DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8001 and AT4G35140

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001329237.1	Gene:	AT4G35140 / 829666	AraportID:	AT4G35140	Length:	541	Species:	Arabidopsis thaliana

Alignment Length:	494	Identity:	164/494 - (33%)
Similarity:	241/494 - (48%)	Gaps:	53/494 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 WRG--GHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWD 354
            ||.  |..|:.:|...:..|..:|.::.:...|..|.||||:::||..||::.|||||..:|:||
plant    23 WRREVGGISSRNFSNRFSASENLVLRLEIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87

  Fly   355 WAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESV 419
            |........|.|||..|:||.||:..:....||:.:.||.|||:.| ..|..::...|..|....
plant    88 WQLGNVKLSFHSGHANNVFQAKFMPFSDDRTIVTCAADGMVRRASI-LEGDKVETSFLGLHQGRA 151

  Fly   420 HKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERG--RVRLFSIAHHPYAPE 482
            ||:.:.|.:.|...:.|||..|:.|||| :.|.|.:..|...|...|.  .::|.:||..|....
plant   152 HKLCIEPGNPHIFYTCGEDGLVQRFDLR-TEAPTELFTCRSVDPRRRNMDAIQLNAIAIDPRNSN 215

  Fly   483 -FCVSGSDDILRVYDKR--------NLAKAIHQMAPRNLLEAQITQITCAVYNHSGSEILASYSD 538
             |.|.|.::..|:||.|        ...:|.....|.:|:..:...||...::.. ||:|.||:|
plant   216 LFAVGGMEEYARLYDIRRFQGEGLNGFTRAADHFCPPHLIGNEDVGITGLAFSEQ-SELLVSYND 279

  Fly   539 AGIYLF------------------------DSRNYNRGDYLH----CYKGHINSRTIKGVNFFGP 575
            ..||||                        :|.:..:.:..|    .||||.|..|:||||||||
plant   280 EFIYLFTPGMGLGSNPIPSSPISKSPVSKSESSSSPKDENEHSVSLVYKGHKNCETVKGVNFFGP 344

  Fly   576 RSEYIVSGSDCGNIFFWDKNTEAIINYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGP 640
            ||||:|||||||.||.|.|....:|..|:.|. .||||:||||.:||||:||:|.|:|:||.:..
plant   345 RSEYVVSGSDCGRIFIWRKKGGELIRVMEADR-HVVNCIEPHPHIPVLASSGIESDIKVWTSKAA 408

  Fly   641 ER-KLPEDLLKQTLQRNFRCNIVESIDLDINNFQYFIRGFLQGSGASHLRQRHTSSLGHQMRDN- 703
            || .|||::  :.|...||...:..:.....:.:.|..|...|...:   :....|:.....||
plant   409 ERATLPENI--ELLPSRFRIPWLSFLSFHDYDDELFGNGMDIGIDGN---EGEDESIDDDAEDND 468

  Fly   704 -SSSRSNGSNASNPTSHRRNSNSSDDTNDEGADADAALD 741
             .|..|:|.:..:..|.....:..||.:|..:|.:..::
plant   469 DDSDYSSGVDLDDNDSDDDMDSDDDDVDDMDSDDECFIE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	140/375 (37%)
		WD40	318..635	CDD:295369	133/355 (37%)
		WD40 repeat	331..367	CDD:293791	14/35 (40%)
		WD40 repeat	373..414	CDD:293791	14/40 (35%)
		WD40 repeat	419..462	CDD:293791	15/42 (36%)
		WD40 repeat	472..513	CDD:293791	12/49 (24%)
		WD40 repeat	520..559	CDD:293791	14/66 (21%)
		WD40 repeat	567..594	CDD:293791	22/26 (85%)
		WD40 repeat	611..657	CDD:293791	24/46 (52%)
AT4G35140	NP_001329237.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I2228
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I1067
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		otm3432
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830