DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and npp-23

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_501537.2	Gene:	npp-23 / 182462	WormBaseID:	WBGene00007493	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	367	Identity:	63/367 - (17%)
Similarity:	139/367 - (37%)	Gaps:	78/367 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 ELLQREHNIINRIDWRGGHTSAS--SFGQGYYGSRQVVEQ----------MTLLSSLNVHHGCVN 330
            |::|.....:::|.:. |.||:.  |.|:|......:.|:          .|..|.::.:..|
Worm    30 EIMQHADVKLSKILFT-GETSSQIISLGKGRGRCISLWERDDGIDPFKVLATKNSEIDPNDAC-- 91

  Fly   331 SLNFNRAGDLICSGSDDLTIVVW-----DWAKEKQLHRFRSG--------HNMNIFQTKFIDSAG 382
            ::..||    :|.|..|.::.|:     |.|...::....||        |..:|.......|..
Worm    92 TMTDNR----VCIGYADGSLAVFSTDKDDLALMSRIPSIHSGSASRKICRHGNSILSASSNGSLV 152

  Fly   383 CLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVHKIIVVPHSRHELMSAGEDAAVKHFDLR 447
            .:|:.:.     :.|::.....|:              :.:......:.:|:...:..:..:|||
Worm   153 AVDVETG-----MPRTIFTGQAGI--------------RSVCTTFGTNVVMAGDANGQITMWDLR 198

  Fly   448 ASNAATTMMRCVYN-DENERGRVRLFSIAHHPYAPEFCVSGSDD-ILRVYDKRNLAKAIHQMAPR 510
            .:|..:..:..:.. ..:::....:.::..||........|:|| |:.:.|.||: :..:..:..
Worm   199 ENNEHSNTLDPIKTLIPSKKALDAVTALCSHPAQSNLVCCGTDDGIVGLIDARNV-RGANITSTY 262

  Fly   511 NLLEAQITQITCAVYNHSGSEILASYSDAGIYLFDSRN--------------YNRGDYLHCYK-G 560
            .:.:..|:|:  ..:...|..:|.|.:|..:...|:..              :..||.::..: .
Worm   263 LVAKKAISQV--MFHPKCGDNLLVSSNDGSLIRIDASGAPIAVGPRSTKDTIWLEGDLVNSLRLD 325

  Fly   561 HINSRTIKGVNFFGPRSEYIVSGSDCGNI-------FFWDKN 595
            .|.:.::..::.|..||:.:|:.|..|.|       ||.:.|
Worm   326 PIRNESVHSISSFDIRSDTVVTASSIGLISLYQQLPFFPNSN 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	53/316 (17%)
		WD40	318..635	CDD:295369	52/315 (17%)
		WD40 repeat	331..367	CDD:293791	8/40 (20%)
		WD40 repeat	373..414	CDD:293791	4/40 (10%)
		WD40 repeat	419..462	CDD:293791	5/43 (12%)
		WD40 repeat	472..513	CDD:293791	9/41 (22%)
		WD40 repeat	520..559	CDD:293791	7/52 (13%)
		WD40 repeat	567..594	CDD:293791	9/33 (27%)
		WD40 repeat	611..657	CDD:293791
npp-23	NP_501537.2	WD40	20..357	CDD:225201	60/355 (17%)
		WD40	96..>329	CDD:295369	40/258 (16%)
		WD40 repeat	133..166	CDD:293791	5/37 (14%)
		WD40 repeat	171..208	CDD:293791	5/50 (10%)
		WD40 repeat	223..264	CDD:293791	9/41 (22%)
		WD40 repeat	269..294	CDD:293791	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000