DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and CG11594

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	113/576 - (19%)
Similarity:	190/576 - (32%)	Gaps:	173/576 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PQDGWYEQDPLEMMASINKCAEEAIKQLPEQ-----GFSAS-DIVTVGITNQRETTIVWDAVTGK 126
            |:.|:|.|....:..||.:..::.|..:.:.     ||.|: .:|.:|......|.    :.:|:
  Fly    41 PEPGYYNQSSDNIWQSICQVVKKVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTV----SKSGE 101

  Fly   127 PLYNALLWKDIRTSTTVEQIVAKVQDPNHFRSS----TGLPISTYFSALKIRWLRDNVPEVRQAI 187
            ...|.:||.|.|.....::|       |.|:.|    .|..:|......|:.||:.|:.:.
  Fly   102 AEQNIILWMDHRAEQETQEI-------NAFKHSLLKYVGGQVSLEMEVPKLLWLKRNLSQT---- 155

  Fly   188 RERRCKAGTVDSWIVWNL------------TNGALHIT-----DVTNASRTLLMNLETQAWDPVL 235
                  .|.:  |.|::|            |.....:.     |..|.|           |:...
  Fly   156 ------FGNI--WRVFDLPDFLTWRATGVDTRSLCSVVCKWNYDAANGS-----------WNKEF 201

  Fly   236 LKTFGIREEMLPTIHSCSEIFGKITSERSPL-----RGMTLSGIMGNQQASLLGQMCVKPGQTKN 295
            ||...:.|       .....|.|:.|:..|.     :|:|         |...|::.:..|...:
  Fly   202 LKQADLEE-------LTQNNFEKLGSDVQPPGRTVGKGLT---------AKAAGELGLSAGTVVS 250

  Fly   296 TY----------RSGCFLLCNTGDKPVFSRHGLLT-------TVAYKL-------GPQ----APT 332
            |.          ..||....:.|...|..:..|:.       ::..|.       ||.    .|.
  Fly   251 TSLIDAHAGALGMFGCRSKESKGADDVQGKMALIAGTSTCHMSITRKACFAQGVWGPYQDAIIPG 315

  Fly   333 IYAIEGAVSVAGHALSWL---------------------QNKVRILPDSRDAEKYAEMVPTSGDV 376
            .:..||..|:|||.|..:                     |:..::||:...|...:::...:.||
  Fly   316 YFLNEGGQSIAGHLLDHVLKSHESYAELKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCLTQDV 380

  Fly   377 YFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVR----AALESICFQTRDILECMHQECGYEI 437
            :..|...|..:|......||:|.|| ..||....:.    |.::::.:.||.|:|.::|......
  Fly   381 HVWPDLHGNRSPIADPTLRGVITGL-DMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPF 444

  Fly   438 NKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAAQADGVNLCQFEPEKRYYENV 502
            ..|...|.|..|.|.:|..||...:|.......:....|||...|.|.|
  Fly   445 QTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALGAAASG---------------- 493

  Fly   503 HYDTFLATTTDVERKERYGKWKRAVERSLG----WVIKQKKTREYTEENYRMLSSL 554
            |:|:.                 .:..:|:|    .|....:|.|:....|::...|
  Fly   494 HFDSL-----------------ESASKSMGGTGQLVKPNAETLEFHNRKYKVFLQL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	108/553 (20%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	108/553 (20%)
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	113/576 (20%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	113/576 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740