Protein Alignment Gk2 and ATAD2

DIOPT Version :9

• Sequence 1: NP_001286904.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_054828.2
• Gene: ATAD2 / 29028
• HGNCID: 30123
• Length: 1390
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 105/569 - (18%)
• Similarity: 165/569 - (28%)
• Gaps: 216/569 - (37%)

  Fly    19 KELRKQSLIQHTGLVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMAS 83
            |::|:|.:.:...| ||.:| |:....::||....|:|  .|.:......|:|           |
Human   192 KKMRRQRMRELEDL-GVFNE-TEESNLNMYTRGKQKDI--QRTDEETTDNQEG-----------S 241

  Fly    84 INKCAEEAIKQLPEQGFSASDIVTVG---------------------------ITNQRETTIVWD 121
            :....|...::..:.|....|.....                           ...||:.|:.:.
Human   242 VESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQ 306

  Fly   122 AVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHFRSSTGLPISTYFSALKIRWLRDNVPEVRQA 186
            |...||.:.                    :.||.|.|....|..               |..|.:
Human   307 APLEKPRHQ--------------------RKPNIFYSGPASPAR---------------PRYRLS 336

  Fly   187 I---RERRCKAGTVDSWIVWNLTNGALHITDVTNAS---------------------RTLLMNLE 227
            .   |...||.        .|....|:|.:|.|::|                     |.|.:|..
Human   337 SAGPRSPYCKR--------MNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFR 393

  Fly   228 TQAW-----------------DPVLLKTFGIR--------------EEML--PTIHSCSEIFGKI 259
            ....                 ||:.|.: .:|              :||:  |.::  .|:|.|.
Human   394 KDELKGIYKDRMKIGASLADVDPMQLDS-SVRFDSVGGLSNHIAALKEMVVFPLLY--PEVFEKF 455

  Fly   260 TSERSPLRGMTLSGIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNTGDKPV--FSRHG----- 317
            ..:  |.||....|               .||..|..........|:.|||.|  |.|.|
Human   456 KIQ--PPRGCLFYG---------------PPGTGKTLVARALANECSQGDKRVAFFMRKGADCLS 503

  Fly   318 -----------LLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVP 371
                       ||...||::.|.......|:|...|.               .||..:.::.:|.
Human   504 KWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR---------------SSRQDQIHSSIVS 553

  Fly   372 TSGDVYFVPAFTGLYAPYWRQNARG--IIIGLTQFTRKNHIVRAALESICFQTRDILECMHQECG 434
            |     .:....||       ::||  ::||.|  .|.:.|..|......|....:.....:|..
Human   554 T-----LLALMDGL-------DSRGEIVVIGAT--NRLDSIDPALRRPGRFDREFLFSLPDKEAR 604

  Fly   435 YEINKLHAD--GKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCA 481
            .||.|:|..  .....:..|.:|..:.:|   :....:.|....||:||
Human   605 KEILKIHTRDWNPKPLDTFLEELAENCVG---YCGADIKSICAEAALCA 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	102/557 (18%)
		FGGY_GK1-3_metazoa	31..533	CDD:212664	102/557 (18%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..380		33/219 (15%)
		AAA	459..600	CDD:214640	38/184 (21%)
		AAA	464..598	CDD:278434	35/177 (20%)
		COG5076	<915..1153	CDD:227408
		Bromo_AAA	987..1097	CDD:99957
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1242

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900