DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht2 and Chia1

DIOPT Version :9

Sequence 1:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_075675.2	Gene:	Chia1 / 81600	MGIID:	1932052	Length:	473	Species:	Mus musculus

Alignment Length:	474	Identity:	156/474 - (32%)
Similarity:	242/474 - (51%)	Gaps:	65/474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLASTASSLWASVAARTGPLHDKVVVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLD 81
            |||:...|..|    .|:.|..::  ::||.:.||.|||..|::..::.:|.||||::|||||:.
Mouse     4 LLLVTGLALLL----NAQLGSAYN--LICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQ 62

  Fly    82 ITQAAIKSLDPWQDLKEEYGKGGYEKMTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGR 146
            ..:  |.::: |.|:..      |:....||..:..||..|||||||.|:|.::|:|:.:..|..
Mouse    63 NNE--ITTIE-WNDVTL------YKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQT 118

  Fly   147 FVKQVSSFIRKYNFDGLDLDWEYPTQRKGKPADRENFVLLTKELREEFDEHG-------LLLTSA 204
            |:..|..|:|:|.|||||||||||..|...|.|:..|.:|.||:||.|::..       |::|:|
Mouse   119 FITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAA 183

  Fly   205 IGASKKVIDEAYDVRQISRYLDYLHIMCYDYHGSWDRRVGYNAPL-TAPADDPLSVKFSIDYLLK 268
            :......|...|::.::|:|||::|:|.||.||||:...|.|:|| ..|.:...:...::||::.
Mouse   184 VAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMN 248

  Fly   269 L----GAPPEKLVMGLPFYGRTF--KTLASGFLNDVSEGVGFKGPYTREDGFLGYNEICQTLSNQ 327
            .    |||.|||::|.|.||.||  :..:...:...:.|.|..|||||:.||..|.|||..|
Mouse   249 YWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFL--- 310

  Fly   328 TSGWTREWDPQTSQVLAKSERNVFTQEINV-VTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDF 391
            .||.|..||        .|:...:..:.|. :.||:.:|.:.|..:.......|.|:|::|.|||
Mouse   311 RSGATEVWD--------ASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDF 367

  Fly   392 LGN-CKLDEDTYEDFQKVTAAPKRSSQNYPLLRTINEATMLAVDELAVPEPQPDDSENEIPHGSI 455
            .|: |                   ....:||..|:|:|..::.:....|:...:....  |.||.
Mouse   368 TGSFC-------------------DQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTT--PPGSG 411

  Fly   456 ADRKNAGASMVSLGLGVTA 474
            :...::|.|  |.|.|..|
Mouse   412 SGGGSSGGS--SGGSGFCA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	129/361 (36%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	138/400 (35%)
Chia1	NP_075675.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	138/401 (34%)
		Glyco_18	24..365	CDD:214753	129/360 (36%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		6/30 (20%)
		ChtBD2	426..473	CDD:214696	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D826687at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930