Protein Alignment CG8001 and Wdtc1

DIOPT Version :10

• Sequence 1: NP_647657.1
• Gene: CG8001 / 38224
• FlyBaseID: FBgn0035268
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: NP_001101378.1
• Gene: Wdtc1 / 313020
• RGDID: 1310362
• Length: 676
• Species: Rattus norvegicus
• Alignment Length: 679
• Identity: 151/679 - (22%)
• Similarity: 231/679 - (34%)
• Gaps: 288/679 - (42%)

  Fly   274 NYDQELLQREHNIINRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAG 338
            |..::|::|:      |..||    |.||.:.|:.:...:.::.|.:.|..|.||||.|.:|..|
  Rat     5 NITRDLIRRQ------IKERG----ALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKG 59

  Fly   339 DLICSGSDDLTIVVWDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPS 403
            ||:.|||||...:|||....|:|....:||..|||..||:..||...:::.:.|.:|....:.
  Rat    60 DLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLT-- 122

  Fly   404 GGVIKPIRLY-THSESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMM----------- 456
              |.:.|.:: .|:..|.:|...|...:...||.||..::.:|||.::..:.::
  Rat   123 --VKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGPMV 185

  Fly   457 -----------------------------RCVYN------------------------------- 461
                                         |.::|
  Rat   186 EAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYY 250

  Fly   462 ----------DENERGR------------------------VRLFSIAH--HPYA---------- 480
                      |.|.|.|                        |.||.:.:  .||.
  Rat   251 VAGHLPVKLPDYNSRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSV 315

  Fly   481 -----------------------------PEF--CVSGSDDI----------------------- 491
                                         ||.  |:|...::
  Rat   316 EVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESKGCISPQVELPPYLERVKQQANEAFACQQWTQA 380

  Fly   492 LRVYDK--------------------------------RNLAKAI---------HQMAPRNLLEA 515
            :::|.|                                |:..|||         |....|.|.|.
  Rat   381 IQLYSKAVQKAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFEL 445

  Fly   516 QIT----------------------------QITCAVYNHS-GSEILASYSDAGIYL-------- 543
            :..                            .||.|:::.| |.|..|:.....:.|
  Rat   446 KYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKSDGEEKKAAGGGGPVRLRSTSRKDS 510

  Fly   544 -------FDSRNYNRGDYLHCYKGHINSRT-IKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAII 600
                   ...|:|   ||...|.||.|:.| ||..||||..::|||||||.|:.|.|:|.|..::
  Rat   511 ISEDEMVLRERSY---DYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLV 572

  Fly   601 NYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPER-----KLPEDL--LKQTLQRNFR 658
            ..::||. .:||||:|||....|||||::..|::|.|: ||.     ::.||:  ..|..||...
  Rat   573 RVLQGDE-SIVNCLQPHPSYCFLATSGIDPVVRLWNPR-PESEDLTGRVVEDMEGASQANQRRMN 635

  Fly   659 CNIVESIDLDINNFQYFIRGFLQ-GSGAS 686
            .|.:|::.||:.   |.|.|... |:|||
  Rat   636 ANPLEAMLLDMG---YRITGLSSGGAGAS 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_647657.1	WD40	318..635	CDD:475233	121/574 (21%)
		WD40 repeat	331..367	CDD:293791	15/35 (43%)
		WD40 repeat	373..414	CDD:293791	9/41 (22%)
		WD40 repeat	419..462	CDD:293791	12/123 (10%)
		WD40 repeat	472..513	CDD:293791	15/147 (10%)
		WD40 repeat	520..559	CDD:293791	12/54 (22%)
		WD40 repeat	567..594	CDD:293791	16/26 (62%)
		WD40 repeat	611..657	CDD:293791	22/52 (42%)
Wdtc1	NP_001101378.1	WD40	<39..215	CDD:441893	46/179 (26%)
		WD40 repeat	51..88	CDD:293791	16/36 (44%)
		WD40 repeat	93..131	CDD:293791	10/41 (24%)
		WD40 repeat	138..178	CDD:293791	9/39 (23%)
		WD40 repeat	232..271	CDD:293791	4/38 (11%)
		Spy	358..>467	CDD:443119	10/108 (9%)
		TPR repeat	365..389	CDD:276809	2/23 (9%)
		TPR repeat	394..427	CDD:276809	4/32 (13%)
		TPR repeat	432..456	CDD:276809	4/23 (17%)
		WD40 repeat	536..576	CDD:293791	19/39 (49%)
		WD40	<545..>625	CDD:475233	35/81 (43%)