DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pol31 and POLD2

DIOPT Version :9

Sequence 1:	NP_647659.1	Gene:	Pol31 / 38228	FlyBaseID:	FBgn0027903	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001120690.1	Gene:	POLD2 / 5425	HGNCID:	9176	Length:	469	Species:	Homo sapiens

Alignment Length:	432	Identity:	186/432 - (43%)
Similarity:	259/432 - (59%)	Gaps:	23/432 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDVHCILI 73
            |.|.|..|||....:.:|:.|:||.||.:|...|...||:.||:...:||||||:.|:  .|.::
Human    32 YTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFLENRAQQHWGSGVGVKKLCELQPEE--KCCVV 94

  Fly    74 GTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLATGVVC 138
            ||:||....:|||||::|||:.|.|||||..|..|:|::||||||||::|:|.::...|.||.|.
Human    95 GTLFKAMPLQPSILREVSEEHNLLPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVL 159

  Fly   139 AALGGTDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGL--------DQLQAHKFVEALNL 195
            |..|....||.|.|||..|.:..||||..|:...|.::|.|||        ..|.....|:.
Human   160 AVFGSVRDDGKFLVEDYCFADLAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDV--- 221

  Fly   196 FQYWLAGSLGNNKE---AGSMVRLIVAGNSVRASAMAHVPTLQVAR--TQANANDTVQAVSQLDQ 255
                :.|.||:..|   |..:.|:|:|||.:..|..:. .::..|:  |:.....:|:||..||:
Human   222 ----VTGQLGDEGEQCSAAHVSRVILAGNLLSHSTQSR-DSINKAKYLTKKTQAASVEAVKMLDE 281

  Fly   256 WFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVVGTSG 320
            .....:.|:|||:|||.:||.|:.|||||.|.||||.|...:|.|.|||||...:|....:||||
Human   282 ILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSG 346

  Fly   321 QNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNCESFA 385
            |||||:.|.:|::..||.|..||...|::|||||||.|||:.::||||..||||||:.||..||.
Human   347 QNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFG 411

  Fly   386 TELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFS 427
            :::..|.|.:...||.||.||.||:..:|:|.:|.|:.::||
Human   412 SKIIRGPEDQTVLLVTVPDFSATQTACLVNLRSLACQPISFS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pol31	NP_647659.1	MPP_PolD2_C	175..426	CDD:277333	108/263 (41%)
POLD2	NP_001120690.1	DNA_pol_D_N	49..176	CDD:407857	62/128 (48%)
POLD2	NP_001120690.1	MPP_PolD2_C	215..452	CDD:277333	103/244 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156708
Domainoid	1	1.000	175	1.000	Domainoid score	I3668
eggNOG	1	0.900	-	-		E1_COG1311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4538
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2300
Isobase	1	0.950	-	0	Normalized mean entropy	S1954
OMA	1	1.010	-	-		QHG54495
OrthoDB	1	1.010	-	-		D322719at33208
OrthoFinder	1	1.000	-	-		FOG0005088
OrthoInspector	1	1.000	-	-		oto89284
orthoMCL	1	0.900	-	-		OOG6_102286
Panther	1	1.100	-	-	LDO	PTHR10416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R344
SonicParanoid	1	1.000	-	-		X3610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750