Protein Alignment CG8001 and R11D1.1

DIOPT Version :10

• Sequence 1: NP_647657.1
• Gene: CG8001 / 38224
• FlyBaseID: FBgn0035268
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: NP_506171.2
• Gene: R11D1.1 / 179738
• WormBaseID: WBGene00011242
• Length: 622
• Species: Caenorhabditis elegans
• Alignment Length: 655
• Identity: 125/655 - (19%)
• Similarity: 221/655 - (33%)
• Gaps: 204/655 - (31%)

  Fly   246 EDINPADREKVDYAVNQVMCKCKPKYTWNYDQELLQREHNIINRIDWRGGHTSASSFGQGYYGSR 310
            |:..|.:.|.:|..:::     .....:..:..|.|||...:..:    ..|....|....:..:
 Worm     5 EEPPPENEENMDIEISK-----STNNQFKIESFLCQREIGSVKSV----VKTFRPDFQHRPFCQK 60

  Fly   311 QVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLTIVVWDWAK------EKQLHRFRSGHN 369
            .|.|          |.||:|:|.|:.....:.||.||:...||:..:      .|.:......|.
 Worm    61 DVRE----------HTGCINALQFSHNDRFLASGGDDMHGRVWNVDELMVRKTPKPIGVMEHPHR 115

  Fly   370 MNIFQTKFIDSAGCLD-----IVSSSRDGQVRRSVIPPSGGVIKPIRLYTHSESVHKIIVVPHSR 429
            .|||..:|       |     :.|..|.|.|.:..|.....:      |..:|:.::..|....:
 Worm   116 SNIFSLEF-------DLENRFLYSGERWGTVIKHDIETKQSI------YVANENNNRGDVYHMDQ 167

  Fly   430 H----ELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSIAHHPYAPEFCVSGSD- 489
            |    .|:.......|...|.|......:::....:.:|      .::...||..|...:..|:
 Worm   168 HPTDNTLIVVTRAKLVSFIDNRDRQNPISLVLPANSGKN------FYTAEFHPETPALILVNSET 226

  Fly   490 DILRVYDKRNLAKAIHQMAPRNLLEAQITQITCAVYNHSGSEILASYSDAGIYLFDSRNYN---- 550
            ....|:|:|..|:.::|.:....|..:.|:...::::.||::.::.........||..:..
 Worm   227 GGPNVFDRRMQARPVYQRSMFKGLPQENTEWMGSLWSPSGNQFMSIRRGKCPLYFDFISQRCFVL 291

  Fly   551 RGDYLHCYKGHINSRTIKGVNFFGPRSEY-IVSGSDCGNIFFW----------------DKN--- 595
            :.|  |...|:.|.:|||.:.|.   .:| :.:|||...|..|                |:.
 Worm   292 KSD--HNPNGYCNIKTIKSMTFI---DDYTVATGSDHWGIHIWKLPRANDSYGFTQIGHDEEEMP 351

  Fly   596 ----TEAIINYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWT---------------PQG-- 639
                .|..:..::| |..|.|.:.......:|.:||:|:..|:|:               |.|
 Worm   352 SEIFIEKELTVLRG-HRSVPNQVRFSQHNNLLVSSGVENSFKLWSDHRLPWSYDLPFERRPHGTY 415

  Fly   640 ------------PERKLPEDLLKQTLQRNFRC--------------------------------N 660
                        .||::.||.|....:.:.|.                                :
 Worm   416 DLSAEEECLREMEERRVVEDALDLNGEMDGRACWRDIFGGDARTAEDRDTLEMFDPRGHGDDEED 480

  Fly   661 IVES--------IDLDINNFQYFIRG--------FLQGSGASHLR---QRHTS----------SL 696
            :.||        :|.:.::..||.|.        .||.:|..||.   :.|..          ::
 Worm   481 VEESSSEDSDDMMDNEADDNHYFRRRRGPLQLFVLLQRAGEEHLARMLEEHDGVENDLLEELFNM 545

  Fly   697 GHQMRDNSS----SRSNGSNA-------SNPTSHRRNSNSS--------------DDTNDEGADA 736
            ..:.|:.||    |..:|.|.       .|..|...||:||              |:..||| |.
 Worm   546 RRRFREESSDEDDSGDDGENGDENDNENDNIESSSSNSDSSDASEVGDLMDFDGDDEEEDEG-DD 609

  Fly   737 DAALD 741
            :||::
 Worm   610 EAAIE 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_647657.1	WD40	318..635	CDD:475233	73/360 (20%)
		WD40 repeat	331..367	CDD:293791	9/41 (22%)
		WD40 repeat	373..414	CDD:293791	8/45 (18%)
		WD40 repeat	419..462	CDD:293791	6/46 (13%)
		WD40 repeat	472..513	CDD:293791	9/41 (22%)
		WD40 repeat	520..559	CDD:293791	6/42 (14%)
		WD40 repeat	567..594	CDD:293791	9/43 (21%)
		WD40 repeat	611..657	CDD:293791	14/74 (19%)
R11D1.1	NP_506171.2	WD40	58..395	CDD:475233	75/371 (20%)
		WD40 repeat	69..111	CDD:293791	10/41 (24%)
		WD40 repeat	118..152	CDD:293791	9/46 (20%)
		WD40 repeat	230..293	CDD:293791	11/62 (18%)
		WD40 repeat	306..343	CDD:293791	9/39 (23%)