DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and dcaf6

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_012819655.1	Gene:	dcaf6 / 733780	XenbaseID:	XB-GENE-5738809	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	829	Identity:	152/829 - (18%)
Similarity:	236/829 - (28%)	Gaps:	418/829 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 MCKCKPKYTWNYDQELLQREHNIINRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGC 328
            |.:|.....|:..:..|              |.:........|.|.|:.|:::.|.::||:|.||
Frog     1 MSRCYSGLIWDVRKRSL--------------GLSEPDVVRSNYLGRREFVQRLKLEATLNIHDGC 51

  Fly   329 VNSLNFNRAGDLICSGSDDLTIVVWDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDG 393
            |||:::...|:.|.|||||.|:|:.:...:|.|.|.||||..|||..||:.......|:|.|.||
Frog    52 VNSISWGSTGEYILSGSDDTTLVITNPYNKKVLTRIRSGHRANIFSAKFLPLTNDKQIISCSGDG 116

  Fly   394 QVRRSVIPPSGGVIKPIRLYTHSESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAAT----- 453
            .:..:.|.......:..:...|..:.::|:.||:..:..:|.|||..|:.||.|...:.|
Frog   117 VIFFTDIEKDADTNRQCQFTCHYGTAYEIMTVPNDPYTFLSCGEDGTVRWFDTRTKTSCTKEDCK 181

  Fly   454 --TMMRCVYNDENERGRVRLFSIAHHPYAPEFCVSG-SDDILRVYDKRNL-AKAIHQMAPR---- 510
              .::.|         |....|||..|.||.:...| ||..:|:||:|.| .:|.:..:.|
Frog   182 DDILINC---------RRAATSIAICPTAPYYLAVGCSDSSVRIYDRRMLGTRATNNYSNRGTTG 237

  Fly   511 ---NLLEAQITQITCAV----YNHSGSEILASYSDAGIYLFDSRNYN------------------ 550
               ..:.:.:|..:|.|    |:..|.|:|.|||...|||||.:|..
Frog   238 MCVRFVPSHLTNKSCRVTSLCYSEDGQEVLVSYSSDYIYLFDPKNDQAKELKLPSSDQKREEVRQ 302

  Fly   551 --------RGDY----------------------------------------------------- 554
                    |||:
Frog   303 PPVKRLRLRGDWSDTGPRARPESERERDGDQSTNASLMQRMSDMLSRWFEEASEVAQSSRRRNRL 367

  Fly   555 ----------------------------------------------------------------- 554

Frog   368 QNRAGTSQPISSASLSTSHTETQASETFPEVAASSEQPSSSSNVEESHSMTSIATEQLETFASSD 432

  Fly   555 ------------------------------------------LH--------------------- 556
                                                      ||
Frog   433 GGSNPADSPSVISKQLGSMSLDEPQERAKVTSEREKNEPVLQLHYSTEGTTTSTIKLDFTDEWSN 497

  Fly   557 -----------------------------------------C----------------------- 557
                                                     |
Frog   498 RSSSSVAVKVGNNESTATTELTQPSEMEDTSESTEQHVETTCSDPGMEQESPGKSNRSSNNEGLP 562

  Fly   558 ----------------------------------------------------------------- 557

Frog   563 DTSVTAATSVSSTHQETDSDDDTVRVPSRTQSQNRLSVGGPSVSTRLTRRTAAARIQELFRRRKE 627

  Fly   558 --------------------YKGHINSRT-IKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIIN 601
                                ||||.|||| ||...|:|  ..:::||||||:||.||::|...:.
Frog   628 RKELEEMDMQNVHQPSSKIVYKGHRNSRTMIKEAAFWG--KNFVMSGSDCGHIFIWDRHTANHLM 690

  Fly   602 YMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDLLKQTLQRNFRCNIVESID 666
            .::.|: .|||||:|||:.|:||:||:::::|||:|...::.....|.::.:.||         :
Frog   691 LLEADN-HVVNCLQPHPYDPILASSGIDYNIKIWSPLEQDKCFNWRLAEEVISRN---------E 745

  Fly   667 LDINNFQYFIRGFLQGSGASHLRQRHTSSLGHQMRDNSSSRSNGSNASN 715
            |.:...:..|      :..:....|..:||.|...|....|..|:...|
Frog   746 LMLEETRNTI------TVPASFMLRMLASLNHIRADRGEDRPEGAGQDN 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	131/712 (18%)
		WD40	318..635	CDD:295369	127/693 (18%)
		WD40 repeat	331..367	CDD:293791	14/35 (40%)
		WD40 repeat	373..414	CDD:293791	9/40 (23%)
		WD40 repeat	419..462	CDD:293791	13/49 (27%)
		WD40 repeat	472..513	CDD:293791	16/49 (33%)
		WD40 repeat	520..559	CDD:293791	21/398 (5%)
		WD40 repeat	567..594	CDD:293791	13/26 (50%)
		WD40 repeat	611..657	CDD:293791	18/45 (40%)
dcaf6	XP_012819655.1	WD40	41..>284	CDD:392136	83/251 (33%)
		WD40 repeat	53..90	CDD:293791	15/36 (42%)
		WD40 repeat	95..136	CDD:293791	10/40 (25%)
		WD40 repeat	146..179	CDD:293791	11/32 (34%)
		WD40 repeat	186..229	CDD:293791	17/51 (33%)
		WD40	<665..724	CDD:392136	28/61 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010