DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pol31 and pold2

DIOPT Version :9

Sequence 1:	NP_647659.1	Gene:	Pol31 / 38228	FlyBaseID:	FBgn0027903	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001005794.1	Gene:	pold2 / 448271	XenbaseID:	XB-GENE-999387	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	185/436 - (42%)
Similarity:	259/436 - (59%)	Gaps:	27/436 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TKYENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDVHCI 71
            |:|.|.||:|||....:.:|:.|:||.||.:|..||...|::.||:...::|||||:||:  .|.
Frog    30 TQYANCSSVFRLGERTFTRQYAHIYATRLEQMRPLLIKRAKQLWGDDVAVRKLCELQGEE--KCC 92

  Fly    72 LIGTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLATGV 136
            ::||:||....:|||||:||||:.|.|||.|..|....|:::|||||||::|:|..:.|.|.||.
Frog    93 VVGTLFKSMELQPSILREISEEHNLLPQPARHKYISDSDELILEDELQRIKLEGATDVQQLVTGA 157

  Fly   137 VCAALGGTDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGL-------DQLQAHKFVEALN 194
            |.|.||.....|.|.|||........|.||..:...|.::|.|||       |.|.      .|.
Frog   158 VLAVLGSEGDAGKFMVEDFCLTSLPAQSPLPRLSEDRFVLLTSGLGLGGGSGDSLM------GLQ 216

  Fly   195 LFQYWLAGSLGNNKEAGSMVRL---IVAGNSVRASAMAHVPTLQVA-----RTQANANDTVQAVS 251
            |....:.|..|..::.|...|:   |:|||.:..:.... .:|..|     :|||   .:|:||.
Frog   217 LLLDLVTGQAGAEEDQGCAARISRVILAGNLLSQNTQGK-DSLNKAKYLSKKTQA---ASVEAVK 277

  Fly   252 QLDQWFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVV 316
            .||:.....:.|:.||:|||.:||.|::|||||.|:|||||:|..:|.|.|||||...:|....:
Frog   278 MLDEILLQLSGSVSVDVMPGAFDPTNYILPQQPLHRCMFPQSAVYSTLQLVTNPYEAEIDGVRFL 342

  Fly   317 GTSGQNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNC 381
            ||||||:||:.:.:|:...|:.|..||..||:.|||||||.|||:.:||||||:.|||||:.|:.
Frog   343 GTSGQNISDIYKYSSMQDYLDILEWTLQVGHLCPTAPDTLGCYPFYKSDPFILQNCPHVYFCGSA 407

  Fly   382 ESFATELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFS 427
            ..|:.:...|.||:|..|:.||.|..||:..:|:|.||.|:.|:||
Frog   408 PKFSCKEVTGKEGQRVLLLTVPEFCSTQTACLVNLRTLQCQPVSFS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pol31	NP_647659.1	MPP_PolD2_C	175..426	CDD:277333	109/265 (41%)
pold2	NP_001005794.1	DNA_pol_D_N	49..176	CDD:375491	61/128 (48%)
pold2	NP_001005794.1	MPP_PolD2_C	222..452	CDD:277333	101/233 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3763
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4538
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2313
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322719at33208
OrthoFinder	1	1.000	-	-		FOG0005088
OrthoInspector	1	1.000	-	-		oto103117
Panther	1	1.100	-	-	LDO	PTHR10416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160