DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht2 and lmd-4

DIOPT Version :9

Sequence 1:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_504862.2	Gene:	lmd-4 / 179121	WormBaseID:	WBGene00017233	Length:	2011	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	111/403 - (27%)
Similarity:	189/403 - (46%)	Gaps:	75/403 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AARTGPLHDKVVVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGL----DITQAAIKSLDP 92
            ||..|    |.:|.|.:.|       |...|........|||::||..:    .:...|:..
Worm  1474 AASCG----KRIVGYYTGW-------GDREITENQLKKLTHVIFAFVAMYEDGSVKFGAVSE--- 1524

  Fly    93 WQDLKEEYGKGGYEKMTGLKR----SHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSS 153
             .|...:..|....:...:|:    ::..::|..|:||| :.|..:|::.|::..|.:||..::|
Worm  1525 -DDSGPQAAKKAERRFLNMKKKARAANSGVRVLFAVGGW-DNSQYFSSVAADSGKRKKFVDSIAS 1587

  Fly   154 FIRKYNFDGLDLDWEYPTQRKGKPADRENFVLLTKELREEFDEHG--------LLLTSAIGASKK 210
            |:.....||:||||||| ...||  |.:|.|.|.||:||:|.|..        .::|.|..|.:.
Worm  1588 FVEDQKIDGVDLDWEYP-DSNGK--DAKNHVQLIKEIREKFSEMAKKKKRKDPYVITLASAAGEW 1649

  Fly   211 VIDEAYDVRQISRYLDYLHIMCYDYHGSWDRR----VGYNAPLTAPADDPLSVKFSIDYLLKLGA 271
            .:.:.||::.|.:|.|::::|.|||:|:|:.:    .|..|||...:....|.|.:.|:.:|..|
Worm  1650 NLRKGYDLKGILKYADFINVMTYDYYGAWESKWGAYTGTPAPLYFGSLKGFSGKLNADFSMKFYA 1714

  Fly   272 ----PPEKLVMGLPFYGRTFKTLASGFLNDVSEGV-----GFKGPYTREDGFLGYNEICQTLSNQ 327
                .|.:|.||:|||||.:|.:....  |.|:.:     ...|.|  |.|::|:..:.:
Worm  1715 CKTEKPSQLNMGVPFYGRYWKNVLGPI--DKSDNMWRTAAPQNGKY--EGGYVGWRNLAK----- 1770

  Fly   328 TSGWTR---EWDPQT-SQVLAKSERNVFTQEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDT 388
             .||.:   .|..:| :..:..:....|      :.:::.||:..|:.:|..:.|.|:|:|::|.
Worm  1771 -EGWNKGSASWHEKTKTPYIMNNGAKKF------LGFENERSLKEKMKYATDRNLGGLMIWALDL 1828

  Fly   389 DDFLGNCKLDEDT 401
            ||       |.||
Worm  1829 DD-------DADT 1834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	102/379 (27%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	107/392 (27%)
lmd-4	NP_504862.2	LysM	25..65	CDD:197609
		LysM	79..120	CDD:197609
		LysM	142..185	CDD:197609
		LysM	209..250	CDD:197609
		LysM	270..313	CDD:197609
		LysM	334..377	CDD:197609
		LysM	401..444	CDD:197609
		LysM	469..509	CDD:197609
		LysM	550..590	CDD:197609
		LysM	635..678	CDD:197609
		LysM	710..750	CDD:197609
		LysM	760..802	CDD:197609
		LysM	876..919	CDD:197609
		Self-incomp_S1	1359..1433	CDD:283566
		Glyco_18	1480..1825	CDD:214753	100/375 (27%)
		GH18_chitinase-like	1481..1824	CDD:299167	100/373 (27%)
		ChtBD1_GH18_2	1873..1924	CDD:211315
		ChtBD1_GH18_2	1951..2002	CDD:211315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369121at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820