DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8001 and dcaf8

DIOPT Version :9

Sequence 1:	NP_001261283.1	Gene:	CG8001 / 38224	FlyBaseID:	FBgn0035268	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_021323428.1	Gene:	dcaf8 / 100007924	ZFINID:	ZDB-GENE-070912-578	Length:	607	Species:	Danio rerio

Alignment Length:	664	Identity:	219/664 - (32%)
Similarity:	316/664 - (47%)	Gaps:	124/664 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SDEPDASTGVIEPSDSEDYPPTSPTPIEASEAVSSPRFNPRNIPPTRSYRRISIELVGSYSDTSD 182
            ||:|       ||.:......||.....| ||.:||.....|.....|       .||.....:|
Zfish    15 SDDP-------EPGEGRGEAETSDASAVA-EAQASPESANLNSAAEGS-------AVGQDKLMAD 64

  Fly   183 SEEHELEEGTEHAEEYSDDAPEPHIAESADDSSSNDDMGPYSLSSEDETTTE------------- 234
            ||:   ::|.  |||              :|:.|.|..|.|||:.|.|..:|
Zfish    65 SEQ---KQGP--AEE--------------EDTDSMDGSGLYSLTEEGERESEGGGRGKDEGKRSA 110

  Fly   235 ---------------VENLQDEVEFNEDINPADREKVDYAVNQVMCKCKPKYTWNYDQELLQREH 284
                           ..:..||.|.::|:...|.:.::..:...:|... :.:|.....|..||
Zfish   111 RKRNRPSGGAAHHSSSSDDDDENEEDDDVEEEDEQAMEAWLGADLCDLS-RPSWRAIPSLRARE- 173

  Fly   285 NIINRIDWRGGHTSASSFGQGYYGSRQVVEQMTLLSSLNVHHGCVNSLNFNRAGDLICSGSDDLT 349
              |.|        .:..|.:...|:|.:|:::.|...|..|.||||:|:||.:|..:.||||||.
Zfish   174 --IGR--------DSQQFVRKVCGARGLVQRLELQGRLERHTGCVNTLHFNPSGTRLASGSDDLR 228

  Fly   350 IVVWDWAKEKQLHRFRSGHNMNIFQTKFIDSAGCLDIVSSSRDGQVRRSVIPPSGGVIKPIRLYT 414
            :|:||||:.|....|.|||..|:||.||:..:|...:...:||||:|.:.:..:.......|:..
Zfish   229 VVIWDWARRKAELEFDSGHKSNVFQAKFLPHSGDSTLAMCARDGQIRVAELSATQRCKNTKRVAQ 293

  Fly   415 HSESVHKIIVVPHSRHELMSAGEDAAVKHFDLRASNAATTMMRCVYNDENERGRVRLFSI----- 474
            |..:.||:.:.|.|....:||||||.|...|||....|.   :.|...|.|: :|.|::|
Zfish   294 HKGAAHKLALEPDSPCSFLSAGEDAVVFGIDLRLDRPAN---KLVVVKEGEK-KVGLYTIYVNPA 354

  Fly   475 -AHHPYAPEFCVSGSDDILRVYDKRNLAK-----AIHQMAPRNLLEAQI-TQITCAVYNHSGSEI 532
             .||     |.|.|.|..:|:||:|.:.:     .:.:..|.:|:.::. |.|||.||:|.|:|:
Zfish   355 NTHH-----FAVGGRDQYVRIYDQRKINEHDNNGVLKKFCPSHLVSSESKTNITCLVYSHDGTEL 414

  Fly   533 LASYSDAGIYLFDSRNYNRGDYLHCYKGHINSRTIKGVNFFGPRSEYIVSGSDCGNIFFWDKNTE 597
            ||||:|..||||||.:.:..||...||||.|:.|:|||||:||.||::|||||||:|:.||||:.
Zfish   415 LASYNDEDIYLFDSSHSDGADYHRKYKGHRNNATVKGVNFYGPCSEFVVSGSDCGHIYLWDKNSA 479

  Fly   598 AIINYMKGDHVGVVNCLEPHPWMPVLATSGLEHDVKIWTPQGPERKLPEDL--LKQTLQRNFR-- 658
            .::.:|:||..||||||||||.:|.||||||:||||:|.|....   |..|  ||:.:::|.|
Zfish   480 RVVQFMEGDRGGVVNCLEPHPHLPGLATSGLDHDVKLWAPTAEN---PTTLKGLKEVMKKNKRER 541

  Fly   659 --CNIVESIDLDINNFQYFIRGFLQGSGASHLRQRHTSSLGHQMRDNSSSRSNGSNASNPTSHRR 721
              .|:......|.....:.:|         |:|.|         |...:.|..|....  |....
Zfish   542 DEDNVRHGDQYDTQLLWFLMR---------HMRNR---------RPQRTRRGEGGEGD--TDESW 586

  Fly   722 NSNSSDDTNDEGAD 735
            :|..|.|..|.|.|
Zfish   587 SSPESSDEEDGGPD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8001	NP_001261283.1	WD40	<317..653	CDD:225201	152/349 (44%)
		WD40	318..635	CDD:295369	146/328 (45%)
		WD40 repeat	331..367	CDD:293791	17/35 (49%)
		WD40 repeat	373..414	CDD:293791	11/40 (28%)
		WD40 repeat	419..462	CDD:293791	16/42 (38%)
		WD40 repeat	472..513	CDD:293791	12/51 (24%)
		WD40 repeat	520..559	CDD:293791	21/38 (55%)
		WD40 repeat	567..594	CDD:293791	18/26 (69%)
		WD40 repeat	611..657	CDD:293791	25/47 (53%)
dcaf8	XP_021323428.1	WD40	201..518	CDD:330360	145/325 (45%)
		WD40 repeat	210..246	CDD:293791	17/35 (49%)
		WD40 repeat	252..293	CDD:293791	11/40 (28%)
		WD40 repeat	298..339	CDD:293791	16/43 (37%)
		WD40 repeat	347..390	CDD:293791	11/47 (23%)
		WD40 repeat	402..441	CDD:293791	21/38 (55%)
		WD40 repeat	449..486	CDD:293791	21/36 (58%)
		WD40 repeat	493..517	CDD:293791	19/23 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580150
Domainoid	1	1.000	118	1.000	Domainoid score	I5846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2626
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0003170
OrthoInspector	1	1.000	-	-		oto40849
orthoMCL	1	0.900	-	-		OOG6_103613
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R616
SonicParanoid	1	1.000	-	-		X2134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930