Protein Alignment Gk2 and GK

DIOPT Version :9

• Sequence 1: NP_001286904.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: XP_011543793.1
• Gene: GK / 2710
• HGNCID: 4289
• Length: 587
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 262/580 - (45%)
• Similarity: 373/580 - (64%)
• Gaps: 42/580 - (7%)

  Fly    32 LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLP 96
            |||.:|:||.:..|.::.:...:.::.|:||:....|::||.||||.|::.|:.:|.|:..::|.
Human    12 LVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLG 76

  Fly    97 EQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNAL----------------------------L 133
            :.....|:|..:|::||||||:|||.:||:|||||:                            :
Human    77 QLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSGSSVPAPGTSSV 141

  Fly   134 WKDIRTSTTVEQIVAKVQDPNHF-RSSTGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTV 197
            |.|:||.:|||.:..::...|:| :|.||||:||||||:|:|||.|||.:|::|:.|:|...||:
Human   142 WLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTI 206

  Fly   198 DSWIVWNLT---NGALHITDVTNASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKI 259
            |||::|:||   ||.:|.|||||||||:|.|:.:..||..|.:.|||..|:||.:.|.|||:|.:
Human   207 DSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLM 271

  Fly   260 TSERS----PLRGMTLSGIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLT 320
            ....|    .|.|:.:||.:|:|.|:|:||||.:.||.||||.:|||||||||.|.|||.|||||
Human   272 KISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLT 336

  Fly   321 TVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGL 385
            |||||||...|..||:||:|::||..:.||::.:.|:..|.:.||.|:.|.||...||||||:||
Human   337 TVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGL 401

  Fly   386 YAPYWRQNARGIIIGLTQFTRKNHIVRAALESICFQTRDILECMHQECGYEINKLHADGKLTTNN 450
            |||||..:|||||.||||||.|.||..||||::|||||:||:.|:::||..::.|..||.:|:|.
Human   402 YAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNK 466

  Fly   451 LLMQLQADTIGMPVFRSQLMDSTAFGAAMCAAQADGVNLCQFEPEKRYYENVHYDTFLATTTDVE 515
            :|||||||.:.:||.:..:.::||.||||.|..|:||.:...|||.  ...|..:.|.......|
Human   467 ILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPED--LSAVTMERFEPQINAEE 529

  Fly   516 RKERYGKWKRAVERSLGWVIKQKKTREYTEENYRMLSSLPASIFLISSFAMLVHSLAASG 575
            .:.||..||:||.:|:|||    .|:.....:..:..|||...|::||..||:.:...||
Human   530 SEIRYSTWKKAVMKSMGWV----TTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISG 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	248/536 (46%)
		FGGY_GK1-3_metazoa	31..533	CDD:212664	248/536 (46%)
GK	XP_011543793.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	248/536 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143493
Domainoid	1	1.000	46	1.000	Domainoid score	I12126
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21848
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1003
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.670