DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and DCAF8

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_056541.2	Gene:	DCAF8 / 50717	HGNCID:	24891	Length:	597	Species:	Homo sapiens

Alignment Length:	655	Identity:	219/655 - (33%)
Similarity:	329/655 - (50%)	Gaps:	107/655 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SDEPDASTGVIEPSDSEDYPPTSPTPIEASEAVSSPRFNPRNIPPTRSYRRISIELVGSYSDTSD 182
            |..|:..:|..|..::     :|...:|||:                    :|:.|.|  .|...
Human    20 SSSPEEMSGAEEGRET-----SSGIEVEASD--------------------LSLSLTG--DDGGP 57

  Fly   183 SEEHELEEGTEHAEEYSDDAPEPHIAESADDSSSNDDMGPYSLSSE----DETTTEVENLQDEVE 243
            :.......||: .|...:|          .||.|.:|.|.||::.|    |.:..|.|..::|.|
Human    58 NRTSTESRGTD-TESSGED----------KDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEE 111

  Fly   244 -----------FNEDINPADREKV--DYAVNQVMCKCKPKYTWNYDQELLQREHNIINRIDWRGG 295
                       .|.|.:.:|.|:.  |:..::.....:|:  |.....|.:||..
Human   112 EQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPR--WQALPALRERELG---------- 164

  Fly   296 HTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWDWAKEKQ 360
              |::.|.....|:|..|::..|...|..|.||||:|:||:.|..:.||||||.:|||||.:.:.
Human   165 --SSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQP 227

  Fly   361 LHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVHKIIVV 425
            :..|.|||..|:||.||:.::|...:...:||||||.:.:..:.......|:..|..:.||:.:.
Human   228 VLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALE 292

  Fly   426 PHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSIAHHP-YAPEFCVSGSD 489
            |.|....:||||||.|...|||....|:   :.|...|.|: :|.|::|..:| ...:|.|.|.|
Human   293 PDSPCTFLSAGEDAVVFTIDLRQDRPAS---KLVVTKEKEK-KVGLYTIYVNPANTHQFAVGGRD 353

  Fly   490 DILRVYDKRNLAK-----AIHQMAPRNLLEAQI-TQITCAVYNHSGSEILASYSDAGIYLFDSRN 548
            ..:|:||:|.:.:     .:.:..|.:|:.::. ..|||.||:|.|:|:||||:|..||||:|.:
Human   354 QFVRIYDQRKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSH 418

  Fly   549 YNRGDYLHCYKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIINYMKGDHVGVVNC 613
            .:...|:..||||.|:.|:|||||:||:||::|||||||:||.|:|::..||.:|:||..|||||
Human   419 SDGAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNC 483

  Fly   614 LEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDLLKQTLQRNFRCNIVESI---DLDINNFQYF 675
            |||||.:||||||||:||||||.|.. |.......||..:::|.|....:|:   ||..::..:|
Human   484 LEPHPHLPVLATSGLDHDVKIWAPTA-EASTELTGLKDVIKKNKRERDEDSLHQTDLFDSHMLWF 547

  Fly   676 IRGFLQGSGASHLRQRHTSSLGHQMRDNSSSRSNGSNASNPTSHRRNSNSSDDTNDEGADADAAL 740
            :        ..|||||         |.:...|..|..|::..|.  .|.||.||:||    :...
Human   548 L--------MHHLRQR---------RHHRRWREPGVGATDADSD--ESPSSSDTSDE----EEGP 589

  Fly   741 DTLHC 745
            |.:.|
Human   590 DRVQC 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	150/342 (44%)
		WD40	318..635	CDD:295369	144/323 (45%)
		WD40 repeat	331..367	CDD:293791	16/35 (46%)
		WD40 repeat	373..414	CDD:293791	12/40 (30%)
		WD40 repeat	419..462	CDD:293791	16/42 (38%)
		WD40 repeat	472..513	CDD:293791	11/46 (24%)
		WD40 repeat	520..559	CDD:293791	19/38 (50%)
		WD40 repeat	567..594	CDD:293791	19/26 (73%)
		WD40 repeat	611..657	CDD:293791	26/45 (58%)
DCAF8	NP_056541.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..147		34/164 (21%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:22500989	39..50		4/30 (13%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22500989	114..122		0/7 (0%)
		WD40	189..506	CDD:392136	144/320 (45%)
		WD 1	191..230		20/38 (53%)
		WD40 repeat	198..234	CDD:293791	16/35 (46%)
		WD 2	234..275		14/40 (35%)
		WD40 repeat	240..281	CDD:293791	12/40 (30%)
		WD 3	281..321		16/42 (38%)
		WD40 repeat	286..327	CDD:293791	16/43 (37%)
		WD 4	329..369		13/40 (33%)
		WD40 repeat	335..383	CDD:293791	12/47 (26%)
		WD 5	385..424		18/38 (47%)
		WD40 repeat	390..429	CDD:293791	19/38 (50%)
		WD 6	432..472		24/39 (62%)
		WD40 repeat	437..474	CDD:293791	22/36 (61%)
		WD 7	476..515		27/39 (69%)
		WD40 repeat	481..505	CDD:293791	20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..597		13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146521
Domainoid	1	1.000	118	1.000	Domainoid score	I5845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		otm41264
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930