Protein Alignment Gk2 and GK5

DIOPT Version :10

• Sequence 1: NP_647655.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001034636.1
• Gene: GK5 / 256356
• HGNCID: 28635
• Length: 529
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 160/555 - (28%)
• Similarity: 263/555 - (47%)
• Gaps: 72/555 - (12%)

  Fly    17 RSKELRKQSLIQHTGLVGVIDEGTKTIGFSIYTTPDFKEIAAHRV------ELSVITPQDGWYEQ 75
            |::|.|      :.|.|..:|.|:..|...:|.       .|.||      ::..:.||.||.|.
Human    11 RAQEPR------YPGFVLGLDVGSSVIRCHVYD-------RAARVCGSSVQKVENLYPQIGWVEI 62

  Fly    76 DPLEMMASINKCAEEAIKQLPEQGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTS 140
            ||..:........:||:|   ..|...:.||.:||:.||.|.|.|:..||...:|.:.|:|:|..
Human    63 DPDVLWIQFVAVIKEAVK---AAGIQMNQIVGLGISTQRATFITWNKKTGNHFHNFISWQDLRAV 124

  Fly   141 TTVE----QIVAKVQDPN----HF--RS-----STGLPISTYFSALKIRWLRDNVPEVRQAIRER 190
            ..|:    .::.|:...:    ||  ||     ::....:|..::|::.|:..|:.||::|:.|.
Human   125 ELVKSWNNSLLMKIFHSSCRVLHFFTRSKRLFTASLFTFTTQQTSLRLVWILQNLTEVQKAVEEE 189

  Fly   191 RCKAGTVDSWIVWNLTNGALHITDVTNASRTLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEI 255
            .|..||:|:|:::.||.|:::.||.:|||.|.|.:.....|..::.....|...:||.:...|..
Human   190 NCCFGTIDTWLLYKLTKGSVYATDFSNASTTGLFDPYKMCWSGMITSLISIPLSLLPPVRDTSHN 254

  Fly   256 FGKITSERSPLRGMTLS--GIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGL 318
            ||.:..|   :.|:.:.  .::.:||:::.|:.|.:.|..|.|..:|.||..|||:....:..|.
Human   255 FGSVDEE---IFGVPIPIVALVADQQSAMFGECCFQTGDVKLTMGTGTFLDINTGNSLQQTTGGF 316

  Fly   319 LTTVAYKLGPQAPTIYAIEGAVSVAGHALSWLQNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFT 383
            ...:.:|:|.:  .:...|......|.|:.|.| ::.:..|:.:.||.|:.:..|..|.|||:|:
Human   317 YPLIGWKIGQE--VVCLAESNAGDTGTAIKWAQ-QLDLFTDAAETEKMAKSLEDSEGVCFVPSFS 378

  Fly   384 GLYAPYWRQNARGIIIGLTQFTRKNHIVRAALESICFQTRDILECMHQECGYEINKLHADGKLTT 448
            ||.||.....|....:||...|.|.|:|||.||||.|:.:.:.|.|.:|....:.|:.|||.:..
Human   379 GLQAPLNDPWACASFMGLKPSTSKYHLVRAILESIAFRNKQLYEMMKKEIHIPVRKIRADGGVCK 443

  Fly   449 NNLLMQLQADTIGMPVFRSQLMDSTAFGAAMCAAQADGV--------NLCQ----FEPEKRYYEN 501
            |..:||:.:|.|...:.|...:|.:..|||..|..|.|.        .|.|    |:|:|:..|
Human   444 NGFVMQMTSDLINENIDRPADIDMSCLGAASLAGLAVGFWTDKEELKKLRQSEVVFKPQKKCQE- 507

  Fly   502 VHYDTFLATTTDVERKERYGKWKRAVERSLGWVIK 536
              |:..|.            .|.:||:||:.|..|
Human   508 --YEMSLE------------NWAKAVKRSMNWYNK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gk2	NP_647655.1	glycerol_kin	31..533	CDD:273549	155/536 (29%)
GK5	NP_001034636.1	ASKHA_NBD_FGGY_GK5-like	20..520	CDD:466803	151/530 (28%)