DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pol31 and AgaP_AGAP008910

DIOPT Version :9

Sequence 1:	NP_647659.1	Gene:	Pol31 / 38228	FlyBaseID:	FBgn0027903	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	XP_319657.4	Gene:	AgaP_AGAP008910 / 1279877	VectorBaseID:	AGAP008910	Length:	458	Species:	Anopheles gambiae

Alignment Length:	433	Identity:	220/433 - (50%)
Similarity:	298/433 - (68%)	Gaps:	10/433 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLETKYENLSSIFRLKGHDYQKQFFHLYAHRLAEMTRLLTPLAQKKWGNKEPIKKLCELRGEQDV 68
            ||:..|...|..:.....|:.|||..:||.||.||.:||....|||||.:.|||:|.:||.:...
Mosquito    21 RLKVPYTYRSECYHFAKKDFSKQFAFIYASRLEEMLKLLEDSVQKKWGTEMPIKRLADLREDCPH 85

  Fly    69 HCILIGTIFKHQAHKPSILRDISEENQLAPQPPRQNYSDPEDKIVLEDELQRVRLQGKLNGQLLA 133
            .|::|||:||||..||||||:|||||||||||||.:|::..|.::|||.|||::|.||::...:.
Mosquito    86 KCVIIGTLFKHQELKPSILREISEENQLAPQPPRSHYTNDNDILILEDALQRIKLVGKIDVHSIV 150

  Fly   134 TGVVCAALGG---TDSDGFFNVEDILFYESGPQKPLAPIKRSRLLVLASGLDQLQAHKFVEALNL 195
            ||||||.:|.   .:|||.|.|||.:||:...||.|.|::.|.||||.|||::..|:.|...|.|
Mosquito   151 TGVVCAVMGKFWYEESDGRFFVEDYIFYQGALQKELPPLQTSPLLVLISGLNESAANDFSTPLEL 215

  Fly   196 FQYWLAGSL-----GNNKEAGSMVRLIVAGNSVRASAMAHVPTLQVARTQANANDTVQAVSQLDQ 255
            .|.|:.|:|     |::.||.|:||:::|||||:||............|:.:|  .:.||..:|.
Mosquito   216 LQQWVFGNLEGLLDGHDWEAASIVRIVIAGNSVKASPKPKNHHSSKVTTETDA--LLGAVKTVDS 278

  Fly   256 WFASWARSLPVDIMPGPYDPANFMLPQQPFHKCMFPQAAQLATFQAVTNPYSCRLDEALVVGTSG 320
            ...:.|:|:|:|:|||.:||||.||||||.|.|:||::...|:|:.|.|||:..|.:..||||||
Mosquito   279 LIHNLAQSVPIDLMPGEFDPANHMLPQQPMHHCLFPRSKGFASFRGVPNPYAFDLADRYVVGTSG 343

  Fly   321 QNVSDLLRSTSLDSALEALRCTLTWGHVAPTAPDTLACYPYIESDPFILRECPHVYYAGNCESFA 385
            |||.|::|.:.::|.||||:.||.|||:.|||||||.||||.|.||||:.||||||:|||...|:
Mosquito   344 QNVLDVMRYSKIESPLEALKATLRWGHLIPTAPDTLPCYPYYEKDPFIIGECPHVYFAGNVGEFS 408

  Fly   386 TELHEGSEGKRTRLVCVPSFSKTQSVAVVDLDTLDCRMVNFSV 428
            ||:..|:.|::|||||||||:.:||||||:|.|::||.|:|.|
Mosquito   409 TEMWTGAGGQQTRLVCVPSFADSQSVAVVNLRTMECRKVSFKV 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pol31	NP_647659.1	MPP_PolD2_C	175..426	CDD:277333	131/255 (51%)
AgaP_AGAP008910	XP_319657.4	HYS2	37..449	CDD:224230	214/413 (52%)
AgaP_AGAP008910	XP_319657.4	MPP_PolD2_C	195..449	CDD:277333	131/255 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	213	1.000	Domainoid score	I5971
eggNOG	1	0.900	-	-		E1_COG1311
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4538
Inparanoid	1	1.050	440	1.000	Inparanoid score	I3560
OMA	1	1.010	-	-		QHG54495
OrthoDB	1	1.010	-	-		D322719at33208
OrthoFinder	1	1.000	-	-		FOG0005088
OrthoInspector	1	1.000	-	-		oto107276
Panther	1	1.100	-	-	LDO	PTHR10416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3610
TreeFam	1	0.960	-	-
	13	12.940