DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk2 and Gykl1

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_599168.1	Gene:	Gykl1 / 291468	RGDID:	1305596	Length:	549	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	253/541 - (46%)
Similarity:	360/541 - (66%)	Gaps:	12/541 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.:|:||.:..|.::.....:.:..|:||::...|::||.||||..::.|:.:|.|:..::|.
  Rat    12 LVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPREGWVEQDPKVILQSVYECIEKTCEKLG 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHF-RSST 160
            :|....|:|..:|:|||||||||||..||:|||||::|.|:||.:|||.:...:...|:| :..|
  Rat    77 QQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLNKSISASNNFIKIKT 141

  Fly   161 GLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRTL 222
            ||||||||||:|:.||.:||..|::||.:.|...||||||::|.:|   ||.:|.|||:|||||:
  Rat   142 GLPISTYFSAVKLHWLIENVKNVQKAIEDGRAFFGTVDSWLIWCMTGGINGGVHCTDVSNASRTM 206

  Fly   223 LMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQMC 287
            |.|:.:..||..|.:.|||...:||.|.|.|||:|.:.|  ..|.|:.:||.:|:|.|:|:||:|
  Rat   207 LFNIHSLQWDEELCEFFGIPMTILPRIRSSSEIYGLMKS--GVLEGVPISGCLGDQSAALVGQLC 269

  Fly   288 VKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQN 352
            ::.||.|:||.:|||||||||.|.|.|.||||||||||:|.:.|..||:||:|::||..:|||:|
  Rat   270 LQDGQAKSTYGTGCFLLCNTGQKCVNSDHGLLTTVAYKMGREEPVYYALEGSVAIAGAVVSWLKN 334

  Fly   353 KVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAALES 417
            .::|:..|.|.||.||...||...||||||:|||||||..:|||||.||||||.|.||..||||:
  Rat   335 NLQIIKSSSDIEKLAEKAGTSYGCYFVPAFSGLYAPYWDPSARGIICGLTQFTNKFHIAFAALEA 399

  Fly   418 ICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAA 482
            :|||||:||:.|:.:||..:..|..||.:|.|.:|||||||.:.:||.:..:.::||.||||.|.
  Rat   400 VCFQTREILDAMNSDCGIPLTHLQVDGGMTANKILMQLQADILCIPVMKPFMPETTALGAAMAAG 464

  Fly   483 QADGVNLCQFEPEKRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKKTREYTEEN 547
            .|:|:.:...:|:.  ...|..:.|.......|.:.||..|||||.:|:|||:    |:.....:
  Rat   465 AAEGIRVWSLDPKD--LTGVQMEKFEPQINVEESEGRYSTWKRAVMKSMGWVL----TQSPDGHD 523

  Fly   548 YRMLSSLPASIFLISSFAMLV 568
            ..:..||....:::||..:|:
  Rat   524 PSIFRSLTLGFYIVSSMVLLI 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	244/504 (48%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	244/504 (48%)
Gykl1	NP_599168.1	glycerol_kin	11..513	CDD:273549	244/504 (48%)
Gykl1	NP_599168.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	244/504 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337236
Domainoid	1	1.000	40	1.000	Domainoid score	I12211
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.720