DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8001 and AT3G45620

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001190014.1	Gene:	AT3G45620 / 823704	AraportID:	AT3G45620	Length:	515	Species:	Arabidopsis thaliana

Alignment Length:	549	Identity:	178/549 - (32%)
Similarity:	257/549 - (46%)	Gaps:	115/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 TEVENLQDEVEFNEDINPADR------EKVDYAVNQVMCKCKPKYTWNYDQELLQREHNIINRID 291
            ||:.|  .|:.|:..|..:.|      ..:|.:|.:..|     |..:....:|::...|...|.
plant    16 TEIFN--REIGFSHPITISRRISASEFRIMDLSVPKTKC-----YGLSVFCRMLRKSEPIQRLIS 73

  Fly   292 WRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWDWA 356
            .|                   |:::.|...||.|.||||::.||..||::.|||||..|::|:|.
plant    74 GR-------------------VKKLDLYGKLNGHEGCVNAVEFNSTGDVLVSGSDDRQIMLWNWL 119

  Fly   357 KEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVHK 421
            ...:...:.|||..|:||||||.......|::|..|||||...|..:|.| :..||..|...|:|
plant   120 SGSRKLSYPSGHCENVFQTKFIPFTDDRTIITSGADGQVRLGQILENGKV-ETKRLGRHHGRVYK 183

  Fly   422 IIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERG--------RVRLFSIAHHP 478
            :.|:|...:...|.|||..|:|||:| ||:||.::   |:....:|        |:||.|||..|
plant   184 LAVLPGDPNVFYSCGEDGFVQHFDIR-SNSATMVL---YSSPFTQGCRRHHSSSRIRLNSIAIDP 244

  Fly   479 YAPEF-CVSGSDDILRVYDKRNLAKA-----------IHQMAPRNLLEAQITQITCAVYNHSGSE 531
            ....: .|.|||:..||||.|.:..|           ::...||:|.|.....||...|:.:| |
plant   245 RNSYYLAVGGSDEYARVYDTRRVQLAPVCRHVLPDAPVNTFCPRHLRETNSVHITGLAYSKAG-E 308

  Fly   532 ILASYSDAGIYLFDSRNYNRG--------------DYLHCYKGHINSRTIKGVNFFGPRSEYIVS 582
            :|.||:|..||||: :|...|              :....|.||.|::|:||||||||..||:.|
plant   309 LLVSYNDELIYLFE-KNMGYGSSPVSVSPEKLQEMEEPQVYIGHRNAQTVKGVNFFGPNDEYVTS 372

  Fly   583 GSDCGNIFFWDKNTEAIINYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPE-RKLPE 646
            |||||:||.|.|....::..|.||. .|||.||.||.:|:||:.|:|..||:|||...: ..|||
plant   373 GSDCGHIFIWKKKGGKLVRAMVGDR-RVVNQLESHPHIPLLASCGIEKSVKLWTPMSNDVLSLPE 436

  Fly   647 DLLK----QTLQRNFRCNIVESIDLDINNFQYFIRGFLQGSGASHLRQRHTSSLGHQMRDNSSSR 707
            .:.|    ..:.|..:..:..:.|:    ..:.:|          |::|.||:.
plant   437 KIDKVMELNRVGREDQSRVTLTPDV----IMHVLR----------LQRRQTSAF----------- 476

  Fly   708 SNGSNASNPTSHRRNSNSSDDTNDEGADA 736
                       ..|...|:|..:|||.||
plant   477 -----------TERRYVSTDIGSDEGNDA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	147/374 (39%)
		WD40	318..635	CDD:295369	140/350 (40%)
		WD40 repeat	331..367	CDD:293791	12/35 (34%)
		WD40 repeat	373..414	CDD:293791	18/40 (45%)
		WD40 repeat	419..462	CDD:293791	18/42 (43%)
		WD40 repeat	472..513	CDD:293791	16/52 (31%)
		WD40 repeat	520..559	CDD:293791	15/52 (29%)
		WD40 repeat	567..594	CDD:293791	19/26 (73%)
		WD40 repeat	611..657	CDD:293791	21/50 (42%)
AT3G45620	NP_001190014.1	WD40	81..424	CDD:295369	140/350 (40%)
		WD40	<81..424	CDD:225201	140/350 (40%)
		WD40 repeat	94..130	CDD:293791	12/35 (34%)
		WD40 repeat	136..176	CDD:293791	18/40 (45%)
		WD40 repeat	181..228	CDD:293791	19/50 (38%)
		WD40 repeat	238..291	CDD:293791	16/52 (31%)
		WD40 repeat	298..349	CDD:293791	15/52 (29%)
		WD40 repeat	400..424	CDD:293791	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	104	1.000	Domainoid score	I2228
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I1067
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		otm3432
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	O	PTHR15574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830