DLQLYMRDCELAESWMSAREAFLNADDDANAG-GNVEALIKKHEDFDKA 1473
            |.   |:..|.:|.| ..|..:.:    :.|::.:|.......:|..| ..||.||::||.|.||
Zfish   717 WDLHWEKLQQAKQRLQSTQTGLTE----QPWLTIKEPITPITREAGGGTDEVEELIRRHEAFRKA 777

  Fly  1474 INGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLER-------------------------- 1512
            .:                ..::|::|....||.|:.|.:                          
Zfish   778 AS----------------TWKDHFSSLRQAEKMKEELNKPPSTSSLLSRQMFPLSCLVPSSSSSS 826

  Fly  1513 -----WRH-LKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKL------------QLATEESY 1559
                 :|: |::.|:|  |:.|.:.        ...||:.:...|            .:....||
Zfish   827 SSSSLFRNPLQDSLLE--SKPGPDH--------MHSIEHTVTHTLPQRLGSSLNPYTPVMNGSSY 881

  Fly  1560 ---KDPANIQSKHQKHQAFEAELAANADRI------QSVLAMGGNLIDKKQCSGSEDAV--QKRL 1613
               :.|:.:.::...:|:.:.:..::.|..      |.|...|||       |.|...:  |..|
Zfish   882 HGLQQPSGVVNESPLYQSIKQQGVSSLDNSSYQGLNQQVGVFGGN-------SSSYTGLNQQGAL 939

  Fly  1614 TQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMK 1678
            .:....:..|.|                  :.||       |.||               ..:..
Zfish   940 AEDGSSYHSLNH------------------LGAV-------GVVE---------------PKIGY 964

  Fly  1679 KHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTA-----------GIQEKRQSINERYER---- 1728
            ..|.::||  ..:.:|..::.....|:|:.:...|           |:....:.|:.|.:|    
Zfish   965 AWQHLKAD--CFQPKINHIHKAVSPLLEAHRAQLASAGANMPAPPVGMDPSLEMIHSRLQRDPRG 1027

  Fly  1729 ------ICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGR----------DLT 1777
                  :.:|...|:.||....:..|      :.::.:.|..|:|..:.|.|          :.:
Zfish  1028 SRSDPQMDHLRREREYRLGRQTSSEQ------EIQARLNELPLIVRQERYRRRMERQSSSEQEAS 1086

  Fly  1778 GVQNLKKKHKRLEAELGSHEPA---------------IQAVQE------AGEKLMDVSNLGVP-- 1819
            |.|.: :||...:||.|. ||:               ::.|||      .||.....|:|..|  
Zfish  1087 GKQRV-QKHDSSDAESGK-EPSDKKPSGEKRSTMAEIVEQVQEREACHARGEVYRPASSLSAPVS 1149

  Fly  1820 --------------------EIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEE- 1863
                                |.|:..::.:   |..:::.:| .|....::.::.||.:..||| 
Zfish  1150 RLDRPRARDRPKPRRRPRPKEPEEPRRSRS---APAQSVPST-PQPPTHTVHHEGFLYRKHEEEG 1210

  Fly  1864 --------AWIT------------EKQQLLSVEDYGD---------SMAAVQGLLKKHDAFETDF 1899
                    :|:.            .|....:...|.|         ......|..||.:.|....
Zfish  1211 KERSPNSKSWVNLFCVLKQGEIGFYKDARHTTTPYNDEPLLNLAICEFDTTNGYKKKKNVFILRT 1275

  Fly  1900 TAHKDRCSLICDQ 1912
            ||..|...|..|:
Zfish  1276 TAEGDYIFLAKDE 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 57/221 (26%)
SPEC 1182..1425 CDD:238103 51/253 (20%)
SPEC 1426..1638 CDD:238103 45/267 (17%)
SPEC 1533..1744 CDD:238103 39/254 (15%)
SPEC 1646..1850 CDD:238103 48/277 (17%)
SPEC 1852..2062 CDD:238103 18/91 (20%)
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103 24/80 (30%)
SPEC 682..893 CDD:238103 57/231 (25%)
Spectrin 893..>961 CDD:395348 22/67 (33%)
sptbn4aXP_001342754.3 Spectrin <1..84 CDD:278843 24/79 (30%)
COG5281 <134..>509 CDD:227606 114/464 (25%)
SPEC 196..407 CDD:238103 67/284 (24%)
SPEC 302..514 CDD:238103 68/287 (24%)
SPEC 515..727 CDD:238103 49/249 (20%)
PH 1196..1303 CDD:278594 18/93 (19%)
PH-like 1198..1301 CDD:302622 18/91 (20%)
PRP38_assoc 1322..1403 CDD:289628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.920

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