DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and Wdtc1

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_955010.1	Gene:	Wdtc1 / 230796	MGIID:	2685541	Length:	677	Species:	Mus musculus

Alignment Length:	680	Identity:	151/680 - (22%)
Similarity:	229/680 - (33%)	Gaps:	289/680 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 NYDQELLQREHNIINRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAG 338
            |..::|::|:      :..||    |.||.:.|:.:...:.::.|.:.|..|.||||.|.:|..|
Mouse     5 NITRDLIRRQ------VKERG----ALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKG 59

  Fly   339 DLICSGSDDLTIVVWDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPS 403
            ||:.|||||...:|||....|:|....:||..|||..||:..||...:::.:.|.:|....:.
Mouse    60 DLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLT-- 122

  Fly   404 GGVIKPIRLY-THSESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMM----------- 456
              |.:.|.:: .|:..|.:|...|...:...||.||..::.:|||.::..:.::
Mouse   123 --VKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGPMV 185

  Fly   457 -----------------------------RCVYN------------------------------- 461
                                         |.::|
Mouse   186 EAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMRQSPSAGVHTFCDRQKPLPDGAAQYY 250

  Fly   462 ----------DENERGR------------------------VRLFSIAH--HPYA---------- 480
                      |.|.|.|                        |.||.:.:  .||.
Mouse   251 VAGHLPVKLPDYNSRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSV 315

  Fly   481 -----------------------------PEF--CVSGSDD----ILRVYDKRNLAKAIH----- 505
                                         ||.  |:|...:    :.||..:.|.|.|..
Mouse   316 EVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESKGCISPQVELPPYLERVKQQANEAFACQQWTQA 380

  Fly   506 --------QMAPRNLL------------------------------------------------- 513
                    |.||.|.:
Mouse   381 IQLYSQAVQKAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFEL 445

  Fly   514 --------------------------EAQITQITCAVYNHS-GSEILASYSDAGIYLFDS----- 546
                                      :|....||.|:::.| |.|..|:....|.....|
Mouse   446 KYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKSDGEEKKAAGGGGGPVRLRSTSRKD 510

  Fly   547 -----------RNYNRGDYLHCYKGHINSRT-IKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAI 599
                       |:|   ||...|.||.|:.| ||..||||..::|||||||.|:.|.|:|.|..:
Mouse   511 SISEDEMVLRERSY---DYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNL 572

  Fly   600 INYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPER-----KLPEDL--LKQTLQRNF 657
            :..::||. .:||||:|||....|||||::..|::|.|: ||.     ::.||:  ..|..||..
Mouse   573 VRVLQGDE-SIVNCLQPHPSYCFLATSGIDPVVRLWNPR-PESEDLTGRVVEDMEGASQANQRRM 635

  Fly   658 RCNIVESIDLDINNFQYFIRGFLQ-GSGAS 686
            ..|.:|::.||:.   |.|.|... |:|||
Mouse   636 NANPLEAMLLDMG---YRITGLSSGGAGAS 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	129/601 (21%)
		WD40	318..635	CDD:295369	122/575 (21%)
		WD40 repeat	331..367	CDD:293791	15/35 (43%)
		WD40 repeat	373..414	CDD:293791	9/41 (22%)
		WD40 repeat	419..462	CDD:293791	12/123 (10%)
		WD40 repeat	472..513	CDD:293791	16/100 (16%)
		WD40 repeat	520..559	CDD:293791	13/55 (24%)
		WD40 repeat	567..594	CDD:293791	16/26 (62%)
		WD40 repeat	611..657	CDD:293791	22/52 (42%)
Wdtc1	NP_955010.1	WD40	<34..163	CDD:392136	43/132 (33%)
		WD 1	45..84		20/38 (53%)
		WD40 repeat	51..88	CDD:293791	16/36 (44%)
		WD 2	88..129		13/44 (30%)
		WD40 repeat	93..131	CDD:293791	10/41 (24%)
		WD 3	132..172		11/39 (28%)
		WD40 repeat	138..178	CDD:293791	9/39 (23%)
		WD 4	182..222		2/39 (5%)
		WD40 repeat	232..271	CDD:293791	4/38 (11%)
		WD 5	265..305		6/39 (15%)
		TPR 1	361..394		8/32 (25%)
		TPR repeat	365..389	CDD:276809	3/23 (13%)
		PLN03088	367..>437	CDD:215568	7/69 (10%)
		TPR repeat	394..427	CDD:276809	1/32 (3%)
		TPR 2	396..431		0/34 (0%)
		TPR repeat	432..456	CDD:276809	0/23 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..509		4/19 (21%)
		WD 6	535..575		20/39 (51%)
		WD40 repeat	537..577	CDD:293791	19/39 (49%)
		WD40	<546..>626	CDD:392136	35/81 (43%)
		WD 7	578..617		19/40 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677		4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850