DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and kat-60L1

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001163523.1	Gene:	kat-60L1 / 40715	FlyBaseID:	FBgn0037375	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	97/534 - (18%)
Similarity:	175/534 - (32%)	Gaps:	104/534 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFRSKELRKQSLIQHTGL---------VGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQ- 69
            |.|:..|:|.|...|:..         :|....|...||.|:....  |:....:|..:.:.||
  Fly   142 PSRNASLKKSSEGGHSSTAERHRPVNNLGSNAPGGLGIGGSVPLRS--KQRLPTQVSAAEVAPQP 204

  Fly    70 ----------------DGWY----EQDPLEM---MASINKCAEEAIKQLPEQGFSASDIVTVGIT 111
                            :.|.    .:|| |:   :.|||..|..:.......| ||.::...|..
  Fly   205 RASQTAQMPFPSQQQDNRWVSSLRRRDP-ELQPTLPSINSNANSSSLSQSHHG-SAGNVGLAGAG 267

  Fly   112 NQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHFRSSTGLPISTYFSALKIRWL 176
            .......:.....|:|...:.:...:|.|.:||::.|:       :.||...::.....:|...|
  Fly   268 APTPAASMGTMRLGRPARASAMTAALRKSRSVERLRAR-------KLSTNTQLNLKHKPVKKNSL 325

  Fly   177 RDN-----------------VPEVRQAIRERRCKAGTVDSWIVWNLTNGALHITDVTNASRTLLM 224
            .:|                 ...:..:....:|...|....  ::.....:|:.|  ...:.:|.
  Fly   326 DENSNSDDQDATTSLEDNSHAQSLATSHNTPKCSPKTKAKH--FSPLGYEVHLVD--TLEKDILQ 386

  Fly   225 NLETQAWDPVL----LKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQ 285
            ......|..|.    .||......:||.|  ..|.|..|   |.|.||:.:.|..|..:..|...
  Fly   387 RHPCIKWTDVAGLNEAKTILQEAVVLPVI--MPEFFKGI---RRPWRGVLMVGPPGTGKTMLAKA 446

  Fly   286 MCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAG-----H 345
            :..:.|.|.....|........|:.....|  ||..:|....|....|..|:...:..|     .
  Fly   447 VATECGTTFFNVSSSTLTSKYRGESEKLVR--LLFEMARFYAPSTIFIDEIDALCASRGSDSEHE 509

  Fly   346 ALSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTG----LYAPYWRQNARGIIIGLTQFTR 406
            |....:.::.|..|..:|....|      .|..|.|.|.    :...:.|:..:.|.|.|.....
  Fly   510 ASRRFKAELLIQMDGLNASMQEE------KVIMVLAATNHPWDIDEAFRRRFEKRIYIPLPNEGT 568

  Fly   407 KNHIVRAALESIC----FQTRDILECMHQECGYEINKLHADGKL---------TTNNLLMQLQAD 458
            ::.:::..|:.:|    ..|..|.:.:....|.:|:.:..|..:         .|.:.:.|::.:
  Fly   569 RSALLKLCLKDVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRLISGRTPDQIKQIRRE 633

  Fly   459 TIGMPVFRSQLMDS 472
            .:..|:......|:
  Fly   634 EVDQPITLQDFQDA 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	91/518 (18%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	91/518 (18%)
kat-60L1	NP_001163523.1	AAA	426..565	CDD:214640	31/146 (21%)
		AAA	430..563	CDD:278434	27/140 (19%)
		Vps4_C	<638..671	CDD:286426	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900