Protein Alignment CG8001 and LOC4576503

DIOPT Version :10

• Sequence 1: NP_647657.1
• Gene: CG8001 / 38224
• FlyBaseID: FBgn0035268
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: XP_557020.3
• Gene: LOC4576503 / 4576503
• VectorBaseID: AGAMI1_008408
• Length: 764
• Species: Anopheles gambiae
• Alignment Length: 734
• Identity: 229/734 - (31%)
• Similarity: 342/734 - (46%)
• Gaps: 142/734 - (19%)

  Fly     8 ASGAASACKRQKRNTDSQNDGEPE-DAAQIGEENTVAESQPLINFDTIV---------------- 55
            ||.|.:|....:..|.|::....| :|:...:|:...:.....:.:..|
Mosquito    97 ASAAPAAAANVRSRTPSRDRNAAERNASSSSDEDAAVDDAYFHHLEQSVRRLVHRNVRNLGSLRS 161

  Fly    56 THNNNGESDMEGKENQLQDESEQSE-----EHLANKVGPEELPEIEQAGSSNLAHQLSPEAASTV 115
            ...|:|:...:|..|...|::|...     :|       .|...|....:.|:|..|:|
Mosquito   162 RQRNDGDEGADGAANAAADDNEAGSGSDGGDH-------REQIRIRNQLADNIAELLAP------ 213

  Fly   116 LASDEPDASTGVIEPSDSEDYPPTSPTPIEASEAVSSPRFNPRNIPPTRSYRRISIELVGSYSDT 180
                      |.: |::.| |  .:|:.::::||                             |.
Mosquito   214 ----------GFL-PNELE-Y--ETPSEVDSAEA-----------------------------DL 235

  Fly   181 SDSEEHE-----LEE-----GTEHAEEYSDDAPEPHIAESADDSSSNDDMGPYSLSSEDETTTEV 235
            .|.|::.     |:.     |.|.....|.|:....::.::..|||.|....|..|||
Mosquito   236 YDDEDNNWPAGGLQRRRRLFGMEEVNHLSSDSSRSSLSSASTASSSTDGSESYIQSSE------- 293

  Fly   236 ENLQDEVEFNEDINPADREKVDYAVNQVMC------KCKPKYTWNYDQELLQREHNI-INRIDWR 293
               .|.|...|   |:|  :.|..|:.:.|      |||    ||..:|:.||:|.| .:|....
Mosquito   294 ---SDFVSIQE---PSD--QCDENVHNLECLQTSSVKCK----WNIVREISQRQHGIAFHRPPAT 346

  Fly   294 GGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWDWAKE 358
            .|..:...|....|||..:|:::.||..|..|.||||||||:.:|.|:.||||||.|.:|.|..:
Mosquito   347 VGRYNPIQFQTRAYGSVHLVQRLGLLHKLAHHTGCVNSLNFHPSGKLLASGSDDLRINLWHWESK 411

  Fly   359 KQLHRFRSGHNMNIFQTKFIDSAGC---LDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVH 420
            |.|...||||..|:|||||:...|.   ::|:|:.|||.||.:.:...|..:..: ::.....:|
Mosquito   412 KLLKSIRSGHKNNVFQTKFMTCDGYGSEIEIISTGRDGHVRHTTVKSCGQAVTKV-IFRSQHPIH 475

  Fly   421 KIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSIAHHPYAPEFCV 485
            |:.:...:....:.||||..|:..|:|.:...|.:         :.| :||:|||.|||..||||
Mosquito   476 KVAIPARNDLTFLMAGEDEKVRLCDMRQAKMQTVV---------DVG-LRLYSIATHPYDTEFCV 530

  Fly   486 SGSDDILRVYDKRNLAKAIHQMAPRNLLEA--QITQITCAVYNHSGSEILASYSDAGIYLFDSRN 548
            |||...:||||.|...|.:..:......|.  ..:.||||||||.|:||||||||..||||....
Mosquito   531 SGSGSAVRVYDLRRAQKPLRMLFVGEQGEGLRSYSSITCAVYNHDGTEILASYSDDDIYLFKLAE 595

  Fly   549 YNRGDYL--HCYKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIINYMKGDHVGVV 611
            ......:  ..::||.|.:|||||:|||||||::|||||||.::.|:|::..|:|:::.:...||
Mosquito   596 AEAEMVIPTERFRGHCNVQTIKGVSFFGPRSEFVVSGSDCGYVYIWEKSSRRIVNWLRSNPGEVV 660

  Fly   612 NCLEPHPWMPVLATSGLEHDVKIWTPQG--PERKLP----EDLLKQTLQRNFRCNIVESIDLDI- 669
            |||||||..|:|||||:::|:|:|.|:|  .|:..|    .| ||:.::||.........|..|
Mosquito   661 NCLEPHPAFPILATSGVDNDIKVWVPKGLRDEQTAPVFEWND-LKRYVRRNVHSRTQHRNDFSIR 724

  Fly   670 --NNFQYFIRGFLQGSGAS 686
              :|.......|..|..||
Mosquito   725 SASNLSRIFPAFAYGPRAS 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_647657.1	WD40	318..635	CDD:475233	141/323 (44%)
		WD40 repeat	331..367	CDD:293791	18/35 (51%)
		WD40 repeat	373..414	CDD:293791	14/43 (33%)
		WD40 repeat	419..462	CDD:293791	10/42 (24%)
		WD40 repeat	472..513	CDD:293791	19/40 (48%)
		WD40 repeat	520..559	CDD:293791	21/40 (53%)
		WD40 repeat	567..594	CDD:293791	19/26 (73%)
		WD40 repeat	611..657	CDD:293791	25/51 (49%)
LOC4576503	XP_557020.3	WD40	<366..684	CDD:441893	142/328 (43%)
		WD40 repeat	384..420	CDD:293791	18/35 (51%)
		WD40 repeat	426..468	CDD:293791	14/42 (33%)
		WD40 repeat	473..511	CDD:293791	10/46 (22%)
		WD40 repeat	517..554	CDD:293791	19/36 (53%)
		WD40 repeat	567..608	CDD:293791	21/40 (53%)
		WD40 repeat	616..653	CDD:293791	22/36 (61%)
		WD40 repeat	660..684	CDD:293791	16/23 (70%)