DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and glpK

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_418361.1	Gene:	glpK / 948423	ECOCYCID:	EG10398	Length:	502	Species:	Escherichia coli

Alignment Length:	501	Identity:	216/501 - (43%)
Similarity:	305/501 - (60%)	Gaps:	16/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLPEQGF 100
            :|:|| |...::....|...|:..:.|...|.|:.||.|.||:|:.|:.:....|.   |.:...
E. coli    10 LDQGT-TSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEV---LAKADI 70

  Fly   101 SASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAK-VQDPNHFRSSTGLPI 164
            |:..|..:||||||||||||:..||||:|||::|:..||:...|.:... ::|  :.||:|||.|
E. coli    71 SSDQIAAIGITNQRETTIVWEKETGKPIYNAIVWQCRRTAEICEHLKRDGLED--YIRSNTGLVI 133

  Fly   165 STYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLTNGALHITDVTNASRTLLMNLETQ 229
            ..|||..|::|:.|:|...|:..|......||||:|::|.:|.|.:|:||.||||||:|.|:.|.
E. coli   134 DPYFSGTKVKWILDHVEGSRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTL 198

  Fly   230 AWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQMCVKPGQTK 294
            .||..:|:...|..||||.:...||::|:..........:.:|||.|:|||:|.||:|||.|..|
E. coli   199 DWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAK 263

  Fly   295 NTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPD 359
            |||.:|||:|.|||:|.|.|.:|||||:|  .||.....||:||||.:||.::.||:::::::.|
E. coli   264 NTYGTGCFMLMNTGEKAVKSENGLLTTIA--CGPTGEVNYALEGAVFMAGASIQWLRDEMKLIND 326

  Fly   360 SRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAALESICFQTRD 424
            :.|:|.:|..|..:..||.|||||||.||||...|||.|.|||:....|||:||.||||.:||||
E. coli   327 AYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRD 391

  Fly   425 ILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAAQADGV-- 487
            :||.|..:.|..::.|..||....||.|||.|:|.:|..|.|.::.:.||.|||..|..|.|.
E. coli   392 VLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVGFWQ 456

  Fly   488 NLCQFEPEKRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGW 533
            ||.:.: ||...|. .:...:.||   ||..||..||:||:|::.|
E. coli   457 NLDELQ-EKAVIER-EFRPGIETT---ERNYRYAGWKKAVKRAMAW 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	215/499 (43%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	215/499 (43%)
glpK	NP_418361.1	glpK	1..498	CDD:234594	216/501 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	195	1.000	Domainoid score	I120
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	410	1.000	Inparanoid score	I43
OMA	1	1.010	-	-		QHG60628
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm51314
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
	11	10.870