DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and Atad2b

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001349278.1	Gene:	Atad2b / 320817	MGIID:	2444798	Length:	1457	Species:	Mus musculus

Alignment Length:	377	Identity:	74/377 - (19%)
Similarity:	124/377 - (32%)	Gaps:	123/377 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FSIYTTP-------DFKEIAAHRVELS-VITPQDGWYEQDPLEMMASINKCAEEAIKQLPEQGFS 101
            |:|::.|       |:.|:....::|| |||..|........:.:..|:.....|::..|::. .
Mouse   979 FNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLQDIDLICSNALEYNPDKD-P 1042

  Fly   102 ASDIVTVGITNQRETTIVWDAVTGKPLYNALL--WKDIR----TSTTVEQIV----------AKV 150
            ...|:.......::|.....|....|.:|.|.  .|:.|    .|.|.|||.          .:|
Mouse  1043 GDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQITPHGAGARKTETRV 1107

  Fly   151 QDPNHFRSSTGLPISTYFS-----ALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWN------ 204
            ::.  ||.....|:..:.:     |.::|         |::.|..:...|.:....|.|
Mouse  1108 EEA--FRHKQRNPMDAWHNSANKCAFRVR---------RKSRRRSQWGKGIIKKRKVNNLKKDEE 1161

  Fly   205 ---------------LTNGALHI-TDV--TNASRT--LLMNLETQAWDPV-------LLKTFGIR 242
                           |.||...: ||.  .|...|  |.|..:..:.|.:       |....|.:
Mouse  1162 DTKFTDYDHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNSGAGTK 1226

  Fly   243 EEMLPT----------IHSCSEIFGKITSERSP-LRGMTLSG----------------------- 273
            |....|          :||.|.:..:.||::.| |:|..|:|
Mouse  1227 ENFASTEEESSNESLLVHSSSSLNPEQTSKKEPFLKGTCLNGEASTDSSEGIPVLECQNGRVLEV 1291

  Fly   274 ---------IMGNQQASLLGQMCVKPGQTKNTYRSGC-----FLLCNTGDKP 311
                     ....|:.:|..|:..|| :|.|..|...     .|.|::.:||
Mouse  1292 VPLPDGGEKSSSEQKIALEEQLKDKP-ETWNENRGDAAEKLEVLECSSSEKP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	74/377 (20%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	74/377 (20%)
Atad2b	NP_001349278.1	TIP49	<396..>668	CDD:332389
Atad2b	NP_001349278.1	Bromo_AAA	959..1070	CDD:99957	18/91 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900