Protein Alignment PolD2 and POLD2

DIOPT Version :10

• Sequence 1: NP_647659.1
• Gene: PolD2 / 38228
• FlyBaseID: FBgn0027903
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: XP_047276453.1
• Gene: POLD2 / 5425
• HGNCID: 9176
• Length: 687
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 186/432 - (43%)
• Similarity: 259/432 - (59%)
• Gaps: 23/432 - (5%)

  Fly     9 YENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDVHCILI 73
            |.|.|..|||....:.:|:.|:||.||.:|...|...||:.||:...:||||||:.|:  .|.::
Human   250 YTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFLENRAQQHWGSGVGVKKLCELQPEE--KCCVV 312

  Fly    74 GTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLATGVVC 138
            ||:||....:|||||::|||:.|.|||||..|..|:|::||||||||::|:|.::...|.||.|.
Human   313 GTLFKAMPLQPSILREVSEEHNLLPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVL 377

  Fly   139 AALGGTDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGL--------DQLQAHKFVEALNL 195
            |..|....||.|.|||..|.:..||||..|:...|.::|.|||        ..|.....|:.
Human   378 AVFGSVRDDGKFLVEDYCFADLAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDV--- 439

  Fly   196 FQYWLAGSLGNNKE---AGSMVRLIVAGNSVRASAMAHVPTLQVAR--TQANANDTVQAVSQLDQ 255
                :.|.||:..|   |..:.|:|:|||.:..|..:. .::..|:  |:.....:|:||..||:
Human   440 ----VTGQLGDEGEQCSAAHVSRVILAGNLLSHSTQSR-DSINKAKYLTKKTQAASVEAVKMLDE 499

  Fly   256 WFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVVGTSG 320
            .....:.|:|||:|||.:||.|:.|||||.|.||||.|...:|.|.|||||...:|....:||||
Human   500 ILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSG 564

  Fly   321 QNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNCESFA 385
            |||||:.|.:|::..||.|..||...|::|||||||.|||:.::||||..||||||:.||..||.
Human   565 QNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFG 629

  Fly   386 TELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFS 427
            :::..|.|.:...||.||.||.||:..:|:|.:|.|:.::||
Human   630 SKIIRGPEDQTVLLVTVPDFSATQTACLVNLRSLACQPISFS 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD2	NP_647659.1	DNA_pol_D_N	26..155	CDD:436215	62/128 (48%)
		MPP_PolD2_C	175..426	CDD:277333	108/263 (41%)
POLD2	XP_047276453.1	DNA_pol_D_N	267..394	CDD:436215	62/128 (48%)
		MPP_PolD2_C	433..670	CDD:277333	103/244 (42%)