DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht2 and CHI3L2

DIOPT Version :9

Sequence 1:	NP_001246550.1	Gene:	Cht2 / 38223	FlyBaseID:	FBgn0022702	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_003991.2	Gene:	CHI3L2 / 1117	HGNCID:	1933	Length:	390	Species:	Homo sapiens

Alignment Length:	424	Identity:	140/424 - (33%)
Similarity:	220/424 - (51%)	Gaps:	68/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SLWASVAA----RTGPLHDKVVVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAA 86
            ||||.|..    :.|..:.  :|||.:.|:..|.|.|.:..||.||.||:|::|:||.::..:..
Human    10 SLWAGVVVLLLLQGGSAYK--LVCYFTNWSQDRQEPGKFTPENIDPFLCSHLIYSFASIENNKVI 72

  Fly    87 IKSLDPWQDLKEEYGKGGYEKMTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQV 151
            ||.       |.|...  |:.:..||..:|.||:.|:|||:..||..:..:|.::..|..|:..:
Human    73 IKD-------KSEVML--YQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTSRLEFINSI 128

  Fly   152 SSFIRKYNFDGLDLDWEYPTQRKGKPADRENFVLLTKELREEFD-------EHGLLLTSAIGASK 209
            ..|:|.:||||||:.|.||.|:     :..:|.:|..||.|.|.       :..||||:.:.|.:
Human   129 ILFLRNHNFDGLDVSWIYPDQK-----ENTHFTVLIHELAEAFQKDFTKSTKERLLLTAGVSAGR 188

  Fly   210 KVIDEAYDVRQISRYLDYLHIMCYDYHGSWDRRV--GYNAPLTAPADD--PLS---VKFSIDYLL 267
            ::||.:|.|.::::.||:::::.:|:||||::.:  |:|:||:....|  |.|   |::::.|.:
Human   189 QMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSSYYNVEYAVGYWI 253

  Fly   268 KLGAPPEKLVMGLPFYGRTFKTLASG--FLNDVSEGVGFKGPYTREDGFLGYNEICQTLSNQTSG 330
            ..|.|.||:|||:|.||.:| ||||.  .:...:.|.|..||.|...|||.|.||||.|..  :.
Human   254 HKGMPSEKVVMGIPTYGHSF-TLASAETTVGAPASGPGAAGPITESSGFLAYYEICQFLKG--AK 315

  Fly   331 WTREWDPQTSQVLAKSERNVFTQEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGNC 395
            .||..|.|....:..::         .|.||..:|:..||.|..:..|.|.|:||:|.|||.|
Human   316 ITRLQDQQVPYAVKGNQ---------WVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTG-- 369

  Fly   396 KLDEDTYEDFQKVTAAPKRSSQN-YPLLRTINEA 428
                             |..:|. |||::.:..:
Human   370 -----------------KSCNQGPYPLVQAVKRS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	125/362 (35%)
Cht2	NP_001246550.1	GH18_chitolectin_chitotriosidase	43..428	CDD:119351	134/401 (33%)
CHI3L2	NP_003991.2	GH18_chitolectin_chitotriosidase	29..387	CDD:119351	134/403 (33%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	75..76		0/7 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	102..105		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920