DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht2 and Cht8

DIOPT Version :9

Sequence 1:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	172/474 - (36%)
Similarity:	251/474 - (52%)	Gaps:	59/474 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSGEAPQLWLLLLLASTASSLWASVAARTGPLHDKVVVCYVSTWAVYRPEQGAYAIENFDPNLCT 71
            :||....|..::|:|:::|:...|         .|.||||..||:||||..|.:.:|:.||.|||
  Fly     4 VSGLVKLLLGVILMAASSSAQGNS---------SKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCT 59

  Fly    72 HVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEKMTGLKRSHPHLKVSLAIGGWNEGSANYST 136
            |::|||.|::.| ..::.:|.:.||:|..|:|..:....||..:|.||..:|:|||||||..:|.
  Fly    60 HLIYAFLGIEET-GQLRVIDAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSL 123

  Fly   137 LVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQRKG-KPADRENFVLLTKELREEFDEHGLL 200
            :..:...|.:||..|..|::::.|||||||||||.||.. ...||.|::...|||:|..:..|.:
  Fly   124 VARDPSKREKFVDDVVRFLQRHGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELKEGLEPFGFI 188

  Fly   201 LTSAIGASKKVIDEAYDVRQISRYLDYLHIMCYDYHGSWDRRVGYNAPLTAPADD---------P 256
            |::|:|:::...:.:||:..:..|||.:::|.||.||.||:.||.||||.|...|         .
  Fly   189 LSAAVGSAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQ 253

  Fly   257 LSVKFSIDYLLKLGAPPEKLVMGLPFYGRTFKTLASGFLNDVSE---GVGFKGPYTREDGFLGYN 318
            |:|...:.|.||.|||.|||::|:|||||:| |||:...|....   |.|..|.|:||.|.||||
  Fly   254 LNVDAVVKYWLKAGAPAEKLILGVPFYGRSF-TLATAEGNQPGAPHIGKGIAGNYSREPGVLGYN 317

  Fly   319 EICQTLSNQTSGWTREWDPQTSQVLAKSERNVFTQEINVVTYDSSRSIANKVLFAMSKRLAGVMV 383
            |:|:.:..:.  ||::|:.......|..:|       ..|.|:..||:|.|..:.|...|.|:|:
  Fly   318 ELCEMMEREE--WTQKWEATQQVPYAYRQR-------QWVGYEDPRSLALKAQYVMDNHLGGIMI 373

  Fly   384 WSVDTDDFLGNCKLDEDTYEDFQKVTAAPKRSSQNYPLLRTINEATM--LAVDELAVPEPQPDDS 446
            ||:::|||.|.|                   ..|.||||..||....  .....|.....:...|
  Fly   374 WSLESDDFRGTC-------------------GQQPYPLLHEINRVLFGGNTPSGLTTESNRESPS 419

  Fly   447 EN-----EIPHGSIADRKN 460
            |.     :.|.|.|.|..|
  Fly   420 EGFSCPADAPAGYIRDPDN 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	144/359 (40%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	156/397 (39%)
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	156/398 (39%)
		Glyco_18	31..379	CDD:214753	144/358 (40%)
		CBM_14	424..476	CDD:279884	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I1632
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48394at33392
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
	9	8.970