DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhc62B and dhc-4

DIOPT Version :9

Sequence 1:NP_995958.2 Gene:Dhc62B / 38226 FlyBaseID:FBgn0013811 Length:3964 Species:Drosophila melanogaster
Sequence 2:NP_001338793.1 Gene:dhc-4 / 189209 WormBaseID:WBGene00012272 Length:2727 Species:Caenorhabditis elegans


Alignment Length:3394 Identity:623/3394 - (18%)
Similarity:1135/3394 - (33%) Gaps:992/3394 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 ERRHYQFLKQKAADVKVRVARQQ-WQPEPDMRLLPQSHYEDNLRREVRKIVVPPMLRRTEAKILS 102
            |:.|::..|........||..|: |.         |..|||.||||.|||   |.:.|.:.....
 Worm     6 EKEHFKLRKHTRYLTIHRVVEQKSWH---------QLAYEDRLRRESRKI---PKICRKQFLKWH 58

  Fly   103 FASERLKNKYPELVQAYMHDVHEEFNRLMKVYSMK----NILRHPEFSDEDPAQFELPRPDIGFR 163
            ...:..|.|:..|         .|.||...:|..|    .:.:||          ..||.:..|:
 Worm    59 VEQQEAKKKFRRL---------REKNRDESIYVAKLWYYVLKKHP----------LKPRVEWSFQ 104

  Fly   164 RPGRTQNYSNFLENRRRIAQKLLILQLPLRAILNISVGELPKLACIFNYVL----ATGAMQQQLG 224
            |..:..      ....||||:|..|                 :.|...|.|    |.|       
 Worm   105 RVHKLS------PKNERIAQELEEL-----------------MDCAERYALIENVADG------- 139

  Fly   225 LGGREALSYKFYHKYIQNQLDKVNTFLRWTWYPKIVQVLRKLMRKRVMPMSTWKRSWNAMEALM- 288
                       |.|.::::|.::|...::..:.|                       |..|.|: 
 Worm   140 -----------YQKRVKDELARLNKIEKYHHHVK-----------------------NNREILLR 170

  Fly   289 NREMTNMKIRTFEEMYRMCSHPRTMPMMRMSLEWSEFSSDLDTRPNAWSI-LRTFAEI------- 345
            ::.:..||||.|.|             .|..|.: |.:..:|  |...:| ::.|.|:       
 Worm   171 SQSLAAMKIRIFFE-------------NRKGLIF-EVNELID--PEVGNIPIKKFREVTLTKVLE 219

  Fly   346 -ATEISM----VGYRMEPLQPQVQTL----TSMAAYAKVNDYLKIEMN-------DNFLKD---- 390
             :.||:|    ..:|.|..:..||..    |:.||:..:..|||...|       |..:.|    
 Worm   220 FSQEINMKLLKKNWRDEKKRNIVQNCIVQETTNAAFGTIQAYLKTLRNKPAFLSIDCMIVDRKLW 284

  Fly   391 VIDKVQNIILRTYQEVIQYVEGFRDKYYALYSWQER-----DALNQFLSEPHEF-EEYFARIDMY 449
            |..:...::|:....|:..:|..|.......:|||.     :.|:..|...|.| :.|...||.|
 Worm   285 VNSEQIRLLLKEPISVMCALENVRMSTEDCETWQEEAMICVEVLSHELIVHHPFIQPYAFLIDDY 349

  Fly   450 YGFIQMLRSEPATEYFVMAVIHNEPAIFGLR-TLAENLIHEITTIIIR-EHIKAEVD-------- 504
                   :..|......:..::::.....:| |.|..|: .|...::| |.:.:|||        
 Worm   350 -------KVSPKLTEEELIKMYDDSTHLQIRLTKAVKLL-TIRCFVLRLESVWSEVDRRIRSFRN 406

  Fly   505 ----------------ICDEFEK----IKYRALEIPKSTEELLESAEYMIHVKKDKIAELTDRIQ 549
                            :..:|.|    ::||::: |..........:.|:.      .|:.|.::
 Worm   407 QLKMAIRRKFTTLLNKLLHDFRKYDRALQYRSID-PSMMLSNKAQVDLMLQ------NEIGDSVR 464

  Fly   550 YCLQVGTNIVELTEMSKYHFDLTIKTINWIKDINDI------C--DYNASQQEQFKFTFEEHLQE 606
            ..::|...:.|:|:    |..|....::.:..:..:      |  |:....|::.. ||...:.:
 Worm   465 QFVEVYDKVFEITQ----HISLDTSQLDTLLQLASLRLSLPQCINDHAHFFQKRIS-TFLHFVTK 524

  Fly   607 VIKKLNSDIDELLPKLTVIDDMSRPDKFRDSYI--------ILQNFIDQLKTFDDYVAWINKEEK 663
            ...|:.|::.:.:.||.::..|..|.:. |:|:        :|.|.|.:::.       :||.|.
 Worm   525 KQSKVMSNVQKAMEKLKIVQTMGNPQEV-DNYLTQMAKLRPMLDNLITEIED-------LNKFET 581

  Fly   664 LFKVALTEYPKLDIIKTFVYPFAELMKCCIEWQRYLSVWNDGPFEYLEPQFVERTTDDYLKE--- 725
            ...:.:::..|:   :.||.....|                        |.:...|..|.|.   
 Worm   582 AVDIQVSDVTKM---RHFVGEIGSL------------------------QSLFEATSGYYKHVNA 619

  Fly   726 -FQKNQKYYRVKIKQDLIDN---PVCKFKGQTEDPDPAKHPVPLRLCTSMIQSIKDFTTGVFIVN 786
             |:..:....:...::.||.   .:..|:........|||.:....     ..:..|.....:..
 Worm   620 FFESRRTLVNIDASRNFIDQFTIQLSIFESSLTTHRAAKHFIAYAR-----NEVDAFKKNFAVAE 679

  Fly   787 TMCNPALRKRHWKEMSEIAGFDVTPDAGTTLRKILNSGLDPILDQFEIISIGANKELQLWNALQA 851
            .|....|...||..||||.|||:||.|.:::.:|...||:..|.|.:.|:..|.:|....:.|.|
 Worm   680 VMSCRRLLDAHWLRMSEIVGFDLTPYANSSIAQICELGLEAHLQQLKPIAFSAEREATAADQLHA 744

  Fly   852 MIKEWETRVFPYGPYKETGVQILSSLDDIQALLDDHI--LKTLVMRGSAFMKPCEEEVRAWYEKI 914
            ::..|.........|.:..:.:...|.::...:.:.|  ||.:    :...:..::.:..|.|..
 Worm   745 IVTFWSQEPLEMRCYVQWKLSLALKLSELHHRVQNDINTLKHM----TNVEQITDDSLPQWIEWT 805

  Fly   915 MRVNETLDQWGKVQANYLYLLPIFSSKDIVAQMPEE-----GRLFVIVEQTYTRNMGLVLRQPLV 974
            .|..:.|..|.:.|..::.:..||.:.....|...|     .:.|:.:|    ||   ||:...:
 Worm   806 ARAEKILKAWCETQQKWMRVANIFVTCRDTLQKEYELLRTCAKYFIKIE----RN---VLKDETI 863

  Fly   975 METAPVSGLLESLQKANELLEDIATGVSNYLEKKRLYFPRFFFLANDEMLEILSETKDPLRVLPH 1039
            .....:..|...:||.|.::..|..||...|:..|:...|....:...:|.:.|.|....|:...
 Worm   864 YRVMQLPHLPCWIQKINSMVSIIIQGVRGLLDGMRMNNARLCLSSEVHLLNLFSTTSIETRLKLL 928

  Fly  1040 LSKCFEGINSLEFDAAKNVLAMIS--SDKETIEFIEQVSTAAAGGSVEKWLIGVEDEMLKAVRYQ 1102
            |..||..:..|.|: .:|.|.|:.  .:|.|::..:.                            
 Worm   929 LKDCFPSLRRLCFN-RRNQLEMVDLLEEKVTVDLTKS---------------------------- 964

  Fly  1103 NELSFAHYPKVKRHEWVLEWPQMTVLAISQVYWASRVHGCLRRTFGGNMTIMMNFFQELSKELND 1167
                     :::..|     |...:.:|.|.:                           :.:|.|
 Worm   965 ---------EIESQE-----PCELIRSIEQAF---------------------------ASKLTD 988

  Fly  1168 IVTLVRSPKISNLNRI--TIKSLIVIDVHAKDVSEDLIKNKVSSEFDFQWLA-QMRYYWEDDKTW 1229
            |:|..|..:....:|:  .:..||    ..:...:.|..::|...:..|..: |.:.....|..:
 Worm   989 IITYERQDRSKAASRVGANVAELI----ETRQTLDPLFLSRVEKTYYIQHRSVQRQSLLTVDFVY 1049

  Fly  1230 VRIINATVPFANEYLGNSDRLVITPLTDRCYRTLVGAYQLHLNGAPEGPAGTGKTETTKD----L 1290
            ...||..:|.:.....:|..:|:.                           .|:..:|:.    |
 Worm  1050 STEINRFIPRSLADSWSSGHIVLL---------------------------IGEMCSTRSFVLRL 1087

  Fly  1291 AKALAVQCKVFNCSDGLDYKAMGKFFKGLASCGAWACFDEFNRIELEVLSVVAQQILLIIQAVRS 1355
            |..:....::.|....|:...:.:..||:| ..:|  |.....::|    :.:|.|..:.:.:.|
 Worm  1088 ANCMCSNLRIVNSHQLLEPAFLERVTKGIA-MSSW--FVLLENVDL----LDSQLIFKLFKILAS 1145

  Fly  1356 NATKFMFEGTELTLNPACYVCITMNPGYAGRSELPDNLKV----LFRSVAMMVPDYAMIGEIS-L 1415
            ..|.|          |..::..|...    :::||.|:.|    :|.....:.|.:..  |.| |
 Worm  1146 QVTSF----------PRLFLSSTDEI----KNQLPTNIAVEHLGVFHEFVEVSPAFKF--ETSPL 1194

  Fly  1416 YSYGFVDARKLAVKIVTTYRLCSEQLSSQNHYDYGMRAVKTVLSACGNIKKQYPDEVEDILLLRS 1480
            .|.......||..::|:|                                .|.|.....:||   
 Worm  1195 SSVRTSSIPKLPAQLVST--------------------------------GQPPSSPHSVLL--- 1224

  Fly  1481 LIDVNLPKFLSFDVPLFEGIISDIFPGIKLPHIDYSLVESEFKRVCLEEVLEPAPSFLLKVIQTY 1545
                             |.|      |.|:.:.:.|.......:..|:|.|:..|.   |:|..|
 Worm  1225 -----------------EKI------GAKIRNREISGCVGSLAKETLKETLQNFPE---KIIWVY 1263

  Fly  1546 EMIIVRHGFMLVGEPLAGKSKTLQVLAKVLS-ALKIKAPQKSNYFQHVQMGIMNPKSITMNQL-- 1607
            ..:.||...:...:..|....  .:|.:||| |........|....|   ..::..|:|:|.:  
 Worm  1264 TDVFVRDQMVTRSDEFAATQS--GILFEVLSPATTGNGGSDSERSYH---STISTSSVTINTIVV 1323

  Fly  1608 -YGSFDPISYEWT------------DGLVAKIFRDFAMTP---TPDRKWVIFDGPVDAVW-IENM 1655
             ||    .|..|.            ||..|:       ||   |.|      ||  ...| .||:
 Worm  1324 FYG----FSEFWNIFPFISPLFLKKDGYSAQ-------TPPFLTLD------DG--STYWPQENV 1369

  Fly  1656 NTVLDDNKKLCLTSGEVITMS--NEMSMVFEV------MDLAQASPATVSRCGMIYMEPSTLGWR 1712
            ..:      :|:...|...::  .:..:.|.|      ||:|::                   ||
 Worm  1370 QFL------MCIPDEEGFHLNTVKKFDIPFHVVNENLKMDVARS-------------------WR 1409

  Fly  1713 AFAKSWLKKADPRWADEEGVPYVMALMQWLLPPCQTFVRRFCSQFIKPGEFNCMLTTFDLFDMQI 1777
               |.|.||....:.....|..:..|:..:|.|   ....|.|.|:.|.      |.|.:....:
 Worm  1410 ---KVWHKKYTELFNKISLVEIMDELVDRILSP---MASHFKSTFLWPS------TLFQVIYHDL 1462

  Fly  1778 AEAIEENP-----------------------EDYQKYLQTYFQAAILFALIWGVGGVLDTASREK 1819
            .|.|..:.                       .|.|..::.|...|:             .|.|||
 Worm  1463 TEVIPTSRITSVNDTLRITVVLATANFISIFADDQGKVEKYMGRAL-------------GAIREK 1514

  Fly  1820 FDVFLKKLWDTDPPPPEPLGKMEITPPTEGLLVDYVFLYKQRGAWRYWPDLAKRMDVEETKTG-- 1882
            ..:.:          |:.:...:|:......||          .|...|.....:| :::..|  
 Worm  1515 LSIQM----------PDDICNWKISYQDATKLV----------RWEDEPFCQSSID-KDSAIGNI 1558

  Fly  1883 -VIVPTVDTARYIHLLKMHVEHKKRMLLVGPTGTGKTVYVQNYLMNKLDKEVFETGFITFTVMIS 1946
             ::.|.:|...:..:..:...|  .:|:.||..:.||::|:  :::|         |::.||   
 Worm  1559 MIVTPNMDRLLFYSIRLLASGH--NILVHGPPYSRKTMFVK--MISK---------FLSSTV--- 1607

  Fly  1947 ANQCQDLLISKLQKWKRGIYGPPKGMQSVLFVD-----DMNMPVKEVY-------GAQPPLELLR 1999
                .||.:..|  |..|.......:....|.|     :.....|::|       ..:|.|.::.
 Worm  1608 ----GDLTVEFL--WLDGKSRVGNDVAQKKFADVVGTCERAHQSKQLYIVIDRFSFTEPLLPIIE 1666

  Fly  2000 QFFDYGHVYDLKD----SSKVYIHNVLIMAACGLPGGSRQDVYARFLNHFNVYSINTFSDDSMFR 2060
            .|.|  |....||    :|...|..::|         :.::.|| :|:          ...::..
 Worm  1667 FFVD--HKTYWKDGKLCNSDAQIRMIII---------TDEEDYA-WLH----------KTKALAS 1709

  Fly  2061 IFLNVALNGFRRAGHGQDVFVVTNQIVSATQSIYKSVQSE----IRATPS------KSHYIFNLR 2115
            .|:.:|:....:.   :|...:...:::|..:. ||..||    :.:..|      :..|:.||.
 Worm  1710 TFVGIAMPASTKF---KDQKPLVQSLIAANFTA-KSFSSEYHHILESFSSCIVEIVRKPYVENLS 1770

  Fly  2116 DI---SRVVTGCTLVRKESVSDKKIFVRVWYHEAMRVFYDRLVDDVDRKWMFDKLNECLKANFKD 2177
            .:   :|:.........::..|....:|::.||:.||..| .:|.:.|.....:....:..||..
 Worm  1771 SMALATRLAKSFFFAFPDNCPDPDALLRLFIHESARVIGD-AIDPIHRATFAQQFETLIDENFNT 1834

  Fly  2178 KVETVFERYC----VQGPDEAVFTMEAASNILFGVYF---DEDSVPDERRYEEV-------PSVE 2228
            ..:.:.:...    .:..:|.|.....||..:|.:.:   |...|.|...||.|       .|:|
 Worm  1835 AFQAILKHIAQISEEEEEEEGVEKRMTASLDMFDLIYSEVDAHDVVDGLAYEPVVDRVQFQRSIE 1899

  Fly  2229 VFLNLALTSLDDYNSTRRNKMDITLFTFALQHLNRICRIISIQGASALIIGLGGSGRQSLTKL-- 2291
            .||      .:.:.:..::::.:.:.......:.|:.|:|.......::.....|||..:.|.  
 Worm  1900 NFL------FEHHRNHTKDRVRLFVDWETSGWVQRVMRVIRQASEHMVLTAPPNSGRTQVVKAAC 1958

  Fly  2292 ----ATNM---VQTSFFQPEITKNYGANDWHDDIKAILKEAGGMNKHTTFLI------------T 2337
                ||.|   |..:.:...|::      |...:...:......|:|...|:            .
 Worm  1959 VACNATMMHMQVDATCYDTFISR------WEYALSRAINIIANTNQHVVILVHLDFCYEKVEPRW 2017

  Fly  2338 ENQIKMELFLQDIDCLLNQGEVPNIFPI--DEK-----QEVLEMVR-LAAQGGNRNIDVSALQVF 2394
            ..|||:.:            |.||...:  ||:     ::::|..: ||.|.....:.:...::.
 Worm  2018 MEQIKLWI------------ECPNTQHLVSDEQLHTMGEQLIECEKNLATQMQTIGLRLPGQRMC 2070

  Fly  2395 SFF-VDRCK--QKLHMILSFSPIGDALRTRVRLYPSL---VNCCTIDWYDSWPEEALQMIAKMSL 2453
            .:. |:..|  |.|..:|. :.|.|||.....:.|..   .:.|||  :.....|..::::|:|.
 Worm  2071 KYLPVETLKEPQALRKVLE-ARIFDALHVMFLVDPQFKTDFSWCTI--FHVPTIEKSELLSKVSK 2132

  Fly  2454 VDVNVPSEDIKLAIMDTCQYFHTTAARSTRAFCQMTGRHIYQTNAS-FIELIRSFQTLIERKQSE 2517
            :..:...::....|:.|  :|      ..:.:.|..|..:|.|..| ..|:...||.:...::.|
 Worm  2133 IISDCKVDEAAQIIVST--FF------IVKKYLQSIGIALYGTVFSQLFEVADCFQIVFREQKKE 2189

  Fly  2518 TMLAKMRYIGGLDTLAQAAAAISI-MQRDLNALQPKLVALAESSRKM---------MLEINKETL 2572
            .:....|....|.|..|......: .:.|:.|:|.::|.......||         .:|:..|.:
 Worm  2190 LVAEGTRLNEALHTCEQIEKLAEMGKEVDIEAVQRRIVEKETMLSKMNRERNTKGARMEVLSELV 2254

  Fly  2573 AASAAAEQVKRDEEVASVQAEAAQVLKQDCERDLAKAIPVLEDALAALNTLKPADITLVKSMKNP 2637
            |..|...:..|.||.|......|.|...  :.:..|.:   |:.|...||    ||..:..:..|
 Worm  2255 AVKATNLETMRAEEAALKTTVEAMVSAP--QEEFRKCV---EELLKFSNT----DIKTLSKITKP 2310

  Fly  2638 PPVIKLVMAAVCVI--KGIPPERIPDPASGKMVQDYWGPSKRLLGEMNFLPGLKEFDKDNIPTEI 2700
            ...|:|....:..|  ....|:|        ...:.|..|.:.:.:..|...|...|.|.:..:.
 Worm  2311 SVGIRLCCEMLRTIFEPNFKPKR--------HAAEAWTESLKFVSDKAFFIKLATCDADILTVDQ 2367

  Fly  2701 VKRIHKEFIPNKDFDPKVVAKASSAAKGLCQWIIAMMMYDEVAKVVAPKKAKLAGAEKEYADTME 2765
            :| :.|:::...:|:...:...|.....||:||                     ||..|.|.|:.
 Worm  2368 MK-VLKKYVDRAEFNANKIEHESVVCACLCRWI---------------------GAFLELACTLR 2410

  Fly  2766 FLAQKRALALALEEKVALLNIELDKANAEMQKTEEHAES------------------CRNKLLRA 2812
            .:.::...:..|.|.:....:..:..::|||:.:...|.                  |..: ||:
 Worm  2411 VMEEQVEESKELREHIRQTEVRFENESSEMQQLKSDVEKLTVLIRENEQVLANDRRLCDYR-LRS 2474

  Fly  2813 EALIGGLGGEKSRWNKAAEDLQELYDHLPGDVLISCGIIAYLSAVNLQYRSECVKDWFKKVTDLK 2877
            ..|:..|...:.||....:..::....|.|:.|:.....|:|..........||.          
 Worm  2475 GDLLAALEPHRKRWKSQLKQNEKKQKELVGNTLLFAIHRAHLLCQEKAVTLICVS---------- 2529

  Fly  2878 IPCSSHYSITDVLGLEVTIQNWQLDGLPNDEFSSENAI-----ISANSSRYSLFIDPQAQANNWL 2937
             .|:||          :|.||.|.|   :...||.|.|     ...:|.|:.||:   :..::.|
 Worm  2530 -MCTSH----------LTSQNVQFD---SSMASSSNVINRILRTLKSSRRFCLFL---STTDSLL 2577

  Fly  2938 KNMERKNRLNCVKFNQSNYMKVIAEALEYGTPVIIENVQEEL------------EVPLDPILMRQ 2990
            :|:..       ....:.|:. |:..|.:..|.:..::|:.:            |||  |..|.:
 Worm  2578 QNVRS-------VLPGATYLD-ISPPLTWKEPQMAVSLQKHVYSIVPTVFYNLTEVP--PPEMYE 2632

  Fly  2991 TFVQGGIKHISLGESVVPVNPNFRLYMTCNLRNPHFLPETFNKVTVINFALTQNALMDQLLSIVV 3055
            ..::...|.:                  |....|..||                   |.:|.:.|
 Worm  2633 ILMKSEEKEV------------------CYHNKPLELP-------------------DDILFVFV 2660

  Fly  3056 AKER---PD-----LQELRITLTTEAAANKGALRDAENMILKTLSA------GGDILENEAAIQI 3106
            ||..   ||     ::.:.:::..|      .:.|.|.:....||:      ..||||       
 Worm  2661 AKNLGHIPDQIRKLMEVIVVSIPLE------PIEDREKIERNELSSLLGEFTAADILE------- 2712

  Fly  3107 LADSKGLSKDIVEK 3120
                   |:|:..|
 Worm  2713 -------SRDLTRK 2719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhc62BNP_995958.2 DHC_N2 678..1102 CDD:285579 85/439 (19%)
P-loop_NTPase 1239..1469 CDD:304359 36/238 (15%)
P-loop_NTPase 1553..1699 CDD:304359 34/173 (20%)
P-loop_NTPase 1874..2145 CDD:304359 52/302 (17%)
P-loop_NTPase 2249..2511 CDD:304359 55/297 (19%)
MT 2524..2864 CDD:289543 70/369 (19%)
AAA_9 2898..3111 CDD:289547 44/243 (18%)
Dynein_heavy 3253..3952 CDD:281078
dhc-4NP_001338793.1 DHC_N2 599..990 CDD:369852 89/500 (18%)
SMC_prok_A <2413..>2502 CDD:274009 13/89 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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