DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and fggy

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_998446.2	Gene:	fggy / 406567	ZFINID:	ZDB-GENE-040426-2461	Length:	545	Species:	Danio rerio

Alignment Length:	548	Identity:	116/548 - (21%)
Similarity:	206/548 - (37%)	Gaps:	139/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLPE 97
            ||| |.|:.::..:: .:||.:........::|..|....|||...|:.   :||. :.:|::.|
Zfish     7 VGV-DVGSASVRAAL-VSPDGQLRRTAEEPIAVHEPCVDHYEQSSTEIW---SKCC-QTVKRVTE 65

  Fly    98 QGFSASDIVTVGITNQRETTIVWDAVTGKPL---------YNALLWKDIRTSTTVEQIVA----- 148
             |..|:.:..:|........::....  :||         .|.::|.|.|.:....:|.|
Zfish    66 -GVDAACVRGIGFDGTCSLVVLDQQF--RPLAVNLAGVCDRNVVMWMDHRAAAQASRITACRHTL 127

  Fly   149 ----------KVQDPNHFRSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVW 203
                      ::|.|                  |:.||::|:|:   :...|......:..::.|
Zfish   128 LQRVGGVMSPEIQPP------------------KLLWLKENLPD---SCWTRAAHFFDLPDFLSW 171

  Fly   204 NLTNGALHITDVTNASRTLLMNL------ETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSE 262
            ..| |:|        ||:|...:      .::.||.......|: |:::      .:.:.:|.|:
Zfish   172 KAT-GSL--------SRSLCTLVCKWTYSASEGWDDTFWSAIGL-EDLI------EDSYARIGSQ 220

  Fly   263 -----RSPLRGMTLSGI--MGNQQASLLGQMCVKP--------GQTKNTYRSGC---------FL 303
                 .:..||:|.:..  :|..:.:.:|...:..        |...:.....|         .|
Zfish   221 VCCPGAAVGRGLTAAAAADLGLNEGTAVGASLIDAHAGGIGVLGADVSGLHLPCEHQPLTARMAL 285

  Fly   304 LCNTGD-KPVFSRHGLLTTVAYKLGP----QAPTIYAIEGAVS---------VAGHAL------- 347
            :|.|.. ....||..||....:  ||    ..|.::..||..|         |.|||.
Zfish   286 ICGTSSCHMAVSREPLLVPGVW--GPYLSAMLPGLWLNEGGQSATGKLLDHVVKGHAAFRQLEEQ 348

  Fly   348 -------SWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFT 405
                   .:.|..:.:...|.|| .:.|.:.|  .::..|.|.|..:|...|.|||.::||:...
Zfish   349 AEHSGRHIYTQLNLHLQQMSTDA-THLEQLTT--HLHIWPDFHGNRSPLADQTARGTVVGLSLSQ 410

  Fly   406 RKNHIV---RAALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRS 467
            ..:.:.   .|.|:::...:|.|:..| .|.|::|..|...|.|:.|.|.:|..|:|.|:||...
Zfish   411 TLDDLALLYLATLQALALGSRHIIAAM-TEAGHDITTLFLCGGLSKNTLFVQTHANTTGLPVVLP 474

  Fly   468 QLMDSTAFGAAMCAAQADGVNLCQFEPE 495
            ...::...|||:..|.|.  :.|...||
Zfish   475 AEREAVLLGAAVIGACAS--SDCTSIPE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	116/548 (21%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	116/548 (21%)
fggy	NP_998446.2	FGGY_YpCarbK_like	4..539	CDD:212663	116/548 (21%)
fggy	NP_998446.2	5C_CHO_kinase	5..538	CDD:273552	116/548 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910