DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cht2 and Chi3l1

DIOPT Version :10

Sequence 1:NP_477298.2 Gene:Cht2 / 38223 FlyBaseID:FBgn0022702 Length:484 Species:Drosophila melanogaster
Sequence 2:NP_031721.2 Gene:Chi3l1 / 12654 MGIID:1340899 Length:389 Species:Mus musculus


Alignment Length:454 Identity:151/454 - (33%)
Similarity:226/454 - (49%) Gaps:101/454 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTLRSRLSGEAPQLWLLLLLASTASSLWASVAARTGPLHDKVVVCYVSTWAVYRPEQGAYAIENF 65
            |.:|:.|:|.|.   |:||.:.:|..|                |||.::|:.||...|::..:..
Mouse     9 MGMRAALTGFAV---LMLLQSCSAYKL----------------VCYFTSWSQYREGVGSFLPDAI 54

  Fly    66 DPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEKMTGLKRSHPHLKVSLAIGGWNEG 130
            .|.||||::|:||  :|:...:.|...|.|      :..|:|:..||..:.:||..|::|||..|
Mouse    55 QPFLCTHIIYSFA--NISSDNMLSTWEWND------ESNYDKLNKLKTRNTNLKTLLSVGGWKFG 111

  Fly   131 SANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQRKGKPADRENFVLLTKELREEFD 195
            ...:|.:.:|...|..||:.|:.|:|.|.||||||.|.||..|     |::.|..|.|||..||.
Mouse   112 EKRFSEIASNTERRTAFVRSVAPFLRSYGFDGLDLAWLYPRLR-----DKQYFSTLIKELNAEFT 171

  Fly   196 E------HGLLLTSAIGASKKVIDEAYDVRQISRYLDYLHIMCYDYHGSWDRRVGYNAPLTAPAD 254
            :      ..|||::|:.|.|..||..||:.||:::||::::|.||:||.|.:..|:::||.....
Mouse   172 KEVQPGREKLLLSAALSAGKVAIDTGYDIAQIAQHLDFINLMTYDFHGVWRQITGHHSPLFQGQK 236

  Fly   255 DP-----LSVKFSIDYLLKLGAPPEKLVMGLPFYGRTFKTLAS--GFLNDVSEGVGFKGPYTRED 312
            |.     .:|.:::.|:::|||...||:||:|.:|::| ||||  ..|.....|.|..|.:|:|.
Mouse   237 DTRFDRYSNVNYAVQYMIRLGAQASKLLMGIPTFGKSF-TLASSENQLGAPISGEGLPGRFTKEA 300

  Fly   313 GFLGYNEIC--------QTLSNQ-----TSGWTREWDPQTSQVLAKSERNVFTQEINVVTYDSSR 364
            |.|.|.|||        ..|||:     |.|  .:|                      |.|:...
Mouse   301 GTLAYYEICDFLKGAEVHRLSNEKVPFATKG--NQW----------------------VGYEDKE 341

  Fly   365 SIANKVLFAMSKRLAGVMVWSVDTDDFLGNCKLDEDTYEDFQKVTAAPKRSSQNYPLLRTINEA 428
            |:.|||.|...|:|||.|||::|.|||.|.|:               ||   :.:||...|.:|
Mouse   342 SVKNKVGFLKEKKLAGAMVWALDLDDFQGTCQ---------------PK---EFFPLTNAIKDA 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cht2NP_477298.2 GH18_chitolectin_chitotriosidase 43..428 CDD:119351 140/410 (34%)
Chi3l1NP_031721.2 GH18_chitolectin_chitotriosidase 32..388 CDD:119351 142/428 (33%)
Important for AKT1 activation and IL8 production 333..347 5/35 (14%)

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