DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and WDTC1

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001263181.1	Gene:	WDTC1 / 23038	HGNCID:	29175	Length:	677	Species:	Homo sapiens

Alignment Length:	680	Identity:	147/680 - (21%)
Similarity:	225/680 - (33%)	Gaps:	289/680 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 NYDQELLQREHNIINRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAG 338
            |..::|::|:      |..||    |.||.:.|:.:...:.::.|.:.|..|.||||.|.:|..|
Human     5 NITRDLIRRQ------IKERG----ALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKG 59

  Fly   339 DLICSGSDDLTIVVWDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPS 403
            ||:.|||||...:|||....|:|....:||..|||..||:..||...:::.:.|.:|....:.
Human    60 DLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLT-- 122

  Fly   404 GGVIKPIRLY-THSESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMM----------- 456
              |.:.|.:: .|:..|.:|...|...:...||.||..::.:|||.::..:.::
Human   123 --VKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLV 185

  Fly   457 -----------------------------RCVYN------------------------------- 461
                                         |.::|
Human   186 EAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYY 250

  Fly   462 ----------DENERGR------------------------VRLFSIAH--HPYA---PEFCVSG 487
                      |.|.|.|                        |.||.:.:  .||.   |..|.|.
Human   251 VAGHLPVKLPDYNNRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSS 315

  Fly   488 SD--------------------------------------------------------------D 490
            .:                                                              .
Human   316 GEVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQWTQ 380

  Fly   491 ILRVYDK--------------------------------RNLAKAI---------HQMAPRNLLE 514
            .:::|.|                                |:..|||         |....|.|.|
Human   381 AIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFE 445

  Fly   515 AQIT----------------------------QITCAVYN-HSGSEILASYSDAGIYL------- 543
            .:..                            .||.|::: :.|.|.......|.:.|
Human   446 LKYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSRKD 510

  Fly   544 --------FDSRNYNRGDYLHCYKGHINSRT-IKGVNFFGPRSEYIVSGSDCGNIFFWDKNTEAI 599
                    ...|:|   ||...|.||.|:.| ||..||||..::|||||||.|:.|.|:|.|..:
Human   511 SISEDEMVLRERSY---DYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNL 572

  Fly   600 INYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDL-------LKQTLQRNF 657
            :..::||. .:||||:|||....|||||::..|::|.|: ||   .|||       ::...|.|.
Human   573 VRVLQGDE-SIVNCLQPHPSYCFLATSGIDPVVRLWNPR-PE---SEDLTGRVVEDMEGASQANQ 632

  Fly   658 RCNIVESIDLDINNFQYFIRGFLQ-GSGAS 686
            |....:.:::.:.|..|.|.|... |:|||
Human   633 RRMNADPLEVMLLNMGYRITGLSSGGAGAS 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	126/601 (21%)
		WD40	318..635	CDD:295369	119/575 (21%)
		WD40 repeat	331..367	CDD:293791	15/35 (43%)
		WD40 repeat	373..414	CDD:293791	9/41 (22%)
		WD40 repeat	419..462	CDD:293791	12/123 (10%)
		WD40 repeat	472..513	CDD:293791	14/148 (9%)
		WD40 repeat	520..559	CDD:293791	11/54 (20%)
		WD40 repeat	567..594	CDD:293791	16/26 (62%)
		WD40 repeat	611..657	CDD:293791	21/52 (40%)
WDTC1	NP_001263181.1	WD40	<34..163	CDD:421866	43/132 (33%)
		WD 1	45..84		20/38 (53%)
		WD40 repeat	51..88	CDD:293791	16/36 (44%)
		WD 2	88..129		13/44 (30%)
		WD40 repeat	93..131	CDD:293791	10/41 (24%)
		WD 3	132..172		11/39 (28%)
		WD40 repeat	138..178	CDD:293791	9/39 (23%)
		WD 4	182..222		2/39 (5%)
		WD40 repeat	232..271	CDD:293791	4/38 (11%)
		WD 5	265..305		6/39 (15%)
		TPR 1	362..395		2/32 (6%)
		TPR repeat	366..390	CDD:276809	2/23 (9%)
		PLN03088	368..>438	CDD:215568	7/69 (10%)
		TPR repeat	395..428	CDD:276809	4/32 (13%)
		TPR 2	397..432		4/34 (12%)
		TPR repeat	433..457	CDD:276809	4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..509		4/21 (19%)
		WD 6	535..575		20/39 (51%)
		WD40 repeat	537..577	CDD:293791	19/39 (49%)
		WD40	<546..>626	CDD:421866	36/84 (43%)
		WD 7	578..617		21/43 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677		4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850