DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht2 and Chia

DIOPT Version :9

Sequence 1:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_997469.1	Gene:	Chia / 113901	RGDID:	1303058	Length:	473	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	153/451 - (33%)
Similarity:	227/451 - (50%)	Gaps:	76/451 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEK 107
            :|||.:.||.|||..|::..::.:|.||||::|||||:...|  |.::: |.|:..      |:.
  Rat    24 LVCYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNQ--ITTIE-WNDVTL------YKA 79

  Fly   108 MTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQ 172
            ...||..:..||..|||||||.|:|.::|:|:.:..|..|:..|..|:|:|.|||||||||||..
  Rat    80 FNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGS 144

  Fly   173 RKGKPADRENFVLLTKELREEFDEHG-------LLLTSAIGASKKVIDEAYDVRQISRYLDYLHI 230
            |...|.|:..|.:|.|||||.|::..       |::|:|:.|....|...|::.::|:|||::|:
  Rat   145 RGSPPQDKHLFTVLVKELREAFEQEAIESNRPRLMVTAAVAAGISNIQAGYEIPELSQYLDFIHV 209

  Fly   231 MCYDYHGSWDRRVGYNAPL-TAPADDPLSVKFSIDYLLKL----GAPPEKLVMGLPFYGRTFKTL 290
            |.||.|||||...|.|:|| ..|.:...:...::||::..    |||.|||::|.|.||.|:
  Rat   210 MTYDLHGSWDGYTGENSPLYKLPTETGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPEYGHTY--- 271

  Fly   291 ASGFLNDVSE--------GVGFKGPYTREDGFLGYNEICQTLSNQTSGWTREWD-PQTSQVLAKS 346
               .|::.|:        |.|..|||||:.||..|.|||..|.|   |.|::|| ||......|.
  Rat   272 ---ILSNPSDTGIGAPTSGNGPAGPYTRQAGFWAYYEICTFLRN---GATQDWDAPQEVPYAYKG 330

  Fly   347 ERNVFTQEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGN-CKLDEDTYEDFQKVTA 410
            .        ..|.||:.:|.:.|..:.......|.|:|::|.|||.|: |
  Rat   331 N--------EWVGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFC--------------- 372

  Fly   411 APKRSSQNYPLLRTINEATMLAVDELAVPEPQPDDSENEIPHGSIADRKNAGASMVSLGLG 471
                ....:||..|:|:|..:.......|         ::|...:.....:|:...|.|.|
  Rat   373 ----DQGKFPLTSTLNKALDIPTAGCTAP---------DLPSEPVTTPPGSGSGGGSSGGG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	137/366 (37%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	146/406 (36%)
Chia	NP_997469.1	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	146/407 (36%)
		Glyco_18	24..365	CDD:214753	137/366 (37%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..421		6/35 (17%)
		ChtBD2	426..473	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D826687at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030