DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and ATAD2B

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	398	Identity:	79/398 - (19%)
Similarity:	127/398 - (31%)	Gaps:	117/398 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FSIYTTP-------DFKEIAAHRVELS-VITPQDGWYEQDPLEMMASINKCAEEAIKQLPEQGFS 101
            |:|::.|       |:.|:....::|| |||..|........:.:..|:.....|::..|::. .
Human   994 FNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKD-P 1057

  Fly   102 ASDIVTVGITNQRETTIVWDAVTGKPLYNALL--WKDIR----TSTTVEQIVAKVQDPNHFRSST 160
            ...|:.......::|.....|....|.:|.|.  .|:.|    .|.|.|||     :|:    ||
Human  1058 GDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTSEQI-----NPH----ST 1113

  Fly   161 GLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLTN------------------ 207
            |              .|.....|.:|.|.:  :...:|.|  .|..|
Human  1114 G--------------ARKTETRVEEAFRHK--QRNPMDVW--HNSANKCAFRVRRKSRRRSQWGK 1160

  Fly   208 GALHITDVTNASR----TLLMNLETQAWDPVLLKT--FGIREEMLPTIHSCSEIFGKITSERSPL 266
            |.:....|.|..:    |...:.|....|..||:.  |.:..:       |.|..|:.|.:.|..
Human  1161 GIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTD-------CHEENGEETGDLSMT 1218

  Fly   267 ------------RGMTLSGIMGNQQ-----------ASLL--GQMCVKPGQT--KNTYRSGCFLL 304
                        :|..|:...|.::           .|||  ....:.|.||  |.|:..|   .
Human  1219 NDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKETFLKG---N 1280

  Fly   305 CNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSW--LQNKVRILPDSRDAEKYA 367
            |..|:....|..|:            |.:....|.:.|.....|.  ..::.:||.:.:..||..
Human  1281 CLNGEASTDSFEGI------------PVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPE 1333

  Fly   368 EMVPTSGD 375
            ......||
Human  1334 TSTENHGD 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	79/398 (20%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	79/398 (20%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640
		AAA	452..586	CDD:278434
		COG5076	866..>1100	CDD:227408	22/106 (21%)
		Bromo_AAA	974..1085	CDD:99957	18/91 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900