DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc62B and DNAH6

DIOPT Version :9

Sequence 1:	NP_995958.2	Gene:	Dhc62B / 38226	FlyBaseID:	FBgn0013811	Length:	3964	Species:	Drosophila melanogaster
Sequence 2:	NP_001361.1	Gene:	DNAH6 / 1768	HGNCID:	2951	Length:	4158	Species:	Homo sapiens

Alignment Length:	4286	Identity:	1414/4286 - (32%)
Similarity:	2217/4286 - (51%)	Gaps:	520/4286 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ASDITKYDNEPYMKNPLLKFRISE-------VHERRHYQFLKQKAADVKVRVARQQWQPEPDMRL 70
            |.:.|:...:|....||...::.:       :||:..:|.:........|.:|::.:.......|
Human    59 AQEKTRKRQQPIKLEPLPVLKVYQDHKQPEYIHEQNRFQLMTAGIIKRPVSIAKKSFATSSTQFL 123

  Fly    71 LPQSHYEDNLRREVRKIVV------PPMLRRTEAKILSFASERLKNKYP--------ELVQAYMH 121
               .|.:...:.::.:..|      ||.|..|..........| .:.||        |:|:|.:.
Human   124 ---EHQDAVKKMQIHRPYVEVFSPSPPKLPHTGIGKRGLFGTR-SSAYPKYTFHDREEVVKANIR 184

  Fly   122 D----------------------------VHEEFNRLMKVYSMKNILRHPEFSDEDPAQFELPRP 158
            |                            .::.:|  :||.|.:||.::..::....|...:...
Human   185 DPLQIIKIIRENEHLGFLYMIPAVPRSSIEYDTYN--LKVVSYENINKNDYYTISQRAVTHIYNE 247

  Fly   159 DIGFRRPGRTQN----------------------YSNFLEN---------RRRIAQKLLILQLPL 192
            ||.|....|.:.                      :|.:.:|         ::.:.:.|.|:...|
Human   248 DIEFIEIDRWEQEYLYHRELTKIPIFSLFRKWKAFSVWRKNVRSKKITGCQKSLQKNLFIVNPHL 312

  Fly   193 R-AILNIS---------------------------------------VGE-------LPKLACIF 210
            | |:|.|:                                       :||       :.:.||.|
Human   313 RPALLKINELCYHLSFMGLCYIEKCHTYTLQEFKAAQVIRLAEVTERLGEFRNEAKYVVRRACRF 377

  Fly   211 NYVLATGAMQQQLGLGGREALSYKFYHKYIQNQLDKVNTFLRWTWY---PKIVQVLRKLMRKRVM 272
             .:.|.|.:......|     .::.||| :|:....:||......|   .|:....:...|...|
Human   378 -ALRAAGFVPDDCAFG-----PFEDYHK-VQSSGSFINTPHELPTYGDSEKMTYTEQASKRHYCM 435

  Fly   273 PMSTWKRSWNAMEALMNREM--TNMKIRTFEEMYRMCSHPRTMPMMRMSLEWSEFSSDLDTRPNA 335
            .::.:.|        :|..:  ..|.|.|...:..:.:|               .:..|...|:|
Human   436 RLTCFIR--------LNDYLIENTMHILTVNAVNSLLNH---------------LTDKLKRTPSA 477

  Fly   336 WSILRTFAEIATEI-SMVGYRMEPLQPQVQTLTSM---AAYAKVNDYLKIEMNDNFLKDVIDKV- 395
            ..|.:...|...|: ...|..|...|.:.::|..|   .....|...|.....::||..::..|
Human   478 DVIQKWITEEKPEVPDKKGTLMVEKQEEDESLIPMFLTELMLTVQSLLFEPSLEDFLDGILGAVN 542

  Fly   396 --QNIILRTYQEV-IQYVEGFRDKYY-------------ALYSWQERDA-LNQFLSEPHE----- 438
              ||.:|.....| ..|.:.|...|.             :|.:..|.|. .:..:|:..|
Human   543 HCQNTVLSVPNLVPDSYFDAFTSPYINNKLEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAA 607

  Fly   439 FEE---YFARIDMYYGF--------IQMLR-SEPATEYF--VMAVIHNE--------PA------ 475
            ||.   |.|..:.:..|        :|.|: .||...:|  .:...|.:        |.
Human   608 FESARIYAATFEKFQIFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLL 672

  Fly   476 IFGLRTLAENLIH------EITTIIIREHIKAEVD-ICDEFEKIKYRALEIPKSTEELLESAEYM 533
            :...|.|.|.||.      |:...::....|.:|| |..|.:..:|:...:|.:|.|.:.|..:
Human   673 LIDTRLLREKLIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLF- 736

  Fly   534 IHVKKDKIAELTDRIQYCLQVGTNIVELTE-MSKYHFD---------LTIKTINWIKDINDICDY 588
                   :.|:.:||:.....|..:.::.: |.:|...         .|:|..  |..:.:..|.
Human   737 -------LDEIQERIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKPS--IVAVRNAIDK 792

  Fly   589 NASQQEQFKFTFEEHLQEVIKKLNSDIDELLPKL-----TVIDDMSRPDKFRDSYIILQNFIDQL 648
            :...:|.....|..||...:::||::::|:  ||     .::|..:..||.|   :||.|....|
Human   793 SVGDRESSIKQFCVHLGSDLEELNNEVNEV--KLQAQDPQILDISADQDKIR---LILNNLQSVL 852

  Fly   649 KTFDDYVAWINKEEKLFKVALTEYPKLDIIKTFVYPFAEL-MKCCI-----EWQRYLSVWNDGPF 707
            .............:|.|||.::::..|:.:.      ||| :|..:     ||.:....|....|
Human   853 ADLQKRAFQYKSYQKNFKVEVSKFEALEEVS------AELKLKQLLWDSFSEWDKLQQEWLKSKF 911

  Fly   708 EYLEPQFVERTTDDYLKEFQKNQKYYRVKIKQDLIDN---PVCKFKGQTEDPDPAKHPVPLRLCT 769
            :.|:|:.:......|.|        :..::::.|..|   |..|:|     .:..|..:|
Human   912 DCLDPEVLNGQVSKYAK--------FVTQLEKGLPPNSVVPQLKYK-----VEKMKEKLP----- 958

  Fly   770 SMIQSIKDFTTGVFIVNTMCNPALRKRHWKEMSEIAGFDVTPDAGTTLRKILNSGLDPI----LD 830
                          ::..:.||.|:.|||      |..:.|.||.....:|      |:    |.
Human   959 --------------VIIDLRNPTLKARHW------AAIEQTVDATLVDAEI------PLTLERLS 997

  Fly   831 QFEIISIGANKELQLWN-------ALQAMIKE----WETRVFPYGPYKET-GVQILSSLDDIQAL 883
            |..:...|  :|:|..:       ||:|::|:    |:|..|...|:::: .|.||...||||.|
Human   998 QLHVFDFG--QEIQDISGQASGEAALEAILKKVEDSWKTTEFVILPHRDSKDVFILGGTDDIQVL 1060

  Fly   884 LDDHILKTLVMRGSAFMKPCEEEVRAWYEKIMRVNETLDQWGKVQANYLYLLPIFSSKDIVAQMP 948
            |||..:....:..|.::.|.:..|..|.:::...|:||::|...|.|:|||..||::.||..|:|
Human  1061 LDDSTINVATLASSRYLGPLKTRVDEWQKQLALFNQTLEEWLTCQRNWLYLESIFNAPDIQRQLP 1125

  Fly   949 EEGRLFVIVEQTYTRNMGLVLRQPLVMETAPVSGLLESLQKANELLEDIATGVSNYLEKKRLYFP 1013
            .|.::|:.|::::...|..|.|.|..:..|...||||:.|..|.||:.|...:..|||.||:.||
Human  1126 AEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFP 1190

  Fly  1014 RFFFLANDEMLEILSETKDPLRVLPHLSKCFEGINSLEFDA-------------------AKNVL 1059
            ||:||:|||:||||::|::|..|.|||.|||:.|:.|||..                   ..::|
Human  1191 RFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPAEGKIPGIDGEPEKVYTNDIL 1255

  Fly  1060 AMISSDKETIEFIEQVSTAAAGGSVEKWLIGVEDEMLKAVRYQNELSFAHYPKVKRHEWVLE-WP 1123
            ||:|.:.|.:...:.:.   |.|:||:||..||:.|..::|...:.:.|.|....|.:||:. .|
Human  1256 AMLSPEGERVSLGKGLK---ARGNVEEWLGKVEEAMFTSLRRLCKAAIADYQGKLRTDWVVAGHP 1317

  Fly  1124 QMTVLAISQVYWASRVHGCLRRTFGGNMTIMMNFFQELSKELNDIVTLVRSPKISNLNRITIKSL 1188
            ...:|.:||:.|...:..||......::..:.||.:...:.||.:..:|:. .:..|:|..:.:|
Human  1318 SQVILTVSQIMWCRDLTECLETEHSNHIQALKNFEKVNFERLNALAAIVQG-SLPKLHRNILTAL 1381

  Fly  1189 IVIDVHAKDVSEDLIKNKVSSEFDFQWLAQMRYYWED--DKTWVRIINATVPFANEYLGNSDRLV 1251
            |.|||||:|:..:|:::||.:...|.|..|:||||:.  |....|:..:...:..||||...|||
Human  1382 ITIDVHARDIVTELVQSKVETVESFDWQRQLRYYWDIDLDNCVARMALSQYTYGYEYLGACPRLV 1446

  Fly  1252 ITPLTDRCYRTLVGAYQLHLNGAPEGPAGTGKTETTKDLAKALAVQCKVFNCSDGLDYKAMGKFF 1316
            |||||||||..|:||.||.|.|||.|||||||||||||||||||:||.|||||||||||.||:||
Human  1447 ITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFF 1511

  Fly  1317 KGLASCGAWACFDEFNRIELEVLSVVAQQILLIIQAVRSNATKFMFEGTELTLNPACYVCITMNP 1381
            .|||..|||.||||||||::|||||:|||::.|..|..:..::|||||.|:.|...|...|||||
Human  1512 SGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNP 1576

  Fly  1382 GYAGRSELPDNLKVLFRSVAMMVPDYAMIGEISLYSYGFVDARKLAVKIVTTYRLCSEQLSSQNH 1446
            |||||:|||||||.|||..|||||:||:|.|:.|||.||..::.||.|:...|:|||||||.|:|
Human  1577 GYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDH 1641

  Fly  1447 YDYGMRAVKTVLSACGNIKKQYPDEVEDILLLRSLIDVNLPKFLSFDVPLFEGIISDIFPGIKLP 1511
            ||:||||||:||...|::|::.||..||::|:|:|.|.||||||:.|..||.|||||:|||:::|
Human  1642 YDFGMRAVKSVLVMAGSLKRENPDLNEDVVLIRALQDSNLPKFLTDDALLFSGIISDLFPGVQIP 1706

  Fly  1512 HIDYSLVESEFKRVCLEEVLEPAPSFLLKVIQTYEMIIVRHGFMLVGEPLAGKSKTLQVLAKVLS 1576
            ..||.:::|....|...:.|:|....:.||||.||.::||||.||||....||:...::||:.|.
Human  1707 EHDYGILQSTIVDVMNRQNLQPEMCMVRKVIQFYETMLVRHGVMLVGPTGGGKTTVYRILAETLG 1771

  Fly  1577 ALKIKAPQKSNYFQHVQMGIMNPKSITMNQLYGSFDPISYEWTDGLVAKIFRDFAMTPTPDRKWV 1641
            .|: |...:::::|.|:..::|||||||.:|||..:.::.||.|||:|...|......:.|.||:
Human  1772 NLQ-KLGIENSFYQAVKTYVLNPKSITMGELYGEVNNLTLEWKDGLMALSVRAAVNDTSEDHKWI 1835

  Fly  1642 IFDGPVDAVWIENMNTVLDDNKKLCLTSGEVITMSNEMSMVFEVMDLAQASPATVSRCGMIYMEP 1706
            |.||||||:|||||||||||||.|||.:.|.|.::.::.|:|||.||..|||||||||||::::|
Human  1836 ISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLRVASPATVSRCGMVFVDP 1900

  Fly  1707 STLGWRAFAKSWLKKADPRWADEEGVPYVMALMQWLLPPCQTFVRRFCSQFIKPGEFN------C 1765
            ..|.|..:.|:|:|....: ..||...|::.|.|..:.....|:.:.|||.|...:.:      |
Human  1901 EELKWMPYVKTWMKGISKK-LTEETQEYILNLFQRYVDEGLHFINKKCSQAIPQVDISKVTTLCC 1964

  Fly  1766 MLTTFDLFDMQIAEAIEENPEDYQKYLQTYFQAAILFALIWGVGGVLDTASREKFDVFLKKLWDT 1830
            :|.:..|....:..|:|      |..|.|......:|..:|.:||.|.....:.||.|::..:|.
Human  1965 LLESLILGKDGVNLAME------QTKLNTILCQTFVFCYLWSLGGNLTENYYDSFDTFIRTQFDD 2023

  Fly  1831 DPPPPEPLGKMEITPPTEGLL--VDYVFLYKQRGAW-RYWPDLAKRMDVEETKTGVIVPTVDTAR 1892
            :|         :...|..|.|  :...|..|:...| |..|......||...:  ::|||.||.|
Human  2024 NP---------DARLPNSGDLWSIHMDFDTKRLDPWERIIPTFKYNRDVPFFE--MLVPTTDTVR 2077

  Fly  1893 YIHLLKMHVEHKKRMLLVGPTGTGKTVYVQNYLMNKLDKEV-FETGFITFTVMISANQCQDLLIS 1956
            |.:|::..:..|..:|..|.||.||:|..:. |:||:.:.. :...::.|:...|:.:.|:::.|
Human  2078 YGYLMEKLLAVKHSVLFTGITGVGKSVIAKG-LLNKIQESAGYVPVYLNFSAQTSSARTQEIIES 2141

  Fly  1957 KLQKWKRGIYGPPKGMQSVLFVDDMNMPVKEVYGAQPPLELLRQFFDYGHVYDLKDSSKVY---I 2018
            ||::.::.|.|.|...:.|:||||:|||..:.||:|||:|||||:.|:|..|   |.:|::   |
Human  2142 KLERKRKNILGAPGNKRIVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFY---DRNKLFWKEI 2203

  Fly  2019 HNVLIMAACGLPGGSRQDVYARFLNHFNVYSINTFSDDSMFRIFLNVALNGFRRAGHGQDVFVVT 2083
            .:|.|::||..|||.|..|..||:.||::..:...|:.|:.:|| ...|||| .:.....|....
Human  2204 QDVTIISACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIF-QAILNGF-LSDFPPAVKQTA 2266

  Fly  2084 NQIVSATQSIYKSVQSEIRATPSKSHYIFNLRDISRVVTGCTLVRKESVSDKKIFVRVWYHEAMR 2148
            :.||.|:..||..:..::..||:||||:|||||:|:.|.|.......::.::....|::.||..|
Human  2267 SSIVEASVEIYNKMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHECQR 2331

  Fly  2149 VFYDRLVDDVDRKWMFDKLNECLKANFKDKVETVFERYCVQGPDEAVFTMEAASNILFGVYFDED 2213
            ||:|||:::.|:.:....|.|....:|...::.   .|.:..|            |:||.:....
Human  2332 VFHDRLINNEDKHYFHVILTEMANKHFGIAIDL---EYFLNKP------------IIFGDFIKFG 2381

  Fly  2214 SVPDERRYEEVPSVEVFLNLALTSLDDYNSTRRNKMDITLFTFALQHLNRICRIISIQGASALII 2278
            :...:|.|:::|.:|...|:....|||||.|...::.:..|..|::|::||.|:|..:..:||::
Human  2382 ADKADRIYDDMPDIEKTANVLQDYLDDYNLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLV 2446

  Fly  2279 GLGGSGRQSLTKLATNMVQTSFFQPEITKNYGANDWHDDIKAILKEAGGMNKHTTFLITENQIKM 2343
            |:||:|:||||:||.::......|.|:::.|..:.:|:|::.:.|.||..:|:..||.|:.||.:
Human  2447 GVGGTGKQSLTRLAAHICGYKCLQIELSRGYNYDSFHEDLRKLYKMAGVEDKNMVFLFTDTQIVV 2511

  Fly  2344 ELFLQDIDCLLNQGEVPNIFPIDEKQEVLEMVRLAAQ-----GGNRNIDVSALQVFSFFVDRCKQ 2403
            |.||:||:.:||.|||||:|..||.::||...|..|:     .|||:      :||.:|:.:.:|
Human  2512 EEFLEDINNILNSGEVPNLFEKDELEQVLAATRPRAKEVGISEGNRD------EVFQYFISKVRQ 2570

  Fly  2404 KLHMILSFSPIGDALRTRVRLYPSLVNCCTIDWYDSWPEEALQMIAKMSLVDVNVPSEDIKLAIM 2468
            |||::|..||:|:|.|:|.|::|||||||||||:..||.|||..::|.....|:..:|::|..:.
Human  2571 KLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKTFFSQVDAGNEELKEKLP 2635

  Fly  2469 DTCQYFHTTAARSTRAFCQMTGRHIYQTNASFIELIRSFQTLIERKQSETMLAKMRYIGGLDTLA 2533
            ..|...|.:.:.....:.....|..|.|..|::|||..:.:::..|:.:.:.|:.|...||..|.
Human  2636 LMCVNVHLSVSSMAERYYNELRRRYYTTPTSYLELINLYLSMLSEKRKQIISARDRVKNGLTKLL 2700

  Fly  2534 QAAAAISIMQRDLNALQPKLVALAESSRKMMLEINKETLAASAAAEQVKRDEEVASVQAEAAQVL 2598
            :....:..|:.||:||:|.|:|.:|....:|.::..:..:|......|:.||..|.|:||..|.:
Human  2701 ETNILVDKMKLDLSALEPVLLAKSEDVEALMEKLAVDQESADQVRNTVQEDEATAKVKAEETQAI 2765

  Fly  2599 KQDCERDLAKAIPVLEDALAALNTLKPADITLVKSMKNPPPVIKLVMAAVCVIKGIPPERIPDPA 2663
            ..|.:|||.:|:|.|:.|..||::|..|||:.::....||.::..||.|:.::....|:
Human  2766 ADDAQRDLDEALPALDAANKALDSLDKADISEIRVFTKPPDLVMTVMEAISILLNAKPD------ 2824

  Fly  2664 SGKMVQDYWGPSKRLLGEMNFLPGLKEFDKDNIPTEIVKRIHKEFIPNKDFDPKVVAKASSAAKG 2728
                    |..:|:|||:.|||..|.|:||:||..:|:.::.| :|.|.||.|:.|.|.|.|.|.
Human  2825 --------WPSAKQLLGDSNFLKRLLEYDKENIKPQILAKLQK-YINNPDFVPEKVEKVSKACKS 2880

  Fly  2729 LCQWIIAMMMYDEVAKVVAPKKAKLAGAEKEYADTMEFLAQKRALALALEEKVALLNIELDKANA 2793
            :|.|:.||.:|..|.|||.||:.||..|:.|...||..|.:|:||...:|:::..|..|.||...
Human  2881 MCMWVRAMDLYSRVVKVVEPKRQKLRAAQAELDITMATLREKQALLRQVEDQIQALQDEYDKGVN 2945

  Fly  2794 EMQKTEEHAESCRNKLLRAEALIGGLGGEKSRWNKAAEDLQELYDHLPGDVLISCGIIAYLSAVN 2858
            |.:...:.....:.:|:||..|...|..|:.||.::.:..:|...::.|:|.|:...:||..|..
Human  2946 EKESLAKTMALTKARLVRAGKLTAALEDEQVRWEESIQKFEEEISNITGNVFIAAACVAYYGAFT 3010

  Fly  2859 LQYRSECVKDWFKKVTDLKIPCSSHYSITDVLGLEVTIQNWQLDGLPNDEFSSENAIISANSSRY 2923
            .|||...::.|.:....|:||....:|:.::||....|:.|..||||.|..|:||.|:.....|:
Human  3011 AQYRQSLIECWIQDCQSLEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLISTENGILVTQGRRW 3075

  Fly  2924 SLFIDPQAQANNWLKNMERKNRLNCVKFNQSNYMKVIAEALEYGTPVIIENVQEELEVPLDPILM 2988
            .|.||||.|||.|::|.|.|:.|..:|...||:::::..::..|.||::|.::|.|:..|:|||:
Human  3076 PLMIDPQDQANRWIRNKESKSGLKIIKLTDSNFLRILENSIRLGLPVLLEELKETLDPALEPILL 3140

  Fly  2989 RQTFVQGGIKHISLGESVVPVNPNFRLYMTCNLRNPHFLPETFNKVTVINFALTQNALMDQLLSI 3053
            :|.|:.||...|.||:|.:..:.|||.|||..:.|||:|||...|||:|||.:|::.|.|||||.
Human  3141 KQIFISGGRLLIRLGDSDIDYDKNFRFYMTTKMPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSD 3205

  Fly  3054 VVAKERPDLQELRITLTTEAAANKGALRDAENMILKTL-SAGGDILENEAAIQILADSKGLSKDI 3117
            ||..|:|.|:|.||.|......:|..|:..|..||:.| ::.|:||:||..|..|.|||..|..|
Human  3206 VVRLEKPRLEEQRIKLIVRINTDKNQLKTIEEKILRMLFTSEGNILDNEELIDTLQDSKITSGAI 3270

  Fly  3118 VEKQEAAKETVAKIEAFRLNYKPVAVHSSILYYSITDLPNIDPMYQFSLNWYINLYMYSIETANK 3182
            ..:.|.|:.|...|...|..|:|||...|::|:.|..|..||||||:||.::..|:..:|||:.|
Human  3271 KTRLEEAESTEQMINVAREKYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSVK 3335

  Fly  3183 SKDLPRRIKFLVDGFTRNLYNNVCRSIFEKDKLLYSFILTARILLGTG---QVEMRHFAHLVTNA 3244
            :::|.:|:..|::......|.||.|.:||:.||:|||:|...::...|   ..|...|  |..:|
Human  3336 TENLQQRLDVLLEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEMMRQQGTLSDAEWNFF--LRGSA 3398

  Fly  3245 KESTNIPPNPDPTWITETVWLNVLRLEE-LKELRGIVDHFKSH--------------LHAWQAIY 3294
            ......||.|:..|:....|.....||| .....|:..:..||              ...|:. |
Human  3399 GLEKERPPKPEAPWLPTATWFACCDLEESFPVFHGLTQNILSHPISIRLGSFETYINPQKWEG-Y 3462

  Fly  3295 D-------HSSPEKQPL-PPPWQDKTTAFEKIIVLKALRPDSVFLAVRLFIAESIGDQYVTPPEF 3351
            .       |...||:.. ..||....::|.|:|::|..:.:.|..|:..|:.|::|.|::..|..
Human  3463 SKMKHEDKHMRQEKEAAHQDPWSAGLSSFHKLILIKCCKEEKVVFALTDFVIENLGKQFIETPPV 3527

  Fly  3352 DISKSYADSTALTPLVFILSPGADPLGSLLAFAEKMGQEETFQSISLGQGQGPIATALIKNAQEM 3416
            |:...|.|.:..||||||||.|:||:|:...||.:.|..|..|||||||||||||..::|:|.:.
Human  3528 DLPTLYQDMSCNTPLVFILSTGSDPMGAFQRFARESGYSERVQSISLGQGQGPIAEKMVKDAMKS 3592

  Fly  3417 GYWVCLQNCHLAASWMPYLEYLWENMDTFNTTPN------FRIWLTAYPTPQFPVTILQNGVKMT 3475
            |.||.|||||||.|||..:|   |.:.|| |.|:      ||::|::.|:..||||:|||.||:|
Human  3593 GNWVFLQNCHLAVSWMLAME---ELIKTF-TDPDSAIKDTFRLFLSSMPSNTFPVTVLQNSVKVT 3653

  Fly  3476 NEPPTGLKENLMRSYNS-EPINDYEFYTGCAKQDRAFTRLLYGICFFHAVVQERRKYGPLGWNIA 3539
            ||||.||:.|:.|::.. .|....|...|     :.:.::::|||||||::|||:|:|||||||.
Human  3654 NEPPKGLRANIRRAFTEMTPSFFEENILG-----KKWRQIIFGICFFHAIIQERKKFGPLGWNIC 3713

  Fly  3540 YGFNESDLQISVLQLSMLLNQYDHVPYDAISYLTSECNYGGRVTDNWDRRLIVTILADFCNAQAV 3604
            |.||:||.:.::|.|.:...: ..:|:||:.|:|.|..|||||||:||:|.:.|||..|.:.:.:
Human  3714 YEFNDSDRECALLNLKLYCKE-GKIPWDALIYITGEITYGGRVTDSWDQRCLRTILKRFFSPETL 3777

  Fly  3605 TDNRYRFASDDRYILPRKTEHREILRYLDENLPSLAPPEVYGLHANSGITRDLQTTKTLLDSMIL 3669
            .:: |:::....|..|.....:|...|: ||||.:..||::|:|.|:.:....:.|.||:::::.
Human  3778 EED-YKYSESGIYFAPMADSLQEFKDYI-ENLPLIDDPEIFGMHENANLVFQYKETSTLINTILE 3840

  Fly  3670 LLGSEAAGSAGAGVSVEQVILDTIKQIEREMPADMDIEAAAEK-YPVDYN---ESMNTVVVQEME 3730
            :....:.|  |.|.|.::::.:.:..::..:|..:::|.|:|. :..|..   .|:.||:.||::
Human  3841 VQPRSSTG--GEGKSNDEIVQELVASVQTRVPEKLEMEGASESLFVKDLQGRLNSLTTVLGQEVD 3903

  Fly  3731 RFLKLQKEIRTTCRDLAMGIKGIIVMTPDLENVMTAMKFNRIPTKWMSKSYPCLKPLGSYVQDLY 3795
            ||..|.|.|.|:...|...|.|.:||:.::|.|..:...|::|..|.:.:||.||||||:|:||.
Human  3904 RFNNLLKLIHTSLETLNKAIAGFVVMSEEMEKVYNSFLNNQVPALWSNTAYPSLKPLGSWVKDLI 3968

  Fly  3796 KRLNWLHDWHHHGKPPTFWLSGFFFTQAFLTGAMQNFARKYKIPIDTLTFDYDV----------- 3849
            .|.:::..|...|:|.::|:|||||.|.||||.:||.||||.:|||.|:|.|.|
Human  3969 LRTSFVDLWLKRGQPKSYWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYSVIPTYRDQAAVI 4033

  Fly  3850 -----------LKVETKTSPPDDGVYCNGLYLEGARWEWRENTLVEQFPKVLIYAMPVIFFRPVG 3903
                       |.::.:...|:|||..:|::::.:||:.:|..:.:..|..:...:||:.|.|..
Human  4034 EAAKTVQFGQELPMDMELPSPEDGVLVHGMFMDASRWDDKEMVIEDALPGQMNPVLPVVHFEPQQ 4098

  Fly  3904 LVDVVEGSRYRCPLYKTAERKGTLSTTGHSTNYVVPLLLNTHVKASHWVKRSVALICQTSD 3964
            ... ...:.|.||||||..|.|||||||||||:||.:||.:.....:|:.:..||:||.|:
Human  4099 NYK-PSPTLYHCPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDYWIAKGSALLCQLSE 4158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc62B	NP_995958.2	DHC_N2	678..1102	CDD:285579	137/467 (29%)
		P-loop_NTPase	1239..1469	CDD:304359	152/229 (66%)
		P-loop_NTPase	1553..1699	CDD:304359	72/145 (50%)
		P-loop_NTPase	1874..2145	CDD:304359	96/274 (35%)
		P-loop_NTPase	2249..2511	CDD:304359	99/266 (37%)
		MT	2524..2864	CDD:289543	114/339 (34%)
		AAA_9	2898..3111	CDD:289547	93/213 (44%)
		Dynein_heavy	3253..3952	CDD:281078	273/754 (36%)
DNAH6	NP_001361.1	Stem. /evidence=ECO:0000250	1..1433		332/1480 (22%)
		DHC_N2	882..1300	CDD:285579	137/472 (29%)
		P-loop_NTPase	1434..1664	CDD:304359	152/229 (66%)
		AAA 1. /evidence=ECO:0000250	1434..1655		150/220 (68%)
		AAA 2. /evidence=ECO:0000250	1715..1948		101/234 (43%)
		P-loop_NTPase	1748..1893	CDD:304359	72/145 (50%)
		P-loop_NTPase	2057..2328	CDD:304359	96/278 (35%)
		AAA 3. /evidence=ECO:0000250	2058..2306		94/255 (37%)
		AAA 4. /evidence=ECO:0000250	2408..2659		96/256 (38%)
		P-loop_NTPase	2409..2678	CDD:304359	102/274 (37%)
		Stalk. /evidence=ECO:0000250	2676..2961		98/299 (33%)
		MT	2690..3022	CDD:289543	114/346 (33%)
		AAA 5. /evidence=ECO:0000250	3042..3272		100/229 (44%)
		AAA_9	3050..3266	CDD:289547	95/215 (44%)
		Dynein_heavy	3407..4146	CDD:281078	273/754 (36%)
		AAA 6. /evidence=ECO:0000250	3509..3730		108/229 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56321
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000321
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720