DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and KATNAL2

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001340828.1	Gene:	KATNAL2 / 83473	HGNCID:	25387	Length:	564	Species:	Homo sapiens

Alignment Length:	309	Identity:	56/309 - (18%)
Similarity:	94/309 - (30%)	Gaps:	101/309 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SPLRGMTLSGIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNT---------------GDKPVF 313
            ||.:|:.|.|               .||..|..........|.|               ||....
Human   311 SPWKGLLLYG---------------PPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 360

  Fly   314 SRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSW-----LQNKVRILPDSRDAEKYAEMVPTS 373
            .|  :|..:|....|....:..:|..:|..|.|...     |:.|..:|..       .:.:..|
Human   361 VR--VLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQ-------MDGLARS 416

  Fly   374 GDVYFVPAFTGLYAPYW-------RQNARGIIIGLTQFTRKNHIVRAALESICFQTRDILECMHQ 431
            .|:.||.|.:.|  | |       |:..:.|::.|.....:..::...|..:. ::| .|| :|.
Human   417 EDLVFVLAASNL--P-WELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVS-KSR-ALE-LHT 475

  Fly   432 ECGYEINKLHADG------KLTTNNLLMQ-----------LQADTIGMPVFRSQLMDSTAFGAAM 479
            |..|.:.....:|      ||......|:           .|:::..:|..:..::.:..|...:
Human   476 ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVL 540

  Fly   480 CAAQADGVNLCQFEPEKRYYENVHYDTFLATTTDVERKERYGKWKRAVE 528
            ...:....||.|                           ||..|:|..|
Human   541 THTKPSAKNLAQ---------------------------RYSDWQREFE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	56/309 (18%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	56/309 (18%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
KATNAL2	NP_001340828.1	SpoVK	<264..559	CDD:223540	54/304 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900