Protein Alignment Cht2 and CHI3L1

DIOPT Version :9

• Sequence 1: NP_001246550.1
• Gene: Cht2 / 38223
• FlyBaseID: FBgn0022702
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_001267.2
• Gene: CHI3L1 / 1116
• HGNCID: 1932
• Length: 383
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 142/408 - (34%)
• Similarity: 213/408 - (52%)
• Gaps: 74/408 - (18%)

  Fly    43 VVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKEEYGKGGYEK 107
            :|||.::|:.||...|:...:..|..||||::|:||  :|:...|.:.: |.|:..      |..
Human    24 LVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFA--NISNDHIDTWE-WNDVTL------YGM 79

  Fly   108 MTGLKRSHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQ 172
            :..||..:|:||..|::||||.||..:|.:.:|...|..|:|.|..|:|.:.||||||.|.||.:
Human    80 LNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGR 144

  Fly   173 RKGKPADRENFVLLTKELREEFDEHG------LLLTSAIGASKKVIDEAYDVRQISRYLDYLHIM 231
            |     |:::|..|.||::.||.:..      |||::|:.|.|..||.:||:.:||::||::.||
Human   145 R-----DKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIM 204

  Fly   232 CYDYHGSWDRRVGYNAPLTAPADDPLSVKFS-----IDYLLKLGAPPEKLVMGLPFYGRTFKTLA 291
            .||:||:|....|:::||....:|....:||     :.|:|:||||..|||||:|.:||:| |||
Human   205 TYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSF-TLA 268

  Fly   292 S---GFLNDVSEGVGFKGPYTREDGFLGYNEICQTLSNQTSGWTREWDPQTSQVLAKSERNVFTQ 353
            |   |....:| |.|..|.:|:|.|.|.|.|||..|...|                  ...:..|
Human   269 SSETGVGAPIS-GPGIPGRFTKEAGTLAYYEICDFLRGAT------------------VHRILGQ 314

  Fly   354 EINVVT-------YDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGN-CKLDEDTYEDFQKVTA 410
            ::...|       ||...|:.:||.:...::|||.|||::|.|||.|: |..|
Human   315 QVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQD------------ 367

  Fly   411 APKRSSQNYPLLRTINEA 428
                  ..:||...|.:|
Human   368 ------LRFPLTNAIKDA 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cht2	NP_001246550.1	Glyco_18	42..389	CDD:214753	132/366 (36%)
		GH18_chitolectin_chitotriosidase	43..428	CDD:119351	141/406 (35%)
CHI3L1	NP_001267.2	Glyco_18	23..357	CDD:214753	132/366 (36%)
		GH18_chitolectin_chitotriosidase	24..380	CDD:119351	142/408 (35%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258	204..207		1/2 (50%)
		Important for AKT1 activation and IL8 production. /evidence=ECO:0000250	324..338		3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820