DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and Shpk

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001028854.1	Gene:	Shpk / 287479	RGDID:	1308004	Length:	472	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	108/523 - (20%)
Similarity:	191/523 - (36%)	Gaps:	135/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IDEGTKTI-------------GFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKC 87
            ||.||.::             ||.:..:  ....|....|.:...||.  .|||...::.::|:|
  Rat    10 IDLGTTSVKAALLEAAPGHPSGFVVLAS--CARAAGAETESAAAGPQG--REQDVTRIIQALNEC 70

  Fly    88 AEEAI--KQLPEQGFSASDIVTVGITNQRETTIVWDAVTG--------KPLY------NALLWKD 136
            . :|:  :||...|       .:|::.|....:.|....|        .|::      :.:.|:|
  Rat    71 L-DALPPRQLQRVG-------AIGVSGQMHGILFWKTGQGCEWTERGSAPVFEPRAVSHLVTWQD 127

  Fly   137 IRTSTTVEQIVAKVQDP-NHFRSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSW 200
            .|.::   ..:|.:..| :|...:||...:|.|      ||..|.||..::..    .|||:..:
  Rat   128 NRCNS---GFLASLPKPASHLSVATGFGCATIF------WLLKNSPEFLKSYD----VAGTIQDY 179

  Fly   201 IVWNLTNGALHITDVTNASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSP 265
            :|..|......:....||:.....|.::|:|:..:|:..|....:||.|.....:.|:.:.....
  Rat   180 VVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNSDILQMAGFPTHLLPDIAEPGSLAGRTSHTWFE 244

  Fly   266 LRGMTLSGI-MGNQQASL---LGQ-------------------MCVKPGQTKNTYRSGCFLLCNT 307
            :...|..|: :|:.|||:   :||                   :..:|.||.:......|.
  Rat   245 IPAGTEVGVALGDLQASVYSCMGQRTDAVLNISTSVQLAASMPVGFQPPQTPDPAAPVAFF---- 305

  Fly   308 GDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHAL-SWLQNKVRILPDSRDAEKYAEMVP 371
               |.|.|..|....:...|....|..          |.| .|:.:   :..:..::..|:.|:.
  Rat   306 ---PYFDRTYLGVAASLNGGNVLATFV----------HMLVQWMTD---LGLEVEESTVYSRMIQ 354

  Fly   372 TSGD-----VYFVPAFTG------LYAPYWRQNARGIIIGLTQFTRKNHIVRAALESICFQTRDI 425
            .:..     :...|...|      ..|...|.::..:.:|        |:.||    :|   |.|
  Rat   355 AAAQQKDTHLTITPTVLGERHLPDQLASVTRISSSDLSLG--------HVTRA----LC---RGI 404

  Fly   426 LECMH--------QECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAA 482
            ::.:|        ||.|.| ..:.:...|:.|.:|.|........||...|.:|: |||||:...
  Rat   405 VQNLHSMLPFQQLQEWGVE-RVVGSGSALSRNEVLKQEVQRAFPFPVCFGQDVDA-AFGAALVML 467

  Fly   483 QAD 485
            :.|
  Rat   468 RRD 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	108/523 (21%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	108/523 (21%)
Shpk	NP_001028854.1	FGGY_SHK_like	5..466	CDD:212661	107/517 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810