DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and DCAF8L2

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001340377.1	Gene:	DCAF8L2 / 347442	HGNCID:	31811	Length:	631	Species:	Homo sapiens

Alignment Length:	727	Identity:	223/727 - (30%)
Similarity:	346/727 - (47%)	Gaps:	144/727 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SDMEGKENQLQDESEQSEEHLANKVGPEEL---PEIEQAGSSNLAHQLSPEAASTV-LASDEPDA 123
            |..||..:.|.|            :|.|.|   || ||:|:     ..:.||:|.: :|:.|...
Human     2 SHQEGSTDGLPD------------LGTESLFSSPE-EQSGA-----VAATEASSDIDIATSELSV 48

  Fly   124 S-TGVIEPSDSED--YPPTSPTPIEASEAVSSPRFNPRNIPPTRSYRRISIE------------- 172
            : ||  :.|||.|  :|..:.|...:|:..|:          :......|:|
Human    49 TVTG--DGSDSRDGGFPNDASTENRSSDQESA----------SEDIELESLEDFEHFLMSGESLF 101

  Fly   173 ---LVGSYSDTSDSEEHEL-EEGTEHAEEYSDDAPEPHIAESADDSSSNDDMGPYSLSSEDE--T 231
               |||......:.|:.|: |||.|..||..::..|..  |..::.......||.......|  :
Human   102 HYPLVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEE--EEEEEEEEQPRAGPQGSGGNHEQYS 164

  Fly   232 TTEVENLQDEVEFNEDINPADREKVDYAVNQVMCKCKPKYTWNYDQELLQREHNIINRIDWRGGH 296
            ..|.:.|::.|.......|..|.:|..|::|.....:|::.:.
Human   165 LEEDQALEEWVSSETSALPRPRWQVVTALHQRQLGSRPRFVYE---------------------- 207

  Fly   297 TSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWDWAKEKQL 361
                     ..|:|..|::..|...|..|.||||:::||:.|..:.|..|||.::||||.:::.:
Human   208 ---------ACGARAFVQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPV 263

  Fly   362 HRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVHKIIVVP 426
            ..|.|||..|:||.||:.:.|...:...:||||||.:.:..:........:..|....||:.:.|
Human   264 LNFESGHTNNVFQAKFLPNCGDSTLAMCARDGQVRVAELINASYFNNTKCVAQHRGPAHKLALEP 328

  Fly   427 HSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSIAHHP---YAPEFCVSGS 488
            .|.::.:::||||.|...|||....|:   :.|...||:: :|.|::|..:|   |  :|.|.|.
Human   329 DSPYKFLTSGEDAVVFTIDLRQDRPAS---KVVVTRENDK-KVGLYTITVNPANTY--QFAVGGQ 387

  Fly   489 DDILRVYDKRNLAK-----AIHQMAPRNLLEAQI-TQITCAVYNHSGSEILASYSDAGIYLFDSR 547
            |..:|:||:|.:.|     .:.:..|.:|:.... |.|||.||:|.|:|:||||:|..||||:|.
Human   388 DQFVRIYDQRKIDKKENNGVLKKFTPHHLVNCDFPTNITCVVYSHDGTELLASYNDDDIYLFNSS 452

  Fly   548 NYNRGDYLHCYKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIINYMKGDHVGVVN 612
            :.:...|...:|||.|:.|:|||||:|||||::|||||||:||||:|::..||.::||...|.:|
Human   453 HSDGAQYSKRFKGHRNNTTVKGVNFYGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTIN 517

  Fly   613 CLEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDL--LKQTLQRNFRCNIVESIDLDINN---- 671
            ||||||::||||.|||:||||||||..   |...:|  ||:.:::|       ..:.|.::
Human   518 CLEPHPYLPVLACSGLDHDVKIWTPTA---KAATELTGLKKVIKKN-------KWERDEDSLHHG 572

  Fly   672 --FQYFIRGFLQGSGASHLRQRHTSSLG-HQMRDNSSSRSNGSNASNPTSHRRNSNSSDDTNDEG 733
              |..::..||         .||.:..| ||     ..||  ..|..|......|:|:.:|::|.
Human   573 SLFDQYMLWFL---------LRHVTQRGRHQ-----DWRS--GEAEFPDEESDESSSTSETSEEE 621

  Fly   734 ADADAALDTLHC 745
            ..     |.:.|
Human   622 VQ-----DRVQC 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	145/346 (42%)
		WD40	318..635	CDD:295369	137/325 (42%)
		WD40 repeat	331..367	CDD:293791	12/35 (34%)
		WD40 repeat	373..414	CDD:293791	11/40 (28%)
		WD40 repeat	419..462	CDD:293791	14/42 (33%)
		WD40 repeat	472..513	CDD:293791	13/48 (27%)
		WD40 repeat	520..559	CDD:293791	19/38 (50%)
		WD40 repeat	567..594	CDD:293791	21/26 (81%)
		WD40 repeat	611..657	CDD:293791	26/47 (55%)
DCAF8L2	NP_001340377.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		30/118 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..163		13/56 (23%)
		WD40	224..540	CDD:330360	136/321 (42%)
		WD 1	226..265		16/38 (42%)
		WD40 repeat	233..269	CDD:293791	12/35 (34%)
		WD 2	269..310		14/40 (35%)
		WD40 repeat	275..316	CDD:293791	11/40 (28%)
		WD 3	316..356		14/42 (33%)
		WD40 repeat	321..362	CDD:293791	14/43 (33%)
		WD 4	364..404		14/42 (33%)
		WD40 repeat	370..418	CDD:293791	14/49 (29%)
		WD 5	420..459		19/38 (50%)
		WD40 repeat	425..464	CDD:293791	19/38 (50%)
		WD 6	467..507		26/39 (67%)
		WD40 repeat	472..509	CDD:293791	24/36 (67%)
		WD 7	511..550		24/41 (59%)
		WD40 repeat	516..540	CDD:293791	18/23 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..631		11/47 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146522
Domainoid	1	1.000	118	1.000	Domainoid score	I5845
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		otm41264
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	O	PTHR15574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760