DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and dcaf8

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001016610.1	Gene:	dcaf8 / 549364	XenbaseID:	XB-GENE-989771	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	223/657 - (33%)
Similarity:	339/657 - (51%)	Gaps:	118/657 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SDEPDASTGVIEPSDSEDYPPTSPTPIEASEAVSSPRFNPRNIPPTRSYRRISIELVGSYSDTSD 182
            |..|:..:|..|..::     :|...:|||:                    :|:.|.|..:.|:.
Frog    20 SSSPEDMSGAEEGKEN-----SSGIEVEASD--------------------VSLSLTGDETGTTQ 59

  Fly   183 SEEHELEEGTEHAEEYSDDAPEPHIAESADDSSSNDDMGPYSLS----------SEDETTTEVEN 237
            :|..:....|...::               ||.|.||.|.||::          ||||...|.|.
Frog    60 AESRDTCSETSGEDK---------------DSDSMDDTGHYSINDENRGNDQSHSEDEEEEEEEE 109

  Fly   238 LQDEVE-------------FNEDINPADREKV--DYAVNQVMCKCKPKYTWNYDQELLQREHNII 287
            ..:|.|             .|.|.:.:|.|:.  |:.:::.....:|:  |...:.|.||:..
Frog   110 EDEEEEEAVRHRKRAQRKRANRDQDSSDEERALEDWVLSEKTPLPRPR--WRALRALRQRQMG-- 170

  Fly   288 NRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVV 352
                      |::.|.....|:|..|::..||..|:.|.||||:|:||:.|..:.||||||.:||
Frog   171 ----------SSTRFIYDACGARGFVQRFRLLHGLDGHSGCVNTLHFNQRGTWLASGSDDLKVVV 225

  Fly   353 WDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSE 417
            |||.:.|.:..|.|||..|:||.||:.::|...:...:||||||.:.:..:.......|:..|..
Frog   226 WDWVRRKPVLEFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAELSATHCCKNTKRVAQHKG 290

  Fly   418 SVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSIAHHP---Y 479
            :.||:.:...|....:||||||.|...|||....|:   |.|...|.|: :|.|::|..:|   |
Frog   291 ASHKLALERDSPCTFLSAGEDAVVFTIDLRQDRPAS---RLVVTKEKEK-KVGLYTIYVNPANTY 351

  Fly   480 APEFCVSGSDDILRVYDKRNLAKAIH-----QMAPRNLLEAQI-TQITCAVYNHSGSEILASYSD 538
              :|.|.|.|..:|:||:|.:.:.::     :..|.:|:.::. ..|||.||:|.|||:||||:|
Frog   352 --QFAVGGRDQFVRIYDQRKINENVNNGVLKKFCPHHLVTSEAKANITCLVYSHDGSELLASYND 414

  Fly   539 AGIYLFDSRNYNRGDYLHCYKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIINYM 603
            ..||||:|.:.:..:|:..||||.|:.|:|||||:|||||::|||||||:||.|:|::..|:.:|
Frog   415 EDIYLFNSSHSDGAEYIKRYKGHRNNATVKGVNFYGPRSEFVVSGSDCGHIFLWEKSSCQIVQFM 479

  Fly   604 KGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDL--LKQTLQRNFRCNIVESI- 665
            .||..||||||||||.:||||||||::|||||.|...|   |.:|  ||:.:::|.|....:|:
Frog   480 DGDKGGVVNCLEPHPHLPVLATSGLDYDVKIWLPTAKE---PTELNGLKEVIKKNKRERDEDSLH 541

  Fly   666 --DLDINNFQYFIRGFLQGSGASHLRQRHTSSLGHQMRDNSSSRSNGSNASNPTSHRRNSNSSDD 728
              ||..|:..:|:        ..|||||   ....:.||......:..:..:|:|    |:||||
Frog   542 HTDLFDNHMLWFL--------MHHLRQR---GQRRRRRDAGLGAGDADSDDSPSS----SDSSDD 591

  Fly   729 TNDEGAD 735
             :::|.|
Frog   592 -DEDGPD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	155/346 (45%)
		WD40	318..635	CDD:295369	147/325 (45%)
		WD40 repeat	331..367	CDD:293791	17/35 (49%)
		WD40 repeat	373..414	CDD:293791	12/40 (30%)
		WD40 repeat	419..462	CDD:293791	16/42 (38%)
		WD40 repeat	472..513	CDD:293791	12/48 (25%)
		WD40 repeat	520..559	CDD:293791	20/38 (53%)
		WD40 repeat	567..594	CDD:293791	20/26 (77%)
		WD40 repeat	611..657	CDD:293791	27/47 (57%)
dcaf8	NP_001016610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..141		34/160 (21%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	39..50		4/30 (13%)
		WD40	191..511	CDD:421866	147/325 (45%)
		WD 1	197..236		21/38 (55%)
		WD40 repeat	204..240	CDD:293791	17/35 (49%)
		WD 2	240..281		14/40 (35%)
		WD40 repeat	246..287	CDD:293791	12/40 (30%)
		WD 3	287..327		15/42 (36%)
		WD40 repeat	292..333	CDD:293791	16/43 (37%)
		WD 4	335..375		14/42 (33%)
		WD40 repeat	341..389	CDD:293791	13/49 (27%)
		WD 5	391..430		19/38 (50%)
		WD40 repeat	396..435	CDD:293791	20/38 (53%)
		WD 6	438..478		24/39 (62%)
		WD40 repeat	443..480	CDD:293791	22/36 (61%)
		WD 7	482..522		27/42 (64%)
		WD40 repeat	487..511	CDD:293791	19/23 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..604		11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2456
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		otm48472
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100