DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and iqw1

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_596313.1	Gene:	iqw1 / 2541121	PomBaseID:	SPBC609.03	Length:	809	Species:	Schizosaccharomyces pombe

Alignment Length:	826	Identity:	137/826 - (16%)
Similarity:	213/826 - (25%)	Gaps:	435/826 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 INRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIV 351
            :.::|:|.......|  :..||:...:..:.|...|..|.||||:|:::..|:.:.|||||..::
pombe     8 LRQLDYRDWFQRKIS--RDIYGNSTWLTGIDLQKELTGHTGCVNTLDWSADGEFLLSGSDDTRLI 70

  Fly   352 VWDWAKE-KQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPS--GGVIKPIRLY 413
            |||...| |..|...:||..|||..||:..:....|:|:|.|..::...:..|  ||:...:...
pombe    71 VWDVFNEYKPRHLISTGHVQNIFSAKFVPYSNNRQILSASGDKLIKLFDLDSSKEGGMDHGMETQ 135

  Fly   414 THS-----ESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCV-----YNDENERGR 468
            |..     :|| |.||...:.|..:...||...:.:|:|..:.....:.|.     ||..    |
pombe   136 TRCWSCALDSV-KNIVPCDNGHTFLVCSEDGTARQYDIREPHVCNQDLDCPSILVNYNPY----R 195

  Fly   469 VRLFSIAHHPYAP-EFCVSGSDDILRVYDKRNLAKA-----------------IHQMAPRNLLEA 515
            :.|::|...|..| .|.:.|:.....:||:|.:.|:                 :.:.:|.....:
pombe   196 INLYTITMSPSNPYYFAIGGTHPYAFLYDRRMVKKSFRDDWTMNTSPEKDCRCVRKFSPDGSCNS 260

  Fly   516 Q---ITQITCAVYNHSG-SEILASYSDAGIYLF----------------DS-------------- 546
            |   ...|||..::.:. :|:|.|::...:|||                ||
pombe   261 QGILDRYITCCQFSAANPNELLVSWNSDYVYLFHVHEDKSYTPTFNKIEDSNKKPSKPSLLQTQP 325

  Fly   547 ----------------------------------------------------------------- 546

pombe   326 LKRKNYSPWYKNNFGASTPASRVSRNPYTAAQPRKHTFYQMYENIEKFFTTENGGLYESIVSGRL 390

  Fly   547 -----------------RNYN-------------------------------------------- 550
                             .|||
pombe   391 SHFSRSIQYVKDAIYFLENYNYIPDSNGLNHSIRVSALRYWRACVSILALMDDTVSLEPNTIIQA 455

  Fly   551 ----------------------------------RGDYLHC------------------------ 557
                                              |.:::.|
pombe   456 GWGWLYDFMNWVTRYLLGISDHWALQMSPPTNVARQNFVLCDPDEPSRVLFSNPSEMIRAFARID 520

  Fly   558 ----------------------------------------------------------------- 557

pombe   521 TNDLSSVRRFFWIHKVLRGCLLLISSDIYWEQFQPWDSSTSDVTSSQRLDDENGFLTLLEPPVNY 585

  Fly   558 ----------------------------------------------------------------- 557

pombe   586 ENEVESSSGENIVSMYTGHSDLNDDDDDYQDEESYSYASDDDDESDEDSDEGPTLLSLRMKKRKA 650

  Fly   558 -------------YKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAIINYMKGDHVG 609
                         |.||.|..:||.|||:|...||::||||.|..|.|||...:|:..:.||. .
pombe   651 VEPNVPVNTHVKSYYGHCNVESIKNVNFYGQNDEYVMSGSDDGRFFIWDKLNASILAIIHGDS-E 714

  Fly   610 VVNCLEPHPWMPVLATSGLEHDVKIWT-----PQGPERKLPEDLLKQTLQRNFRCNIVESIDLDI 669
            .||.:|.||..|.||.||::..|||:.     |.|             ..||...|..:.|..:.
pombe   715 AVNVIEGHPRCPTLAVSGIDSTVKIFNTENTPPSG-------------CSRNHTSNSYKIIATNE 766

  Fly   670 NNFQYFIRGFLQGSGASHLRQRHTSSL----------GHQMRDNSS 705
            .|.|       |||..|::..|..|.|          ||::.|..:
pombe   767 MNRQ-------QGSRDSYITSRMLSHLAYRAHLDDGFGHEVLDTDA 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	116/732 (16%)
		WD40	318..635	CDD:295369	113/708 (16%)
		WD40 repeat	331..367	CDD:293791	13/36 (36%)
		WD40 repeat	373..414	CDD:293791	10/42 (24%)
		WD40 repeat	419..462	CDD:293791	11/47 (23%)
		WD40 repeat	472..513	CDD:293791	10/58 (17%)
		WD40 repeat	520..559	CDD:293791	16/396 (4%)
		WD40 repeat	567..594	CDD:293791	15/26 (58%)
		WD40 repeat	611..657	CDD:293791	16/50 (32%)
iqw1	NP_596313.1	WD40	32..>173	CDD:295369	44/141 (31%)
		WD40	<39..226	CDD:225201	56/191 (29%)
		WD40 repeat	49..87	CDD:293791	14/37 (38%)
		WD40 repeat	92..133	CDD:293791	11/40 (28%)
		WD40 repeat	139..183	CDD:293791	10/44 (23%)
		WD40 repeat	196..230	CDD:293791	9/33 (27%)
		WD40	<637..>761	CDD:225201	42/137 (31%)
		WD40	<659..741	CDD:295369	37/82 (45%)
		WD40 repeat	679..711	CDD:293791	13/31 (42%)
		WD40 repeat	716..742	CDD:293791	13/25 (52%)
		WD40 repeat	751..793	CDD:293791	13/48 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.900