DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and lyxK

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_418037.1	Gene:	lyxK / 948101	ECOCYCID:	EG12284	Length:	498	Species:	Escherichia coli

Alignment Length:	496	Identity:	115/496 - (23%)
Similarity:	193/496 - (38%)	Gaps:	114/496 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQ-LPEQGFSASDIVTVGITNQRETT 117
            :|....|:.|..::||.||.|:|    ||.:.:|....|:. |...|.|...||.:||:.|.:..
E. coli    25 REAGVQRLPLCALSPQPGWAERD----MAELWQCCMAVIRALLTHSGVSGEQIVGIGISAQGKGL 85

  Fly   118 IVWDAVTGKPLYNALLWKDIRTSTTVEQ-----IVAKVQDPNHFRSSTGLPISTYFSALKIRWLR 177
            .:.|. ..|||.||:|..|.|....|.:     |..|:.........||.|:|.      :|||:
E. coli    86 FLLDK-NDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSL------LRWLK 143

  Fly   178 DNVPEVRQAIRERRCKAGTV---DSWIVWNLTNGALHITDVTNASRTLLMNLETQAWDPVLLKTF 239
            ::.|       ||..:.|.|   ..::.|.||  .:...:.:|.|.:.|.|:....:||.|....
E. coli   144 EHEP-------ERYAQIGCVMMTHDYLRWCLT--GVKGCEESNISESNLYNMSLGEYDPCLTDWL 199

  Fly   240 GIRE--EMLPTIHSCSEIFGKITSERSPLRGM--------------------------TLSGIMG 276
            ||.|  ..||.:...:||.|:||::.:.|.|:                          ||:.:||
E. coli   200 GIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGLFDVVSTALCAGIEDEFTLNAVMG 264

  Fly   277 NQQASLLGQMCVKPGQTK-------NTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIY 334
            .        ..|..|.|:       :.|..|.::  |.|:                        :
E. coli   265 T--------WAVTSGITRGLRDGEAHPYVYGRYV--NDGE------------------------F 295

  Fly   335 AIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGI-- 397
            .:..|...:...|.|...:...:......:..|.:....||::|:|...|       .|| |:
E. coli   296 IVHEASPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYG-------SNA-GLEM 352

  Fly   398 ---IIGLTQFTRKNHIVRAALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADT 459
               ..|:.....:.|:::|..|.:.|.....|..| :|...:::.|...|....:::.||:.||.
E. coli   353 TSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRM-RERFTDVHTLRVTGGPAHSDVWMQMLADV 416

  Fly   460 IGMPVFRSQLMDSTAFGAAMCAAQADGV--NLCQFEPEKRY 498
            .|:.:...|:.::..||||:.|....||  |..:.:.:.|:
E. coli   417 SGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRH 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	115/496 (23%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	115/496 (23%)
lyxK	NP_418037.1	FGGY_L-XK	4..443	CDD:212666	111/480 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	0.910