DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk2 and GK2

DIOPT Version :9

Sequence 1:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_149991.2	Gene:	GK2 / 2712	HGNCID:	4291	Length:	553	Species:	Homo sapiens

Alignment Length:	555	Identity:	261/555 - (47%)
Similarity:	374/555 - (67%)	Gaps:	26/555 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.:.:||.:..|.::.:...:.::.|:|||:...|::||.||||.|::.|:.:|.....::|.
Human    12 LVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEKLD 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHF-RSST 160
            |.....|:|..||::||||||::||.:||:|||||::|.|:||.||||.:..|:...::| :|.|
Human    77 ELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKT 141

  Fly   161 GLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLT---NGALHITDVTNASRTL 222
            |||:||||||:|:||:.|||..|::|:.|.|...||:|||::|:||   ||.:|.|||||||||:
Human   142 GLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTM 206

  Fly   223 LMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQMC 287
            |.|:.:..||..|...|.|..::||.:.|.|||:|.|  :...|.|:.:||.:|:|.|:|:||||
Human   207 LFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLI--KTGALEGVPISGCLGDQCAALVGQMC 269

  Fly   288 VKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQN 352
            .:.||.||||.:|||||||||.|.|||.||||||||||||.:.|..||:||:|::||..:.||::
Human   270 FQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRD 334

  Fly   353 KVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAALES 417
            .:.|:..|.|.|:.|:.|.||...||||||:|||||||..:||||:.||||||.|.||..||||:
Human   335 NLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEA 399

  Fly   418 ICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAA 482
            :|||||:|||.|:::||..:..|..||.:|.|.:|||||||.:.:||.:..:.::||.||||.|.
Human   400 VCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAG 464

  Fly   483 QADGVNLCQFEPE-------KRYYENVHYDTFLATTTDVERKERYGKWKRAVERSLGWVIKQKKT 540
            .|:||::...||:       :|:...:.     ||.:::    ||..||:||.:|:|||..|  :
Human   465 AAEGVSVWSLEPQALSVLRMERFEPQIQ-----ATESEI----RYATWKKAVMKSMGWVTSQ--S 518

  Fly   541 REYTEENYRMLSSLPASIFLISSFAMLVHSLAASG 575
            .|..:.:  :.||||...|::||..||:.:...||
Human   519 PEGGDPS--IFSSLPLGFFIVSSMVMLIGARYISG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	245/511 (48%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	245/511 (48%)
GK2	NP_149991.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	245/511 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143491
Domainoid	1	1.000	46	1.000	Domainoid score	I12126
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720